In this paper, we first found a mixed resin with better adsorption effect than XAD-16 from 30 kinds of domestic resins. When two kinds of mixed resins (XD-5: D202=7:3) were mixed, the production of Ascomycetes So 2161 was produced. The yield of epothilone A and B increased by 252% and 262%, respectively, compared to the yield of the macroporous adsorption resin XAD-16 alone. Then the effect of mixed resin on the synthesis of epothilone was further studied. It was found through research that the macroporous adsorption resin XD-5 has better adsorption capacity for epothilone. The anion exchange resin D202 significantly promoted the growth of the Sorangium cellulosum.