Postural Orthostatic Tachycardia Syndrome (POTS), a debilitating autonomic disorder affecting a large number of adolescents (ages 15–25), is characterized by symptoms of autonomic dysregulation. Previous research has indicated the potential benefits of electrocardiography (ECG) biofeedback in mitigating some mental health disorders. Thus, we investigated the impact of ECG biofeedback on POTS, using the EmWave Pro equipment as a method of neurofeedback to modulate POTS symptoms in adolescents. Our study aimed to evaluate the consistency of ECG biofeedback in reducing POTS symptoms in terms of intensity and frequency. This method could potentially lead to a more holistic approach to managing POTS, benefiting both patients and healthcare providers. Twenty young adults diagnosed with POTS participated in our study and were instructed to use the EmWave Pro equipment bi-weekly for a period of four weeks. Participants’ symptoms were assessed at the start and end of the study using a standardized questionnaire. We hypothesized that consistent use of ECG biofeedback would reduce POTS symptoms in terms of intensity, frequency, and impact on daily life. We found that consistent use of ECG biofeedback significantly reduced POTS symptoms. There was a statistically significant decrease in the number and severity of POTS symptoms reported by participants. In conclusion, ECG biofeedback using the EmWave Pro equipment can significantly reduce the intensity and frequency of POTS symptoms in young adults. Further research is needed to investigate the long-term efficacy of ECG biofeedback in managing POTS symptoms, and to explore the underlying mechanisms that mediate this effect.