Synchronous Node Research Articles

Virtual Wi-Fi for single hopping

Single hopping is implemented by using software approach over IEEE802.11WLAN card using orthogonality concept and protocol. Most feature of single hopping is to achieve virtual Wi-Fi network. Design parameters of this approach are time delay and energy consumption .There are many scenarios where a wireless device connect to virtual Wi-Fi network. In this paper we improve the energy consumption and reduce the switching delay over popular IEEE 802.11 WLAN and present the performance of virtual Wi-Fi for single hop ad hoc network in terms of delay and energy consumption. Finally we approached multihopping in an ad hoc network using channelization with node synchronization.

ER, HER2, and TOP2A expression in primary tumor, synchronous axillary nodes, and asynchronous metastases in breast cancer

ER, HER2, and TOP2A expression in primary tumor, synchronous axillary nodes, and asynchronous metastases in breast cancer

Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer and in lymph nodes metastases: a comparative immunohistochemical analysis

The immunophenotypic differences between primary and metastatic tumour cells could influence patient's treatment or/and the results of selected diagnostic procedures. That prompted us to investigate potential differences between primary tumours and corresponding synchronous lymph node metastases in the T  1/N+/M0 breast cancer patients. The investigated group consisted of 108 patients with invasive ductal breast cancer, who underwent radical surgery. The expression of ER, PR, HER2 as well as CK5/6, P-cadherin, EGFR and Ep-CAM was assessed immunohistochemically. Our data suggest that ER, PR, HER2, EGFR and CK5/6 are expressed conservatively, with some minor changes between primary tumour and simultaneous lymph node metastases. On the contrary, Ep-CAM and P-cadherin immunoreactivity in primary and metastatic cells varied significantly. This variation might exclude Ep-CAM and P-cadherin as potential diagnostic or therapeutic targets.

Adaptive Time Synchronization for Homogeneous WSNs

Wireless sensor networks (WSNs) are being used for observing real-world phenomenon. It is important that sensor nodes (SNs) must be synchronized to a common time in order to precisely map the data collected by SNs. Clock synchronization is very challenging in WSNs as the sensor networks are resource constrained networks. It is essential that clock synchronization protocols designed for WSNs must be light weight i.e. SNs must be synchronized with fewer synchronization message exchanges. In this paper, we propose a clock synchronization protocol for WSNs where first of all cluster heads (CHs) are synchronized with the sink and then the cluster nodes (CNs) are synchronized with their respective CHs. CNs are synchronized with the help of time synchronization node (TSN) chosen by the respective CHs. Simulation results show that proposed protocol requires considerably fewer synchronization messages as compared with the reference broadcast synchronization (RBS) protocol and minimum variance unbiased estimation (MUVE) method. Clock skew correction mechanism applied in proposed protocol guarantees long term stability and hence decreases re-synchronization frequency thereby conserving more energy.

Testing Synchrony in Historical Biogeography: The Case of New World Primates and Hystricognathi Rodents

The abrupt appearance of primates and hystricognath rodents in early Oligocene deposits of South America has puzzled mastozoologists for decades. Based on the geoclimatic changes that occurred during the Eocene/Oligocene transition period that may have favoured their dispersal, researchers have proposed the hypothesis that these groups arrived in synchrony. Nevertheless, the hypothesis of synchronous origins of platyrrhine and caviomorph in South America has not been explicitly evaluated. Our aim in this work was to apply a formal test for synchronous divergence times to the Platyrrhini and Caviomorpha splits. We have examined a previous work on platyrrhine and hystricognath origins, applied the test to a case where synchrony is known to occur and conducted simulations to show that it is possible to formally test the age of synchronous nodes. We show that the absolute ages of Platyrrhini/Catarrhini and Caviomorpha/Phiomorpha splits depend on data partitioning and that the test applied consistently detected synchronous events when they were known to have happened. The hypothesis that the arrival of primates and hystricognaths to the New World consisted of a unique event cannot be rejected

PP 96 NHERF1 in advanced colorectal cancer: its interaction with HIF-1α and TWIST1 plays an important role in synchronous lymph node and liver metastases

