Syndrome Research Articles

Newborn with Multiple Congenital Anomalies (MCAs)

Congenital anomalies are one of the main causes of physical disabilities, stillbirths and neonatal deaths. It Can contribute to long-term disability, which may have significant impacts on individuals, families, health-care systems and societies. Diagnosis of a child who presents with multiple congenital anomalies both prenatal and postnatal is still a complex issue. We present a complex case of a newborn with multiple congenital anomalies (MCAs) including hydrocephalus, Down syndrome, phocomelia, ectrodactyl and ambiguous genitalia. This is the first case to be reported in Tanzania and among the few cases in World’s English literatures. Key words: Congenital, Hydrocephalus, Down syndrome, Phocomelia, Ectrodactyl ,Ambiguous genitalia

Low Bone Mineral Density and Immunological Insights in Postmenopausal Women Affected by Primary Sjandouml;grenandrsquo;s Syndrome

Objective: Osteoporosis is the pathological reduction of bone mineral density (BMD) and the most represented metabolic skeletal disease among population. A reduction in bone mineralization levels is associated with an increased risk of frailty fractures and of healthcare costs. Although there are many evidences bridging rheumatological diseases (such Systemic Sclerosis, Lupus Erythematosus Systemics and Rheumatoid Arthritis) with bone loss, very scarce and contradictory papers evaluate bone health in primary Sjogren's syndrome (pSS). Aim of this retrospective study is to evaluate BMD in pSS and its relationship with inflammatory markers, Ro/SSA and La/SSB antibodies. Methods: Fifty-three postmenopausal pSS were matched with 93 controls and studied for BMD measured by Dual Energy X- ray absorptiometry (DXA). Anti-nuclear antibodies (ANA), anti-extractable nuclear antigens (ENA), Anti- Ro/SSA, and anti-La/SSB antibodies, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were collected too. Mean BMDs of each explored region was compared and osteoporosis’s (OP) prevalence was assessed. Pearson’s analysis and multivariate regression models were built to highlight variables interrelations. Results: BMD was lower in pSS compared to controls, both expressed as g/cm2 and T-score considering lumbar spine and femoral neck. OP prevalence was higher among pSS compared to controls. Weight acted as the best predictor of lumbar BMD in multivariate model. No difference on BMD status was found between pSS with antibodies positivity and altered inflammatory markers with subjects displaying normal sera levels of the abovementioned variables. Conclusions: pSS female patients in an early stage of disease have lower BMD compared to healthy controls. Anti- Ro/SSA and anti/La antibodies and inflammatory markers are not related with BMD.

Associação entre deficiências nutricionais e sarcopenia em idosos: uma revisão integrativa

A sarcopenia é caracterizada pela redução da massa muscular, associada à diminuição da força muscular ou desempenho físico e se apresenta como um importante problema que acomete os indivíduos ao longo dos anos. No contexto atual, a nutrição e a atividade física vêm se destacando como pilares importantes para a prevenção e tratamento desta síndrome da fragilidade. O estudo teve como objetivo analisar o consumo alimentar de idosos e sua relação com o diagnóstico de sarcopenia, observando quais os principais nutrientes que estão envolvidos nesse processo. Trata-se de uma revisão integrativa, com busca sistemática, realizada por meio das bases de dados Pubmed; Biblioteca científica Scientific Eletronic Library Online (SCIELO); Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Web of Science. Os termos de busca foram “Elderly, Nutrients, Sarcopenia e Eating”. Inicialmente, obteve-se um quantitativo de 530 publicações, após avaliação criteriosa a amostra final constou de 6 artigos. Apesar da falta de padronização dos estudos, observou-se que o consumo de proteínas, micronutrientes e minerais inadequados em especial vitamina D, E, A, B, magnésio, selênio, potássio, cálcio e zinco estão envolvidos no diagnóstico de sarcopenia, bem como um padrão mediterrâneo de alimentação está associado a um risco reduzido. Enfatiza-se a necessidade de estudos utilizando métodos padronizados a fim de possibilitar comparações mais confiáveis entre os resultados e de caráter longitudinal.

Sweet Syndrome is associated with neoplasms. Report of a case.

