Synchronous Triple Cancer Research Articles

A Case Report of Synchronous Triple Cancer Resected Simultaneously

We report a unique case of a patient with synchronous renal cell carcinoma, hepatocellular carcinoma and squamous cell carcinoma of the oral floor. All three tumors were resected during a single operation. The patient was a 75-year-old man with masses in the liver and right kidney discovered by ultrasound examination during a routine checkup. Further examination also revealed a squamous cell carcinoma of the oral floor. The patient underwent a simultaneous radical nephrectomy, enucleation of the liver tumor and resection of the tumor of the oral floor. The diagnoses were histopathologically confirmed. The number of patients with multiple cancers has recently been increasing. The possibility of a second or third malignant lesion should be considered, not only in patients with a known malignancy but also in those without malignancy. The importance of screening procedures in the early detection of malignancy before the appearance of clinical symptoms should be emphasized.

A CASE OF SYNCHRONOUS DOUBLE CANCER OF THE ESOPHAGUS AND GALLBLADDER SUCCESSFULLY DIAGNOSED PREOPERATIVELY

A 77-year-old man, who had been treated for pulmonary tuberculosis and bronchial asthma at a nearby hospital, noticed right hypochondralgia in May 1992. Ultrasonography indicated gallstone and a gallbladder tumor and he was referred to the hospital. With examinations a diagnosis of synchronous double cancer of the esophagus and gallbladder was made. Because of his advanced age and pulmonary complications, closed heart evultion of the esophagus with cervical esophagus-gastric tube anastomosis and extended cholecystectomy with lymph node dissection (R2) were performed. The esophageal tumor was well differentiated squamous cell carcinoma with wall invasion of sm; while the cystic tumor was adenosquamous cell carcinoma with wall invasion of ss and n2(+) in stage III. Postoperatively suture failure and respiratory failure developed, but which were successfully managed and the patient was discharged from the hospital on 170th hospital day. Synchronous double cancer of the esophagus and gallbladder is rare, and only 6 cases including this case have been seen in the Japanese literature, which included 2 cases of synchronous triple cancer. Among them preoperative diagnosis could be achieved only in this case. It is said that double cancer of the esophagus and other organ has a poor prognosis because of the difficulty in treating esophageal cancer and coexistence of other organ cancer. For this reason the therapeutic guideline should be decided carefully.

AN OPERATED CASE OF SYNCHRONOUS TRIPLE CANCER

A case of synchronous triple cancer of the rectum, esophagus and stomach was experienced. A 72-year-old man underwent resection of the lower rectum with a diagnosis of rectal cancer (Rb). This was in stage II(al, n(-), PO, HO, M(-)), showing the histological feature of well differentiated adenocarcinoma. The second carcinoma, an esophageal cancer, was diagnosed about one month after the first operation. Biopsy specimen revealed squamous cell carcinoma. He underwent lower esophageal resection with reconstruction by esophago-gastrostomy. The third carcinoma a IIa type gastric cancer was very small, therefore strip biopsy was performed. Triple carcinomas seen in the literature are discussed.

A CASE OF SYNCHRONOUS TRIPLE CANCER

A case of synchronous triple cancer which involved the tongue, breast and esophagus was experienced. A 58-year-old woman underwent right partial resection of the tongue with a diagnosis of tongue cancer. This was in stage I showing the histological feature of well-differentiated squamous cell carcinoma. The second neoplasm, a right breast cancer, was diagnosed about two months after the first operation. A modified radical mastectomy was done (stage II), and the solid tubular carcinoma was histologically revealed. Around 4 months after the second operation for breast cancer, poor appetite and a gradual body weight loss occurred, and then 3 months later, an esophageal cancer was detected. Biopsy specimen revealed moderately differentiated squamous cell carcinoma in an advanced stage. It was inoperable. Systemic chemotherapy failed to cure and the patient died 6 months later. In this paper clinical course as well as flow cytometric DNA analysis of this synchronous triple cancer which was performed by using these paraffin-embedded tissues is described. Triple carcinomas seen in the literature are also discussed.

A autopsy case of synchronous triple cancers including gastric cancer, early urinary bladder cancer and malignant pleural mesothelioma with metastatic malignant mesothelioma of the stomach

A autopsy case of synchronous triple cancers including gastric cancer, early urinary bladder cancer and malignant pleural mesothelioma with metastatic malignant mesothelioma of the stomach

A case of synchronous triple cancers including gastric cancer, common bile duct cancer and multiple gallbladder cancers

A case of synchronous triple cancers including gastric cancer, common bile duct cancer and multiple gallbladder cancers

混合型肝癌に肺へん平上皮癌と大腸高分化型腺癌を併存した同時性異所性三重複癌の１例

混合型肝癌に肺へん平上皮癌と大腸高分化型腺癌を併存した同時性異所性三重複癌の１例