PP 96 NHERF1 in advanced colorectal cancer: its interaction with HIF-1α and TWIST1 plays an important role in synchronous lymph node and liver metastases

Clinical characterization of patients with metastatic colorectal cancer depending on the KRAS status

This retrospective study investigated the clinical characteristics of patients with metastatic colorectal cancer (mCRC) depending on the KRAS status, thereby differentiating KRAS exon 2 mutations in codon 12 versus codon 13. In total, 273 patients with mCRC receiving first-line therapy were analyzed. One hundred patients were treated within the FIRE-3 trial (FOLFIRI plus cetuximab or bevacizumab), 147 patients within the AIO KRK-0104 trial (cetuximab plus CAPIRI or CAPOX), and further 26 patients received therapy outside the study. Thirty-eight tumors with KRAS mutation in codon 13, 140 tumors with mutation in codon 12, and 95 tumors with KRAS wild type as a comparison were included in this analysis. Bivariate analyses demonstrated significant differences between KRAS wild-type, codon 12-mutated, and codon 13-mutated tumors with regard to synchronous lymph node metastasis (P=0.018), organ metastasis (76.8% vs. 65.9% vs. 89.5%, P=0.009), liver metastasis (89.5% vs. 78.2% vs. 92.1%, P=0.025), lung metastasis (29.5% vs. 42.9% vs. 50%, P=0.041), liver-only metastasis (48.4% vs. 28.8% vs. 28.9%, P=0.006), and metastases in two or more organs (49.5, 61.4, 71.1, P=0.047). Regression models indicated a significant impact of KRAS mutations in codon 12 versus codon 13 for synchronous organ and nodal metastasis (P=0.01, 0.03). This pooled analysis indicates that mCRC is a heterogeneous disease, which seems to be defined by KRAS mutations of the tumor. Compared with KRAS codon 12 mutations, codon 13-mutated mCRC presents as a more aggressive disease frequently associated with local and distant metastases at first diagnosis.

A direct sequence spread spectrum code acquisition circuit for wireless sensor networks

Narrow band (NB), spread spectrum (SS), and ultra wide band (UWB) are three physical layer bandwidth types used in wireless sensor networks (WSN). SS and UWB technologies have many advantages over NB, which make them preferable for WSN. Synchronisation of different nodes in a WSN is an important task that is necessary to improve cooperation and lifetime of nodes. Code acquisition is the main step of a node’s time synchronisation. In this article, a pseudo noise code generator and a code acquisition circuit are proposed, designed and tested using direct sequence SS technique. To investigate the properties of the designed circuits, simulations are carried out via Xilinx Foundation Series software in the real mode. The results demonstrate excellent performance of the proposed algorithms and circuits in all realistic conditions. The code acquisition circuit proposed an adaptive testing window for single dwell serial search method. The code acquisition circuit is a clock phase free approach, thus the clock coherency step is cancelled. Moreover, clock phase difference between transmitter and receiver nodes does not mostly affect the acquisition and thus synchronisation time.

ROC: Resilient Online Coverage for Surveillance Applications

We consider surveillance applications in which sensors are deployed in large numbers to improve coverage fidelity. Previous research has studied how to select active sensor covers (subsets of nodes that cover the field) to efficiently exploit redundant node deployment and tolerate unexpected node failures. Little attention was given to studying the tradeoff between fault tolerance and energy efficiency in sensor coverage. In this work, our objectives are twofold. First, we aim at rapidly restoring field coverage under unexpected sensor failures in an energy-efficient manner. Second, we want to flexibly support different degrees of redundancy in the field without needing centralized control. To meet these objectives, we propose design guidelines for applications that employ distributed cover-selection algorithms to control the degree of redundancy at local regions in the field. In addition, we develop a new distributed technique to facilitate switching between active covers without the need for node synchronization. Distributed cover selection protocols can be integrated into our referred to as “resilient online coverage” (ROC) framework. A key novelty in ROC is that it allows every sensor to control the degree of redundancy and surveillance in its region according to current network conditions. We analyze the benefits of ROC in terms of energy efficiency and fault tolerance. Through extensive simulations, we demonstrate the effectiveness of ROC in operational scenarios and compare its performance with previous surveillance techniques.