El Síndrome de Sweet es una entidad que se manifiesta clínicamente por la presencia de placas eritematosas, pústulas y/o ampollas. En la histología se evidencia un denso infiltrado de neutrófilos. Al igual que otras dermatosis neutrofílicas, se caracteriza por una buena respuesta al tratamiento con esteroides y dapsona. En el 20% de los casos se asocia a enfermedades malignas, representando las hematológicas el 85% y los tumores sólidos el 15% restante. Se presenta una paciente de 46 años de edad con antecedentes de Leucemia Linfoblàstica, que consultó por la aparición de placas eritematosas, violáceas en el dorso de las manos con un estudio histopatológico que evidenció un Síndrome de Sweet. Palabras claves: Neutrofilia, vasculitis, Síndrome de Sweet.

Case vignettes and other brain teasers of monoclonal gammopathies.

There are a number of rare monoclonal gammopathies that do not have a characteristic laboratory, imaging, or pathologic study. Recognition requires keeping the specific syndrome in mind. This article reviews 6 rare syndromes associated with monoclonal proteins and gives specific "pearls" so a clinician can be certain not to overlook these important disorders that easily can be misdiagnosed as MGUS, Waldenstrom, and multiple myeloma.

Association between Transmission Season and Degree of Severity in Guillain-Barre Syndrome

Association between Transmission Season and Degree of Severity in Guillain-Barre Syndrome

Гендерная оценка развития острого инфаркта миокарда у пациентов с метаболическим синдромом

Введение. В последнее время сообщается о неуклонном росте числа пациентов, страдающих метаболическим синдромом (МС). Известно, что развитие МС может ускорять прогрессирование заболеваний сердечно-сосудистой системы, у таких пациентов отмечается повышение частоты сердечно-сосудистых событий, включая внезапную сердечную смерть. МС также неблагоприятно влияет на течение острого коронарного синдрома (ОКС), способствует развитию инфаркта миокарда (ИМ) у данных пациентов.Цель. Изучение гендерных особенностей развития ИМ у пациентов с ОКС на фоне МС. Материалы и методы. В исследовании приняли участие 50 человек. Пациенты были разделены на две группы: мужчины (n=25) и женщины (n=25) с МС, которые были экстренно госпитализированы в стационар с диагнозом острый коронарный синдром (ОКС) с подъемом ST. У всех обследованных изучали данные анамнеза, клинического, биохимического анализов крови, коагулограммы, уровни артериального давления (АД), данные электрокардиограмм (ЭКГ) в динамике.Результаты и обсуждение. Средний возраст в группе мужчин составил 56,9±9,4 года; у женщин – 67,4±7,3 года и был достоверно больше, чем у мужчин (р<0,05). Средний вес в группе мужчин был равен 89,9±10,4 кг, в группе женщин – 90,3±8,7 кг, статистически значимых отличий выявлено не было. Артериальная гипертензия в группе мужчин была выявлена у 88% пациентов, в группе женщин – у 92%. Различий по частоте артериальной гипертензии и уровням артериального давления в группах выявлено не было (р>0,05). Сахарный диабет 2-го типа достоверно чаще встречался у женщин с МС (р<0,05). Повышенный уровень С-реактивного белка (СРБ) обнаружен у 64% мужчин и 72% женщин. Повышение КФК-МВ выявлено у 48% пациентов мужского и 64% женского пола. Повышение СРБ у пациентов с МС было ассоциировано с гипергликемией. У пациентов с МС при развитии ОКС четырехкомпонентный МС встречался чаще, чем трехкомпонентный. У женщин с МС выявлено более частое повышение уровня тропонина и развитие ИМ. Для мужчин с МС была более характерна задняя локализация ИМ, у женщин чаще встречались передние ИМ.Заключение. В ходе проведенного исследования были получены данные о компонентном составе МС у пациентов с ОКС и гендерных особенностях развития ИМ у этой группы пациентов. Introduction. The number of patients with metabolic syndrome (MS) has been increasing recently. The development of MS can accelerate the progression of cardiovascular disease; and such patients have an increased risk of cardiovascular events, including sudden cardiac death. MS also adversely affects the course of acute coronary syndrome (ACS) and contributes to the development of myocardial infarction (MI) in these patients.Purpose. The aim of the study was to evaluate gender-related features of the development of MI in patients with ACS and MS.Materials and methods. 50 patients were included in the study. Patients were divided into two groups: men (n=25) and women (n=25) with MS, who were urgently hospitalized with ST-elevation ACS. All patients were examined for anamnesis data, clinical, biochemical blood tests and blood clotting tests, blood pressure (BP) levels, and electrocardiogram (ECG) data.Results and discussion. The mean age was 56.9±9.4 years in the group of men and 67.4±7.3 years in the group of women; women were significantly older than men (p<0.05). The body weight was not significantly different between the groups: 89.9±10.4 kg in the group of men and 90.3±8.7 kg in the group of women (p>0.05). Arterial hypertension was found in 88% of male patients and in 92% of female patients. There were no differences in its frequency and in the levels of blood pressure between the groups (p>0.05). Type 2 diabetes mellitus was significantly more prevalent in women with MS (p<0.05). Elevated levels of C-reactive protein (CRP) were found in 64% of men and 72% of women. The increase of CK-MB level was observed in 48% of men and 64% of women. The increase of CRP level in patients with MS was associated with hyperglycemia. Both in men and women with ACS, 4-component MS was more common than 3-component MS. Women with ACS and MS were more inclined to have the increased levels of troponin and to develop MI. Posterior localization of MI was more common in male patients, while anterior MI was more common in female patients.Conclusion. The study demonstrated the composition of MS in patients with ACS and gender- related features of MI development in this group of patients.

