Synthetic Progestin Levonorgestrel Research Articles

Norplant: Reversible Implant Contraception

Through 2 years of comparative clinical trials Norplant a subdermal contraceptive implant system containing the synthetic progestin levonorgestrel has had a net cumulative pregnancy rate of 0.4 per 100. This rate was significantly below rates for another implant contraceptive and for the TCu 200 IUD. The major side effect of the method has been irregular bleeding. The experience of the pilot clinical study through 3 years and the release rates of levonorgestrel from the implanted capsules indicate that a single administration of Norplant will provide effective protection against pregnancy for at least 5 years. (Authors)