Synthesis Of Β-ketoamides Research Articles

A new synthesis of β-keto amides by reduction of Passerini adducts

The Passerini reaction between glyoxals, isocyanides and acetic acid forms β-keto acyloxyamides, which are readily transformed in β-keto amides by reductive deacetoxylation with zinc. The versatility of this procedure, which allows introducing different groups both in position-3 and the amide nitrogen, makes it ideal for its use in diversity-oriented synthesis, in combination with subsequent complexity generation reactions.

A New Synthesis of β-Keto AmidesviaReaction of Ketone Lithium Enolates with Isocyanates

Abstract A series of s-ketoamides was prepared by a convenient new method involving addition of various isocyanates to the lithium enolates of acetophenone propiophenone and pinacolone.