Energy saving with node sleep and power control mechanisms for wireless sensor networks

Energy efficiency sleep scheduling in wireless sensor networks is one of the most crucial technologies. In this paper, we propose a simple and feasible synchronous node sleeping and waking mechanisms for small scale wireless sensor networks. Sensor nodes are divided into forwarding nodes and listening nodes. Beacon frame containing sleep command from the coordinator can be forwarded to listening nodes via forwarding nodes. All the nodes in the network can enter sleep at about the same time. Through such network synchronization mechanisms, we can realize synchronous sleep and wake of the entire network. Furthermore, a new power control scheme based on routing protocol (PCBRP) in the medium access control (MAC) layer is proposed. It operates with the help of routing protocol and calculates optimal transmission power according to the distance between neighbor nodes. A mapping table including optimal transmission power and node address is established during the route building procedure. The transmission power can be obtained by searching the table with the address of next-hop neighbor in subsequent data transmissions. The proposed mechanisms are implemented in sensor nodes and are evaluated in a test-bed. The analysis and evaluation based on the experimental results confirm that the proposed energy-saving mechanisms are feasible and effective.

Lymphoepithelioma-like carcinoma of the vulva, an underrecognized entity? Case report with a single inguinal micrometastasis detected by sentinel node technique

This report describes an unusual EBV-negative lymphoepithelioma-like carcinoma of the vulva in a 73-year-old patient. The lesion was localised at the right minor labium and was resected by partial vulvectomy. A synchronous sentinel lymph node biopsy revealed a single micrometastasis in the right inguinal region, which prompted local radiotherapy. Follow-up nine months later showed only slight vulvar atrophy, without signs of local recurrence or distant metastases.Although lymphoepithelioma-like carcinomas of the skin and the female genital tract are presumed to have a better prognosis than their counterparts in the upper aerodigestive tract, possibly due to earlier detection and therapy, this case documents their potential for early metastasis.

Network-Wide Time Synchronization in Multi-Channel Wireless Sensor Networks

Recent advances in wireless sensor technology have enabled simultaneous exploitation of multiple channels in wireless sensor systems. In this paper, a novel time synchronization algorithm is proposed for multichannel Wireless Sensor Networks (WSNs) called Multi-Channel Time Synchronization (MCTS) protocol. Time synchronization is critical for many WSN applications and enables efficient communications between sensor nodes along with intelligent spectrum access. Contrary to many existing protocols that do not exploit multi-channel communications, the protocol takes advantage of potential multiple channels and distributes the synchronization of different nodes to distinct channels and thus, reduces the convergence time of synchronization processes significantly.

Network-Wide Time Synchronization in Multi-Channel Wireless Sensor Networks

Recent advances in wireless sensor technology have enabled simultaneous exploitation of multiple channels in wireless sensor systems. In this paper, a novel time synchronization algorithm is proposed for multi- channel Wireless Sensor Networks (WSNs) called Multi-Channel Time Synchronization (MCTS) protocol. Time synchronization is critical for many WSN applications and enables efficient communications between sensor nodes along with intelligent spectrum access. Contrary to many existing protocols that do not exploit multi-channel communications, the protocol takes advantage of potential multiple channels and distributes the synchronization of different nodes to distinct channels and thus, reduces the convergence time of synchronization processes significantly.

The theory of wavelet transform method on chaotic synchronization of coupled map lattices

The wavelet transform method originated by Wei et al. [Phys. Rev. Lett. 89, 284103.4 (2002)] was proved [Juang and Li, J. Math. Phys. 47, 072704.16 (2006); Juang et al., J. Math. Phys. 47, 122702.11 (2006); Shieh et al., J. Math. Phys. 47, 082701.10 (2006)] to be an effective tool to reduce the order of coupling strength for coupled chaotic systems to acquire the synchrony regardless the size of oscillators. In Juang et al., [IEEE Trans. Circuits Syst., I: Regul. Pap. 56, 840 (2009)] such method was applied to coupled map lattices (CMLs). It was demonstrated that by adjusting the wavelet constant of the method can greatly increase the applicable range of coupling strengths, the parameters, range of the individual oscillator, and the number of nodes for local synchronization of CMLs. No analytical proof is given there. In this paper, the optimal or near optimal wavelet constant can be explicitly identified. As a result, the above described scenario can be rigorously verified.

