Background: Obesity is a risk factor for peripheral neuropathy (PN). PN is found in subjects with diabetes, pre-diabetes and metabolic syndrome. Bariatric surgery (BS) – most successful obesity treatment results in stable weight loss. Though, BS impact on PN is unknown. Aim: To investigate impact of weight loss on PN in type 2 diabetes (T2DM) post-BS by Sudoscan. Method: A male (51yrs), T2DM diagnosed 8yrs ago; pre-operative examination results: weight-145 kg, BMI-42kg/m2, HbA1c-10.2%, T/A -150/90mmHg (on ACE/Amlodipine); vitamins D/B12 - within the normal range. Patient was on intensive insulin therapy (sol. Glulisine, short-acting insulin/SAI+ sol. Glargine, long-acting insulin/LAI): LAI - 24 IU/at bedtime; SAI-12x12x12 IU / before main meals. Neuropathy tests/BNT (monofilament, tip-term, vibration tests) were moderately positive; Sudoscan revealed moderate PN (scores 50 feet/48 hands). Diagnosis: T2DM, diabetic neuropathy, obesity class III, AH II. Treatment: BS (sleeve-gastrectomy) was performed; dietary therapy, multivitamins, calcium citrate, iron, vitamins D/ B12 were initiated post-operatively. Results: Post-operatively weight loss and glycemic profile improved, insulin doses gradually reduced, finally insulin and antihypertensive therapy were stopped. Post-operative examination results (month 3): HbA1c-6.7%, BMI-33.2kg/m2, T/A -130/80 mmHg; no symptoms of high ABP and/or hyperglycemia. Neuropathic complains and test scores improved: BNT - weak positive; by Sudoscan - moderate neuropathy (scores 55 feet/50 hands). Vitamins D/B12 and ionized calcium levels - within normal range. Patient was physically active. Dietary therapy/physical activity continued. Examination results (month 6): HbA1c-5.9%, BMI-28.9kg/m2, T/A - 120/70 mmHg. BNT results - weak positive; by Sudoscan - moderate neuropathy (scores 68 feet/56 hands). Treatment: dietary therapy, physical activity, calcium citrate, vitamins D/B12, multivitamins. Examination results (month 12): HbA1c-5.4%, BMI-26.5kg/m2, T/A -125/70 mmHg; general condition - satisfactory, mood/motivation – high; no PN symptoms; weight loss continued. BNT were near normal; no neuropathy by Sudoscan (scores 75 feet/68 hands). Discussion: The case study shows positive impact of weight loss on glycemia control, ABP and PN. Data of some research indicate positive effect weight loss on diabetic/non-diabetic PN. Further studies are necessary to approve these findings.