AbstractBackgroundThe multimer detection system‐oligomeric amyloid‐β (MDS‐OAβ) measures OAβ level in plasma after spiking of synthetic amyloid beta into the plasma and has shown in clinical studies that Alzheimer’s disease patients have higher tendency level of amyloid‐β oligomerization. Since Alzheimer’s disease is a neurodegenerative disease, this study was to investigate whether young to old age groups in health check‐up subjects shows different level of OAβ in plasma.MethodTotal of 6,150 subjects were studied; 678 subjects in their between twenties and forties (≤40s, the average age was 42.9±5.4), 1,276 in their fifties (50s, 55.0±2.9), 1,945 in their sixties (60s, 64.3±2.9), 1,520 in their seventies (70s, 74.3±2.9) and 731 in more than 80 years old (≥80s, 83.6±3.4). The multimer detection system assay kit (AlzOn, PeopleBio, Inc., South Korea) was used to quantify the levels of OAβ in the plasma. ANOVA test and t‐test were used to compare results for statistics.ResultThe plasma tendency levels of OAβ in the ≤40s, 50s, 60s, 70s and ≥80s were 0.46±0.31ng/mL, 0.51±0.35ng/mL, 0.52±0.24ng/mL, 0.56±0.30ng/mL and 0.57±0.24ng/mL, respectively. There was no difference between the 50s and 60s, and 70s and ≥80s, but the differences among the others were statistically significant (p<0.001). In particular, plasma OAβ tendency levels gradually increased with age. The women’s average level (n, mean±SD; 3,665, 0.53±0.30 ng/mL) was higher than the men’s (2,485, 0.52±0.28)ng/mL, it was statistically significant (p<0.001). The positive rates of ≤40s, 50s, 60s, 70s and ≥80s were 8.0%, 10.7%, 12.0%, 15.3% and 18.1%, respectively, based on the level (>0.78ng/mL) of the manufacturer.ConclusionAs age increased, the plasma OAβ tendency levels and positive rates were increased. Therefore, as age increases, the possibility of Alzheimer’s disease increases.