O processo de envelhecimento e sua relação entre sarcopenia, consumo de proteína e estado nutricional: uma revisão de literatura

O presente estudo objetivou realizar uma revisão integrativa sobre o processo de envelhecimento e sua relação entre sarcopenia, consumo de proteínas e estado nutricional. Para seleção das amostras foi estabelecido critérios de artigos indexados de 2015 a 2019 publicados em periódicos nacionais disponibilizados na íntegra em língua portuguesa e inglesa. A coleta de dados foi efetivada nas bases de dados eletrônicos: Scientific Electronic Library Online (SciELO), National Library of Medicine (PubMED) e o Google Acadêmico. Para o levantamento das pesquisas foram empregados os descritores: “sarcopenia”, “envelhecimento”, “consumo de proteínas” e “estado nutricional”. A busca resultou em 24 artigos pelos quais acometiam os descritores; restando 8 artigos para análise, interpretação e discussão, apóas a aplicação dos critérios de inclusão e exclusão. Nos estudos examinados percebeu-se que de todos os processos que acometem o ser humano o envelhecimento é o mais natural deles, no qual ocorrem alterações fisiológicas no organismo como um todo, e que existem dois tipos de envelhecimento descritos na literatura: fisiológico ou senescência e o patológico ou senilidade. Ao que segue, uma das alterações que afetam a funcionalidade que estão relacionadas ao envelhecimento patológico é a sarcopenia, que é uma síndrome caracterizada pela perda progressiva e generalizada de massa muscular e força, prevalecendo de 7% a 50% entre a população idosa. Dessa forma conclui-se que estreita relação entre consumo de proteína, estado nutricional e sarcopenia durante o processo de envelhecimento.

Assistência de enfermagem no pós-operatório imediato em transplantados cardíacos

Introdução: as cirurgias cardíacas são descritas como intervenções complexas exigem tratamento adequado em todas fases operatórias. Objetivo geral: realizar uma revisão da literatura para investigar a conduta do profissional de enfermagem no pós-operatório imediato no transplante cardíaco. Metodologia: para o desenvolvimento deste estudo foi realizada uma revisão da sistemática a com uma abordagem qualitativa, optando-se apenas por publicações com menos de 5 anos indexadas nas revistas na área de saúde. Resultado: as principais complicações mais comuns que os pacientes em pós-operatório por transplante cardíaco podem enfrentar em seu tempo de internação são, dor, dificuldade na troca de gases, débito cardíaco diminuído e risco para desequilíbrio de volume de líquido, arritmia cardíaca, instabilidade hemodinâmica e hipotermia. As apresentações pulmonares podem ser atelectasias, pneumonias, episódio de hipoxemia e a síndrome da angústia respiratória aguda. Portanto, o enfermeiro é extremamente importante, pois o profissional atua na avaliação hemodinâmica, avaliação da função renal e balanço hídrico; prevenção de infecções; detecção e tratamento de rejeição e garantir o suprimento adequado de nutrientes, além de fornecer recursos humanos e materiais. Sendo responsável por cuidar, controlar e observar o paciente, levando em consideração a complexidade da cirurgia.

