PurposeThe purpose of this study was to describe maternal-infant feeding interactions among dyads with opioid exposure. DesignAn exploratory descriptive design was used to describe feeding interactions between mothers with opioid use disorder (OUD) and their infants being treated for neonatal opioid withdrawal syndrome (NOWS) in the neonatal intensive care unit (NICU) in a secondary analysis. MethodsEligible mothers had an infant in the NICU being treated for withdrawal, were English-speaking, and at least 18 years old. Videos were recorded in the infant's private room. There were 12 dyads analyzed for this study. The Mother-Infant Feeding Tool (MIFT) was used to assess regulatory processes in maternal-infant interactions. ResultsMothers spent most of the time monitoring the feeding, rather than being unfocused. Infants displayed dysregulated tone for about half of the feeding time. This is a preliminary study with further research needed to provide evidence of validity in this population.