Background: Simple cysts are the most common lesions in the kidney and symptomatic patients require treatment. This study evaluates the use of single-sitting percutaneous sclerotherapy with needle aspiration under ultrasound (US) guidance in patients suffering from symptomatic simple renal cysts. Materials and Methods: Twenty-four patients suffering from symptomatic simple renal cysts during the period January 2018 to January 2020 underwent needle aspiration followed by sclerotherapy under ultrasound (US) guidance. Sclerotherapy with 30 mg sodium tetradecyl sulfate (STDS) was performed after aspiration of the renal cysts. A total of 28 symptomatic simple renal cysts in 22 patients were included in the study, two patients were lost for follow-up. The follow-up period was 48 months. Results: The diameter of the renal cysts ranged between 5.5 and 8.5 cm (mean: 6.24 ± 1.05 cm), and between 0 and 4 cm (mean: 0.286 ± 0.004 cm) before and after sclerotherapy, respectively (P < 0.001). The average diameter reduction was 92.16% during the follow-up period of 48 months. Flank pain was resolved in all the patients (100%). The procedure was termed “success” with all the patients. The three cysts in which, the reduction of size was <75% were more than 8 cm in initial size, and in one case, it was bilateral renal cysts. In these cases also, the pain was reduced completely and did not require any further treatment. We did not observe any procedure-related complications. Conclusion: Single-sitting needle aspiration with sclerotherapy using STDS under US guidance is an effective and safe method for treating symptomatic simple renal cysts.
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