Yang Deficiency Syndrome Research Articles

Mathematical analysis of the relationship between yang deficiency syndrome in traditional Chinese medicine and its objective indicators in clinical literature

The primary aim of this research is to systematically sort out and analyze available documents for yang deficiency syndrome in traditional Chinese medicine, providing innovative ideas and methods for statistical study of yang deficiency syndrome. Based on the China National Knowledge Internet (CNKI) and Chongqing VIP databases, using "yang deficiency", "deficiency cold", and "patient" as keywords, we searched literature of clinical researches and used "ratio-comparison" and "integration-comparison" to analyze objective data after data preprocessing. Relative importance value of physiological and biochemical parameters were reflected by P value calculated by ratio-comparison or Q value by integration-comparison. With calculation of relative importance values of clinical indicators among various systems, we got the ranking of relative importance of different indexes. Triiodothyronine and urine 17-hydroxycorticosteroid of endocrine system, immunoglobulin A of immune system, and the ratio of cyclic adenosine monophosphate to cyclic guanosine monophosphate, which had great |P| (or |Q|) values and negative P (or Q) values, had a clearly lower level in yang deficiency patients than in the control; hemorheological indicators such as plasma viscosity, whole blood reduced viscosity and erythrocyte electrophoresis time had small |P| (or |Q|) values. These indicators, however, showed less importance for reflecting yang deficiency. Ratio-comparison method and integration-comparison method employed in this study have merits of efficiency and robustness. After detailed compiling and mining of all available data, we have made reasonable advice on the most relevant index of yang deficiency for further study of the essence of this syndrome.

Prof. ZHANG Yi's Experience in Treating Severe Arrhythmia

The prescription of Zhi Gan Cao Tang (? Decoction of prepared Licorice) is made for the syndrome of both yin and yang deficiency of the Heart, with the effects of tonifying yin and nourishing blood, activating yang and restoring normal pulse, and evenly tonifying yin and yang. However, in clinical practice, the symptoms may vary greatly. The heart rate may be slow or fast; and the symptoms may belong to the cold or heat, excess or deficiency syndrome. Therefore, the treatment should be based on syndrome-differentiation. We can learn from the above sample cases. The two patients with bradycardia needed to carry pacemaker. Their TCM differentiations were different, one due to insufficiency of yang-qi should be treated based on the principle of restoring yang from collapse; while the other due to obstruction of collaterals by phlegm and blood stasis should be treated based on the principle of resolving phlegm, promoting circulation of blood and dredging the collaterals. However, they used the same prescription of Zhi Gan Cao Tang (? Decoction of prepared Licorice) with different modifications, and both of them got quite good therapeutic effects. We can also learn from the other three cases of tachycardia. Based on western medical analyses, the 3 patients had different etiology, clinical manifestations, and ECG findings. However, they were treated with the same prescription of Zhi Gan Cao Tang (? Decoction of prepared Licorice), with modifications made according to the different accompanying symptoms. As a result, all of the three patients got marked therapeutic effects.

Treatment with Aconitum Lizhong Pill down-regulates liver energy charge in rats with Spleen Yang Deficiency syndrome

Treatment with Aconitum Lizhong Pill down-regulates liver energy charge in rats with Spleen Yang Deficiency syndrome

Therapeutic effects of modified Danggui Sini Decoction on plasma level of advanced glycation end products in patients with Wagner grade 0 diabetic foot: a randomized controlled trial

Many studies have demonstrated association between advanced glycation end products (AGEs) and diabetic angiopathy. There are certain advantages of traditional Chinese medicine (TCM) therapy in treatment of these diseases. To evaluate the therapeutic effects and safety of modified Danggui Sini Decoction, a compound traditional Chinese herbal medicine for nourishing blood to warm meridians, on plasma level of AGEs in patients with Wagner grade 0 diabetic foot ulcers of blood stasis or/and kidney yang deficiency syndrome. A random and positive control method was adopted. Seventy-two cases of Wagner classification of grade 0 diabetic foot ulcers with blood stasis or/and kidney yang deficiency syndrome were randomly divided into treatment group and control group. There were thirty-six cases in each group. All the patients were collected from Maoming Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine. Patients received oral and written information about the clinical procedures before giving their written informed consent. The study was approved by the Ethics Committee of Maoming Hospital of Traditional Chinese Medicine. The patients in the treatment group were treated with modified Danggui Sini Decoction, and the patients in the control group were treated with cilostazol. A course of treatment was 14 days, and the patients in the two groups were treated for 3 courses. The changes of clinical symptoms, ankle-brachial index (ABI), electromyography, lower extremity arteries measured by ultrasonic Doppler, fasting blood glucose, hemoglobin A1c, fibrinogen, and plasma level of AGEs were detected in the two groups before and after treatment. The safety of modified Danggui Sini Decoction was assessed by laboratory data and adverse events. There were statistical differences in clinical efficacy, ABI, lower extremity arteries hemodynamics, and nerve conduction velocity between the two groups (P<0.05, P<0.01). The plasma level of AGEs after treatment was significantly decreased in the two groups, and the level of AGEs in the treatment group was lower than that in the control group (P<0.05). Modified Danggui Sini Decoction can improve clinical symptoms in patients with diabetic foot ulcers of Wagner grade 0 and it shows therapeutic effects on diabetes complicated with vascular diseases.

