Synchronous Squamous Cell Carcinoma Research Articles

Neoadjuvant chemotherapy and irradiation in multiple synchronous squamous cell carcinoma of the upper aero digestive tract.

Twenty-four patients with multiple, synchronous carcinoma of the head and neck, lung or esophagus, were treated with induction chemotherapy followed by irradiation to involved areas. Chemotherapy regimen consisted of cisplatinum either alone, or in combination with 5-FU or etoposide. Subsequently, external radiotherapy, 60-65 Gy and 70-75 Gy to the mediastinum and the head and neck areas, respectively, was carried out. Following chemotherapy, three patients (12.5%) had a complete clinical remission in both cervical and mediastinal sites. That rate was significantly increased by radiotherapy (66%). Tolerance was fair or mild even though half of the patients needed a rest break during irradiation. Follow-up ranges from 24 to 38 months. The median survival is 12 months and the actuarial survival rates are 45% and 5% at 12 and 24 months, respectively. It is suggested that induction chemotherapy will not drastically improve the overall prognosis of multiple squamous cell carcinoma of the upper aero digestive tract and that external irradiation remains a major part of treatment which should not be reduced in treated volumes, or in total dose delivered.

Bilateral and synchronous squamous cell carcinoma of the cervix in a patient with uterus didelphys : Fox S; Mones JM; Kronstadt R; Saldana MJ Department of Obstetrics and Gynecology, Southeastern Medical Center, Southeastern College of Osteopathic Medicine and Surgery, Miami, FL 33162, USA Obstet. Gynecol.; 67/3 Suppl. (76S–79S) 1986

International Journal of Gynecology & ObstetricsVolume 25, Issue 2 p. 171-171 Citations from the literature oncology Bilateral and synchronous squamous cell carcinoma of the cervix in a patient with uterus didelphys Fox S; Mones JM; Kronstadt R; Saldana MJ Department of Obstetrics and Gynecology, Southeastern Medical Center, Southeastern College of Osteopathic Medicine and Surgery, Miami, FL 33162, USA Obstet. Gynecol.; 67/3 Suppl. (76S–79S) 1986 First published: April 1987 https://doi.org/10.1016/0020-7292(87)90025-7AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume25, Issue2April 1987Pages 171-171 RelatedInformation