This study presents novel comprehensive comparisons of alternative refinery configurations for sustainable aviation fuels (SAF) from bio-ethanol or Fischer-Tropsch bio-syncrude through techno-economic evaluations. Simulations were conducted in Aspen Plus, followed by evaluating the minimum aviation-fuel selling price (MINAFSP) at specific feedstock price, and the maximum tolerable prices of ethanol or syncrude at incentivised SAF prices. FT-syncrude refining scenarios considered (i) a basic refinery, (ii) incorporating synthetic aromatics, (iii) incorporating synthetic alkanes, and (iv) combined technology. Scenarios for refining bio-ethanol to higher alkanes considered (i) the base Heveling Process, (ii) Hybrid Process, (iii) the patented PNNL process, and (iv) the pre-upgrading of ethanol to butanol. Thus, the basic refining of syncrude had the lowest refining efficiency of 76%, a capital cost (CAPEX) of 117 million US$, and a MINAFSP of 0.52 US$/l, while the synthetic aromatics was most efficient at 91%, and costing 0.41 US$/l. For bio-ethanol refining, the Hybrid Process was most efficient at 80% and resulted in a MINAFSP of 0.89 US$/l. When considering an aviation fuel ecotax of 0.33 US$/l for the most viable scenarios, the syncrude was tolerated at 145 US$/bbl, while ethanol was tolerated at 371 US$/m3. Thus, simpler configurations generally had lower efficiency with lower economic potential.