Event Abstract Back to Event Biomedical coatings prepared by magnetron sputtering Sandra Rodil1, Phaedra Silva-Bermudez2, Argelia Almaguer-Flores3 and Rene Olivares-Navarrete4 1 Universidad Nacional Autónoma de México, Instituto de Investigaciones en Materiales, Mexico 2 Instituto Nacional de Rehabilitación, Terapia Celular y Medicina Regenerativa, Mexico 3 Universidad Nacional Autónoma de México, Facultad de Odontología, Mexico 4 Virginia Commonwealth University, 2Department of Biomedical Engineering, United States Introduction: Nowadays, it is generally accepted that surfaces are critically important to determine the degree of tissue interaction between an implanted device and the host. Thus, much more importance has been given to study and modify the biomaterial surfaces to improve biocompatibility, cell adhesion, proliferation and differentiation. During the last years the research has evolved from the improvement of bulk properties and design of the implants to the development of a variety of bio-functional surface modifications, such as surface topography at both micro and nanoscale, adhesion of growth factors or coating deposition. The use of coatings allows the synthesis of hybrid materials, in which surface and bulk properties are de-coupled, so different functionalities (biocompatibility, antibacterial, etc...) could be obtained using the same substrate material. Materials: Metal oxide coatings (TiOx, ZrOx, TaOx and NbOx). Methods: The deposition of the coatings was done by reactive magnetron sputtering on stainless steel or titanium substrates. The coatings structure, composition and surface properties were measured. Electrochemical characterization using different electrolytes that simulate the biological fluids were used to evaluate the corrosion resistance provided by the coatings and the effect of the electrolyte composition on the response. The biological-surface interactions were also evaluated by studying protein-surface (adsorption), bacteria-surface (adhesion and biofilm formation) and cell-surface (adhesion, proliferation and differentiation) interactions. Discussion: The paper will presented a summary of the biological response from the four oxide coatings and the correlation between such response and the surface properties, including the effect of crystallinity or nanoroughness. One important factor to analyze is the fact that by using sputtered deposited coatings, it is possible to evaluate separately the effect of the surface chemical composition and the roughness, not so easily achieved when bulk materials are used. Conclusions: The in vitro results obtained from the different oxide coatings suggested that by using deposition methods, it is possible to create biomedical coatings that mimic the cellular response of the Ti-optimized metallic implants, with the advantage that such coatings could be deposited on hard-polymers or ceramics. UNAM PAPIIT Keywords: corrosion, Surface modification, surface property, Cell response Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Composites: polymeric, ceramic and metallic Citation: Rodil S, Silva-Bermudez P, Almaguer-Flores A and Olivares-Navarrete R (2016). Biomedical coatings prepared by magnetron sputtering. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01672 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Sandra Rodil Phaedra Silva-Bermudez Argelia Almaguer-Flores Rene Olivares-Navarrete Google Sandra Rodil Phaedra Silva-Bermudez Argelia Almaguer-Flores Rene Olivares-Navarrete Google Scholar Sandra Rodil Phaedra Silva-Bermudez Argelia Almaguer-Flores Rene Olivares-Navarrete PubMed Sandra Rodil Phaedra Silva-Bermudez Argelia Almaguer-Flores Rene Olivares-Navarrete Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.