ObjectiveTo examine the association between elevated maternal postpartum depression symptoms and select targets of nutrition education within the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), including infant feeding beliefs, feeding practices, and dietary intake choices. DesignLongitudinal analysis of secondary data from the WIC Infant and Toddler Feeding Practices Study-2. SettingEighty WIC sites. ParticipantsThe WIC Infant and Toddler Feeding Practices Study-2 participants interviewed through 13 months postpartum (n = 1,851). Main Outcome MeasuresLatent factor variables for infant feeding beliefs, feeding practices, and dietary intake choices. AnalysisConfirmatory factor analysis using structural equation modeling; multivariable linear regression models. ResultsBiological mothers with elevated postpartum depression symptoms engaged in significantly less optimal feeding practices than biological mothers with fewer symptoms of depression, in multivariable analyses controlling for sociodemographic variables (β = −0.26; P = 0.02). Maternal depression symptoms were not significantly associated with infant feeding beliefs or dietary intake choices. Conclusions and ImplicationsMaternal depression symptoms are specifically associated with infant feeding practices. The Special Supplemental Nutrition Program for Women, Infants, and Children could consider screening for depressive symptoms and referring mothers for treatment. For mothers with elevated depression symptoms, nutrition education may need greater emphasis on healthy and safe feeding practices.