This paper is concerned with the multiplicity of radially symmetric positive solutions of the Dirichlet boundary value problem for the following N-dimensional p-harmonic equation of the form Δ ( | Δ u | p − 2 Δ u ) =λg(x)f(u),x∈ B 1 , where B 1 is a unit ball in R N (N≥3). We apply the fixed point index theory and the upper and lower solutions method to investigate the multiplicity of radially symmetric positive solutions. We find that there exists a threshold λ ∗ <+∞ such that if λ> λ ∗ , the problem has no radially symmetric positive solution; while if 0<λ≤ λ ∗ , the problem admits at least one radially symmetric positive solution. Especially, there exist at least two radially symmetric positive solutions for 0<λ< λ ∗ .