Synthesis Of Deuterium Research Articles

Synthesis of labelled histamine H2‐receptor antagonists I. Synthesis of deuterium, sulfur and tritium labelled cimetidine and metiamide by exchange

AbstractThe H2‐antagonists, metiamide and cimetidine were lahelled with deuterium and tritium in the 2‐position of the imidazole ring by the uncatalyzed exchange reaction with deuterium and tritium oxide at 100°C. The sulfur‐35 labelled metiamide was prepared by an exchange reaction with elemental sulfur‐35 in refluxing pyridine and by the reaction of 2[(4‐methyl‐5‐imidazolyl)methylthio]ethylamine with methylisothiocyanate‐35S in refluxing ethanol.

Synthesis of deuterium and tritium labelled derivatives of maleopimaric acid

AbstractA new hepatoprotective agent, N‐(2‐hydroxyethyl)‐maleopimarimidyl morpholide (RU18492) has been synthesised labelled with tritium at C‐3, C‐4a, C‐10 and in the C‐isopropyl group. The incorporation of tritium relies on the acid‐catalysed isomerisation of levopimaric acid (4) to abietic acid (2), which was then converted in three stages to (3).

ESCAPE OF α PARTICLES FROM A LASER-PULSE-INITIATED THERMONUCLEAR REACTION

A theoretical analysis is made of the escape of α particles generated in the synthesis of deuterium and tritium in a spherical plasma heated to a high temperature by laser radiation. Under these conditions an α particle is slowed down mainly by plasma electrons. Equations are obtained for the fraction of the energy carried away by α particles outside the reaction zone and this energy is found as a function of the dimensions, temperature, and density of the plasma.