The Clinical Observation on the Treatment 100 Cases of Smaller Renal Calculus with Liuwei Dihuang Wan plus Jinkui Shenqi Wan

Objectives To study the clinical results of Liuwei Dihuang Wan plus jinkui Shenqi Wan treating small renal calculus (diameter< 1.0cm) which are not suitable for surgical operation. Methods 200 eases were randomly recruited into a control group and a treatrnent group, with 100 cases in each group. 100 cases in the treatment group was further enrolled into team A (having the syndrome of kidney Yin deficiency) and team B (having the syndrome of kidney yang deficiency), with 50 eases in each team. Team A and team B was treated with Liuwei Dihuang Wan and Jinkui Shenqi Wan respectively. The control group was treated with drugs that removing urinary calculus. Results The cure rate and the effective rate in team A was 60% and 86% respectively; and 62% and 88% respectively in team B. The total cure rate and effective rate of the treatment was 61% and 87% respectively. On the other hand, the cure and effectively rate of the control group was 7% and 35% respectively. The difference between the two groups were significant (P<0.01). Conclusion Liuwei Dihuang Wan plus jinkui Shenqi Wan has good effect in treating small renal calculus. Key words: Renal calculus, Liuwei Dihuang Wan; Jinkui Sbenqi Wan

쇼그렌 증후군 환자에서의 단백뇨 치험 1례

Objective Sjogren`s Syndrome is a chronic inflamatory disorder characterized by lymphocytic infiltration of lacrimal and salivary gland. It may be associated with renal disease such as tubulonephritis or glomerulonephritis. Proteinuria is a kidney disorder resulting in an abnormally high amount of protein in the urine. When the glomeruli are damaged, proteins of various sizes pass through them and are excreted in the urine. This report is a case of proteinuria with Sjogren`s Syndrome. Methods The patient was diagnosed as kidney yang deficiency syndrome and treated with Woogyu-eum, Sa-am acupuncture therapy and bee venom acupuncture therapy. Visual Analog Scale was used to estimate the clinical symptoms. Results Clinical symptoms and proteinuria were improved without steroid therapy. Conclusion Therefore, we concluded that oriental medical therapy may be useful to treat proteinuria with Sjogren`s Syndrome.

Correlation between syndromes of posthepatitic cirrhosis and biological parameters: a report of 355 cases

To investigate the pathological factors of syndrome pathomechanism through studying the correlation between syndromes of posthepatitic cirrhosis and biological parameters. Clinical information of three hundred and fifty-five patients with posthepatitic cirrhosis was collected and the database was established. Parameters with statistical significance were analyzed with multi-factor regression analysis to investigate the main influencing factors of the syndromes of posthepatitic cirrhosis. Formulae of six syndromes, including syndrome of yin deficiency of liver and kidney, syndrome of damp heat, syndrome of stagnated heat smoldering, syndrome of yang deficiency of spleen and kidney, syndrome of stagnation of liver qi and spleen deficiency and syndrome of blood stasis due to qi deficiency, were established with stepwise regression analysis. One of the pathophysiological bases of syndrome of blood stasis due to qi deficiency in cirrhosis is synthetic dysfunction of hepatocytes. The pathophysiological basis of syndrome of damp heat is inflammatory injury, which is also syndrome of stagnated heat smoldering in cirrhosis patients. The relationship between syndrome of yin deficiency of liver and kidney and stasis and damp heat may be the pathophysiological basis of the posthepatitic cirrhosis..

