The M INIMUM 2SAT-D ELETION problem is to delete the minimum number of clauses in a 2SAT instance to make it satisfiable. It is one of the prototypes in the approximability hierarchy of minimization problems Khanna et al. [Constraint satisfaction: the approximability of minimization problems, Proceedings of the 12th Annual IEEE Conference on Computational Complexity, Ulm, Germany, 24–27 June, 1997, pp. 282–296], and its approximability is largely open. We prove a lower approximation bound of 8 5 - 15 ≈ 2.88854 , improving the previous bound of 10 5 - 21 ≈ 1.36067 by Dinur and Safra [The importance of being biased, Proceedings of the 34th Annual ACM Symposium on Theory of Computing (STOC), May 2002, pp. 33–42, also ECCC Report TR01-104, 2001]. For highly restricted instances with exactly four occurrences of every variable we provide a lower bound of 3 2 . Both inapproximability results apply to instances with no mixed clauses (the literals in every clause are both either negated, or unnegated). We further prove that any k-approximation algorithm for the M INIMUM 2SAT-D ELETION problem polynomially reduces to a ( 2 - 2 / ( k + 1 ) ) -approximation algorithm for the M INIMUM V ERTEX C OVER problem. One ingredient of these improvements is our proof that the M INIMUM V ERTEX C OVER problem is hardest to approximate on graphs with perfect matching. More precisely, the problem to design a ρ -approximation algorithm for the M INIMUM V ERTEX C OVER on general graphs polynomially reduces to the same problem on graphs with perfect matching. This improves also on the results by Chen and Kanj [On approximating minimum vertex cover for graphs with perfect matching, Proceedings of the 11st ISAAC, Taipei, Taiwan, Lecture Notes in Computer Science, vol. 1969, Springer, Berlin, 2000, pp. 132–143].