Partitioning of Bronchopulmonary Carcinoids in Two Different Prognostic Categories by Ki-67 Score

Introduction: Histological distinction between typical and atypical bronchopulmonary carcinoids is based on mitotic activity and necrosis. Regardless of these two parameters, outcome after surgery is often unpredictable. In this study the prognostic value of different clinico-pathological factors was retrospectively analyzed in a large series of patients with bronchopulmonary carcinoid. Materials and Methods: The long-term post-surgical outcome of 106 radically treated patients affected by bronchopulmonary carcinoid from two Italian centers was correlated with tumor characteristics assessed by combining conventional histology with a panel of immunohistochemical markers of neuroendocrine differentiation (chromogranin-A, NSE) and proliferation activity (Ki-67 score). Results: Carcinoids were assessed as typical (TC = 75; 70.8%) and atypical (AC = 31; 29.2%). Mean follow-up was 8.3 years (range: 0–20; median: 8.0). All cases expressed neuroendocrine markers. At univariate analysis, tumor recurrence [14/75 TC (18.7%), 15/31 AC (48.4%)] correlated with carcinoid histotype (P = 0.003), tumor size (P = 0.012), mitotic index (P = 0.044), Ki-67 score (P < 0.0001), and synchronous node metastasis (P = 0.037). Of these, Cox multivariate analysis confirmed only Ki-67 score as independent predictor of disease recurrence (P = 0.009). The best cut-off for Ki-67 score (calculated by ROC curves) discriminating recurrent vs non-recurrent disease was 4% (sensitivity 79.3%; specificity 83.8%; area under the curve 0.85). By stratifying patients according to this cut-off, a significantly different disease-free survival was found (log-rank test P < 0.0001). Conclusion: Ki-67 score accurately separates bronchopulmonary carcinoids in two well-distinct histo-prognostic categories. Ki-67 score predicts the patients outcome better than mitotic count, histotype, and tumor stage and it is therefore helpful in establishing the appropriate follow-up.

Indirect Localization and Imaging of Objects in an UWB Sensor Network

A method for the localization and the rough 2-D microwave imaging of objects is described. It detects and utilizes line-of-sight (LOS) paths between a mobile node and several fixed nodes of a distributed ultrawideband (UWB) sensor network. Objects are imaged in an indirect way, i.e., by a combination of maps, which show the distribution of LOS paths of individual network nodes. The method is demonstrated by means of ray-tracing simulations and measurements in a realistic environment. Performance limitation by diffraction and the question of temporal network node synchronization are discussed.

Quantum synchronization over quantum networks

We consider a network of quantum oscillators in which quantum states are distributed among connected nodes by means of unitary transformations. The distributed states interact with each local state according to a time-dependent interaction Hamiltonian, which is modeled by a Hermitian operator constructed in terms of the states themselves, thereby introducing nonlinear network interactions. For qubit nodes of differing natural frequencies, we show numerically that for a sufficiently large coupling constant, synchronization of quantum nodes occurs in which the spins of all qubits are mutually aligned with a common frequency of oscillation, following initial transient configurations. We discuss the significance of quantum synchronization as a means to create copies of unknown quantum states.

Transient and asymptotic behavior of synchronization processes in assembly-like queues

This paper analyzes the synchronization process of an assembly-like queueing system in which two distinct types of items/customers arrive at separate buffers, according to independent Poisson processes, so as to be synchronized into pairs at a synchronization node. Once a pair is synchronized it then queues up for service from a single server on a first-in-first-out basis as pairs. It is assumed that the service times of pairs are exponentially distributed and that the system has infinite capacity. Despite their practical significance, such queueing systems have not been adequately treated in the literature due to their transience or null recurrence. We first investigate the transient and asymptotic properties of the synchronization process’ first two moments, both analytically and numerically. Motivated by the observed asymptotic behavior, we then propose an M/M/1 approximation to describe the behavior of such assembly-like queueing systems. Finally, a numerical study of the proposed approximation reveals that it performs sufficiently well for practical applications.