Aspectos clínicos e principais formas de tratamento para Fibromialgia - Revisão de Literatura

A fibromialgia é considerada uma patologia incurável e uma síndrome idiopática por não ter sua fisiopatologia definida. O portador apresenta sintomas como dor crônica e generalizada, cansaço e dificuldade no sono. É considerada frequente e seu diagnóstico é realizado através da exclusão de outras patologias. Embora ainda não existe um tratamento efetivo, a terapia farmacológica auxilia os portadores a diminuírem os sintomas. O objetivo dessa revisão foi analisar a fisiopatologia envolvida no desenvolvimento da fibromialgia, bem como as terapias farmacológicas, plantas e compostos medicinais atualmente existentes e estudados para o tratamento desta patologia, considerando um período entre 2009 e 2020. Para tanto, os bancos de dados Scielo, Pubmed e Google Acadêmico foram consultados. Desse modo, pode-se constatar que as terapias farmacológicas existentes abrangem principalmente quatro classes de medicamentos que são as drogas antiepiléticas, antidepressivos tricíclicos, inibidores seletivos da recaptação de serotonina (ISRS) e inibidores da recaptação de serotonina noradrenalina, além de relaxantes musculares, benzodiazepínicos, antiinflamatórios analgésicos e fármacos fitoterápicos. Apesar das diversas diretrizes publicadas a respeito do tratamento da fibromialgia, até o momento inexiste terapia plenamente efetiva e diante disso evidencia-se a necessidade de novos fármacos específicos para essa patologia.

Expert consensus on special blood purification technics in patients with corona virus disease 2019

The outbreak of corona virus disease 2019 (COVID-19) has spread to more than 70 countries worldwide and there was a higher mortality in those who developed serious illness.Cytokine storm syndrome is an important pathophysiological basis for COVID-19 patients developing into severe or critical conditions. It was indicated in the diagnosis and treatment scheme, by the National Health Commission of the People's Republic of China, that blood purifications such as plasma exchange, plasma adsorption, hemoperfusion, hemofiltration and plasmafiltration could be considered for use in the critical patients with cytokine storm syndrome. This expert consensus, proposed by the Chinese Society of Nephrology and the Nephrology Committee of Chinese Research Hospital Association, is to guide and standardize the clinical application of blood purifications in the treatment of severe or critical patients with COVID-19.

Analysis of 3 death cases of critical COVID-19 in Sichuan

Objective To analyze the clinical characteristics of critical COVID-19, and we improve the understanding of the diagnosis and treatment of severe cases. Methods Death cases with critical COVID-19 in Public Health Clinical Medical Center of Chengdu from January to May 2020 were collected, and their clinical data and imaging features were retrospectively analyzed. Results The three cases of severe type COVID-19 deaths, all have basic diseases, such as coronary heart disease, with or without lung diseases, renal disfunction , they all have symptoms of fever, cough, sputum. Athospital admission, APACHE II score and PSI rating were high-risk, laboratory examination results suggested lactate dehydrogenase, creatine kinase, troponin, brain natriuretic peptide, C-reactive protein and serum amyloid A were significantly increased, and T lymphocyte count droped apparently, chest imaging suggested pulmonary grinding glass patch shadow. After admission, the patients were given active antiviral, anti-bacterial, immunological and invasive mechanical ventilation support. All 3 patients had severe complications such as septic shock and multiple organ failure syndrome, and the average time from onset to death was 13.7 days. Conclusion Old-age people combined with heart disease and other basic diseases, and immunodeficiency are the high-risk groups of critical COVID-19. 摘要：目的 分析危重型新型冠状病毒肺炎死亡病例的临床特征, 提高对重症病例诊治的认识。 方法 收集 2020 年 1 月—5 月成都市公共卫生临床医疗中心接诊的危重型新型冠状病毒肺炎死亡病例资料, 回顾性分析其临床资 料和影像学特征。 结果 3 例危重型 COVID-19 死亡病例均有冠心病、伴或不伴肺部疾病、肾功能障碍等基础疾病, 均 有发热、咳嗽、咳痰症状, 入院 APACHE II 评分和 PSI 评分均为高危, 实验室检查结果提示肌酸激酶、肌钙蛋白、脑钠肽、C-反应蛋白及血清淀粉样蛋白 A 明显升高, 而 T 淋巴细胞计数明显下降, 胸部影像学提示双肺磨玻璃斑片影。入院后 给予积极的抗病毒、抗细菌、增强免疫治疗及有创机械通气呼吸支持。3 例患者均并发脓毒性休克及多器官功能衰竭 综合征等严重并发症, 起病到死亡的平均时间为 13.7 d。 结论 高龄、合并心脏病等基础疾病、免疫功能低下者是危重 型新型冠状病毒肺炎死亡的高危人群。

Clinical characteristics analysis of patients with pneumonia infected by Chlamydia psittaci