Effects of Kanlijian on exercise tolerance, quality of life, and frequency of heart failure aggravation in patients with chronic heart failure

To observe the effects of conventional therapy combined with Kanlijian (KLJ) on exercise tolerance, quality of life and frequency of heart failure aggravation in patients with chronic heart failure (CHF). Sixty CHF patients differentiated as sufferring from the syndrome of Xin-Shen Yang deficiency were included in the study and randomly assigned at the ratio of 2:1 into the KLJ group (n = 39) and the control group (n = 21). All the patients were treated with conventional therapy of Western medicine, but to those in the KLJ group, KLJ was medicated additionally one dose daily with 24 wks as one therapeutic course. The efficacy on TCM syndrome and changes of scores on TCM syndrome were observed after treatment. The indexes, including 6-minute walking distance (6MWD), quality of life (QOL, accessed by LHFQ scoring), NYHA grade, hemodynamic indexes and reducing/withdrawal rate of diuretic and digoxin before and after treatment were recorded and compared. Also the frequency of re-admission due to aggravation of heart failure in one year's time were observed. (1) The efficacy on TCM syndrome, improvement on scores of TCM syndrome, therapeutic effects on 6MWD, QOL, and NYHA grade in the KLJ group were superior to those in the control group. (2) Hemodynamic indexes after treatment, left ventricular fractional shortening (LVFS) and E peak/A peak (E/A), between the two groups had no significant difference, while left ventricular ejection fraction (LVEF) was increased significantly in the KLJ group, but with no obvious change in the control group. (3) The reducing/withdrawal rate of diuretic and digoxin in the KLJ group was significantly higher than that in the control group. (4) The 1-year frequency of re-admission significantly decreased in the KLJ group. The adjuvant treatment of KLJ on the basis of Western conventional therapy can significantly improve CHF patients' exercise tolerance, quality of life and cardiac function, reduce the dosage of diuretic and digoxin needed, and decrease the re-admission frequency due to aggravation of heart failure.

Clinical study of shengxue mixture (生血合剂) in treating aplastic anemia

To observe the clinical effect of Shengxue mixture (SXM) in treating aplastic anemia, and studied its mechanism. Eighty-four patients of the treated group, those with Spleen-Kidney Yang deficiency Syndrome and Spleen-Kidney Yin deficiency Syndrome were treated with SXM-A and SXM-B respectively, and 30 patients of the control group were treated with Stanozolol. The clinical effect and several experimental parameters were also observed. The basic cure rate, remission rate, total effective rate of the treated and control group were 21.43%, 27.38%, 86.90% and 3.33%, 20.00%, 56.67% respectively, the difference between 2 groups was significant (P < 0.05, P < 0.01). The effect of the treated group was obviously better than that of the control group. While the patients' symptoms were alleviated, the peripheral blood cells increased, the ratio of T lymphocyte subsets tended to balance, the level of natural killer cells activity increased, interleukin 2 reduced, and the reproduction of the bone marrow were markedly improved in most of the patients treated by SXM. SXM is an effective and safe drug for aplastic anemia. Its mechanism might be regulating the immune function, which facilitated the recovery of the bone marrow hematopoiesis function.

Treatment of severe cholestatic hepatitis by integrating traditional Chinese and Western medicines

To study the curative effect of Chinese medicine in treating severe cholestatic-hepatitis (SCH). Three hundred and fifty patients of SCH with total bilirubin level > or = 171 mumol/L were treated with Chinese medicines. For those with Blood Stasis Syndrome, treated with the recipe mainly consisted of Radix Paeoniae Rubra, and for which accompanied with blood Heat, fluid retention in epigastric region. Dampness dissenubated in Sanjiao ([symbol: see text]) or both Spleen and Kidney Yang-Deficiency Syndrome, the recipe was used in modification according to the Syndrome. Treatment was markedly effective in 288 cases and effective in 26 cases, the total effective rate being 89.7%. It is difficult in treating severe cholestatic hepatitis, especially the chronic cholestatic hepatitis, which could develop to severe chronic hepatitis if the jaundice lasted for a long time. This study showed a good effect of Chinese herbal medicine in eliminating jaundice.

On glucocorticoid receptors of peripheral leucocytes in patients with Yang-Deficiency

The leucocytic glucocorticoid receptors (GCR) were estimated in 20 patients with Yang-Deficiency Syndrome using a radioligand binding method and plasma cortisol was measured at the same time. Results showed that the levels of plasma cortisol and leucocytic GCR of patients were all significantly lower than the healthy control group, and the changes were more significant in 10 cases of hypofunction of endocrinopathy with manifestation of Yang-Deficiency and Yang-Deficiency patients aged <40 years. The mechanism and relationship between GCR and plasma cortisol were also discussed in this article.