Determining the role of external beam radiotherapy in unresectable intrahepatic cholangiocarcinoma: a retrospective analysis of 84 patients

BackgroundIntrahepatic cholangiocarcinoma (ICC) is the second most common type of primary liver cancer. Only few studies have focused on palliative radiotherapy used for patients who weren't suitable for resection by surgery. This study was conducted to investigate the effect of external beam radiotherapy (EBRT) for patients with unresectable ICC.MethodsWe identified 84 patients with ICC from December 1998 through December 2008 for retrospective analysis. Thirty-five of 84 patients received EBRT therapy five times a week (median dose, 50 Gy; dose range, 30-60 Gy, in fractions of 1.8-2.0 Gy daily; EBRT group); the remaining 49 patients comprised the non-EBRT group. Tumor response, jaundice relief, and survival rates were compared by Kaplan-Meier analysis. Patient records were reviewed and compared using Cox proportional hazard analysis to determine factors that affect survival time in ICC.ResultsAfter EBRT, complete response (CR) and partial response (PR) of primary tumors were observed in 8.6% and 28.5% of patients, respectively, and CR and PR of lymph node metastases were observed in 20% and 40% of patients. In 19 patients with jaundice, complete and partial relief was observed in 36.8% and 31.6% of patients, respectively. Median survival times were 5.1 months for the non-EBRT group and 9.5 months for the EBRT group (P = 0.003). One-and two-year survival rates for EBRT versus non-EBRT group were 38.5% versus 16.4%, and 9.6% versus 4.9%, respectively. Multivariate analysis revealed that clinical symptoms, larger tumor size, no EBRT, multiple nodules and synchronous lymph node metastases were associated with poorer prognosis.ConclusionsEBRT as palliative care appears to improve prognosis and relieve the symptom of jaundice in patients with unresectable ICC.

Silencing Heat Shock Protein 27 Decreases Metastatic Behavior of Human Head and Neck Squamous Cell Cancer Cells in Vitro

The small heat shock protein 27 (Hsp27) is a molecular chaperone that is involved in a variety of cellular functions in cancer cells. The purpose of this research is to study Hsp27 in vitro metastatic behaviors of head and neck squamous cell carcinoma cells (HNSCC). The expression of Hsp27 in primary and metastatic cell lines derived from the primary HNSCC and a synchronous lymph node metastasis in the same patient was determined using real-time PCR and Western blotting. Proliferation of the primary and metastatic HNSCC cell lines was evaluated using the MTS proliferation assay. Metastatic behavior was assessed using migration and invasion assays. SiRNA knockdown of Hsp27 was performed in the highly migratory metastatic HNSCC cell line. MTS assays showed that the primary (UM-SCC-22A) and metastatic (UM-SCC-22B) HNSCC have similar proliferation rates. However, UM-SCC-22B derived from the metastasis showed 2.3- to 3.6-fold higher migration ability and 2-fold higher invasion ability than UM-SCC-22A. Real-time PCR demonstrated that Hsp27 mRNA is 22.4-fold higher in metastatic UM-SCC-22B than primary UM-SCC-22A. Similarly, Western blotting showed that Hsp27 is rarely detectable in UM-SCC-22A whereas UM-SCC-22B expresses a 25-fold higher level of Hsp27 protein. SiRNA-mediated knockdown of Hsp27 in UM-SCC-22B reduced Hsp27 mRNA expression by nearly 6-fold and protein expression by 23-fold. Furthermore, siRNA knockdown of Hsp27 decreased metastatic behaviors of UM-SCC-22B by 3- to 4-fold in migration and 2-fold in cell invasion reducing cell invasion and migration to levels similar to the primary HNSCC UM-SCC-22A. These data indicate that Hsp27 may regulate metastatic potential of HNSCC cancer cells. Targeting Hsp27 may decrease metastasis in head and neck squamous cell cancer cells.