To explore the clinical characteristics of pneumonia infected by Chlamydophila psittaci (C. psittaci). A retrospective analysis was performed on 3 cases of C. psittaci pneumonia admitted to People's Hospital of Tongling City from July 2019 to January 2020. The patients' contact history, clinical manifestations, laboratory examination, imaging characteristics and evolution, etiology, treatment process and outcome were analyzed, so as to provide experience for the diagnosis and prevention of C. psittaci pneumonia. The 3 patients had been infected through pet or zoonotic exposures. All symptoms included high fever (body temperature > 39 centigrade), cough, sputum, chest tightness and dyspnea. The disease progressed rapidly, with severe acute respiratory distress syndrome (ARDS) and shock as the main manifestations, but the damages to the heart, liver and kidney were mild. Laboratory tests showed that C-reactive protein (CRP, all > 200 mg/L) and neutrophil proportion (Neut%, > 0.90) were significantly increased, while white blood cell count (WBC) and procalcitonin (PCT) were not significantly increased. Chest computed tomography (CT) showed inflammatory infiltration with interstitial changes, either unilateral or bilateral. Chest X-ray showed large areas of inflammatory infiltrations, fan-shaped or wedge-shaped to the edge of pleura. After 7 days of treatment, the bedside computed X-ray (CR) showed absorption of infiltration. After 11-13 days, the CT reexamination indicated lung infection was basically absorbed. Metagenomic next-generation sequencing (mNGS) confirmed the presence of C. psittaci in patients' sputum. It was sensitive to quinolones and tetracyclines. The patients' body temperature dropped to normal after 2-3 days of antibiotics, and all patients were extubated and transferred to normal ward 10 days later. The total course of illness was 20-30 days. The patients with C. psittaci pneumonia are critically ill, and clinical manifestations of moderate to severe ARDS and shock are common. Early diagnosis depends on mNGS, and reasonable treatment is important for prognosis.

Early vascular aging risk assessment in patients with metabolic syndrome

Abstract Background Metabolic syndrome (MetS) and abdominal obesity are one of the most common CVD risk factors among young and mature patients. However, the currently used CVD risk assessment scales may underestimate the CV risk in people with obesity and MS. Early vascular aging rather than chronological aging can conceptually offer better risk prediction. MetS, as accumulation of classical risk factors, leads to acceleration of early vascular aging. Since an important feature of MetS is its reversibility, an adequate risk assessment and early start of therapy is important in relation to the possibilities of preventing related complications. Purpose To derive a new score for calculation vascular age and predicting EVA in patients with MetS. Methods Prospective open cohort study using routinely collected data from general practice. The derivation cohort consisted of 1000 patients, aged 35–80 years with MetS (IDF,2005 criteria). The validation cohort consisted of 484 patients with MetS and carotid-femoral pulse wave velocity (cfPWV) values exceeding expected for average age values by 2 or more SD (EVA syndrome). Results In univariate analysis, EVA was significantly correlated with the presence of type 2 diabetes and clinical markers of insulin resistance (IR), body mass index (BMI), metabolic syndrome severity score (MetS z-score), uric acid (UA) level, hsCRP, HOMA-IR, total cholesterol (TC), triglycerides (TG), heart rate (HR), central aortic blood pressure (CBP), diastolic blood pressure (DBP). Multiple logistic regression shown, that presence of type 2 diabetes and IR were associated with greater risk of EVA; the odds ratios were 2.75 (95% CI: 2.34, 3.35) and 1.57 (95% CI: 1.16, 2.00), respectively. In addition, the risk of having EVA increased by 76% with an increase in HOMA-IR by 1 unit, by 17% with an increase in hsCRP by 1 mg/l, by 4% with an increase in DBP by 1 mm Hg, and by 1% with each 1 μmol / L increase in the level of UA. The area under the curve for predicting EVA in patients with MetS was 0,949 (95% CI 0,936 to 0,963), 0,630 (95% CI 0,589 to 0,671), 0,697 (95% CI 0,659 to 0,736) and 0,686 (95% CI 0,647 to 0,726), for vascular age, calculated from cfPWV, SCORE scale, QRISK-3 scale and Framingham scale, respectively. Diabetes mellitus and clinical markers of IR (yes/no), HOMA-IR and UA level were used to develop a new VAmets score for EVA prediction providing a total accuracy of 0.830 (95% CI 0,799 to 0,860). Conclusion cfPWV at present the most widely studied index of arterial stiffness, fulfills most of the stringent criteria for a clinically useful biomarker of EVA in patients with MetS. Although, parallel efforts for effective integration simple clinical score into clinical practice have been offered. Our score (VAmets) may accurately identify patients with MetS and EVA on the basis of widely available clinical variables and classic cardiovascular risk factors can prioritize using of vascular age in routine care. ROC-curves for predicting EVA in MetS Funding Acknowledgement Type of funding source: None

P.836Metabolic syndrome and long-acting injected (LAI) preparations in schizophrenia: a "real-world" study

P.836Metabolic syndrome and long-acting injected (LAI) preparations in schizophrenia: a "real-world" study

Extracorporeal Membrane Oxygenation for COVID-19

Some patients with COVID-19 and acute respiratory distress syndrome (ARDS) develop refractory hypoxemia that warrants consideration of extracorporeal

Ticagrelor vs. Clopidogrel in Real-Life Patients with Acute Coronary Syndromes: Another View

Current guidelines recommend aspirin and ticagrelor over clopidogrel for patients with acute coronary syndrome (ACS) undergoing percutaneous coronary

Mediterranean diet and risk of Sjögren's syndrome.

OBJECTIVES Non-genetic risk factors for Sjogren's syndrome (SS) are poorly understood. Adherence to a Mediterranean diet has been associated with reduction in other autoimmune diseases. We examined the association of Mediterranean diet with SS. METHODS New patients attending a single centre warranting investigation for primary SS (pSS) were recruited into the Optimising Assessment in Sjogren's Syndrome cohort established in Birmingham, UK (2014-2018). Participants were classified into pSS and non-SS sicca, considered as cases and non-cases, respectively, and asked to complete an optional food frequency questionnaire on their diet before onset of symptoms. A semi-quantitative Mediterranean diet score (MDS) was calculated (possible range=0 to 18). Using multivariate logistic regression, corrected for energy intake, body-mass index, sex, age, symptom duration, and smoking status, we examined the association of MDS with SS. RESULTS Dietary data were available for 133/243 (55%) eligible patients (n=82 pSS and n=51 sicca). In the adjusted model, a higher total MDS (mean ± SD, 9.41±2.31 points) was associated with lower odds of pSS (OR 0.81, 95% CI 0.66-0.99; p=0.038) per one unit of MDS. Among MDS components, the strongest association was seen with fish with OR 0.44 (95% CI 0.24-0.83; p=0.01) in the comparison between <1 portion/week and 1 to 2.5 portions/week. Higher galactose, vitamin A-retinol-equivalents and vitamin C showed associations with lower odds of pSS in multivariate analysis, where the association of vitamin C was attenuated when adjusted for MDS. CONCLUSIONS When adjusted for potential confounders, adherence to the Mediterranean diet was associated with lower likelihood of having pSS.

Adult Multisystem Inflammatory Syndrome Associated with COVID-19

A multisystem inflammatory syndrome associated with SARS-CoV-2 infection has been defined in some children (MIS-C). Researchers now report on 27 cases

Restless legs syndrome in patients with chronic obstructive pulmonary disease

Introduction: Chronic obstructive pulmonary disease is one of the leading causes of death. Restless Legs Syndrome is associated with many systemic diseases. RLS is found in many patients with COPD. There is paucity of data on this topic from India.Aim: The aim is to find the prevalence of RLS in COPD patients and its distribution in study population with respect to various demographic and clinical characteristics. Correlation between severity of RLS and COPD severity was also aimed to be evaluated.Setting and design:Prospective, observational study conducted in a tertiary care institute over a period of 12 months. Materials and methods:After fulfilling the inclusion criteria the patients were categorised according to the severity of COPD using the GOLD guidelines. Diagnosis and severity of RLS was evaluated using IRLSSG criteria. Prevalence and association of RLS with COPD and its demographic and clinical characteristics was evaluated. Results:A total of 294 patients were taken which included 229(77.9%) males and 65 females (22.1%).Mean age was 62.05 ± 10.32 years. Smoking was a more common risk factor among the patients (85.7%). 110 patients were diagnosed with RLS. A statistical significant association was found between duration of COPD and RLS (p value =0.001) and also between severity of COPD and RLS (p value=0.001). A significant positive correlation (r=0.395, p value= 0.001) between severity of COPD and RLS. Forty two (87.5%) patients with definite RLS had stage D COPD. Degree of obstruction of airways showed a statistical significant association with prevalence of RLS (p value=0.001). Conclusion: RLS showed increased prevalence in COPD patients making it crucial to screen all the COPD patients for symptoms of RLS and if required to treat the symptoms, thus improving the quality of life.