In the context of the global energy transition, optimizing deep-water oil and gas drilling parameters is crucial for ensuring safety while improving efficiency. Traditional methods face limitations in highly dynamic and nonlinear drilling environments, struggling to balance speed and cost-effectiveness. Furthermore, these methods rely on real-time logging-while-drilling (LWD) data for decision-making, but delays in data collection and processing hinder timely adjustments of drilling parameters, affecting decision accuracy and responsiveness. This paper proposes a multi-objective drilling parameter optimization framework, incorporating symbolic regression, time-series networks, and Markov decision processes to precisely predict ROP, formation conditions, and optimize drilling parameters in real time. Key innovations include a multi-population evolutionary symbolic regression algorithm for constructing empirical equations, the integration of variational mode decomposition (VMD) and sample entropy for data preprocessing, and multi-head self-attention time-series networks to enhance prediction accuracy. Quantile regression further estimates the range of drilling parameter adjustments. Additionally, a drilling parameter optimization deep deterministic policy gradient (DPODDPG) algorithm was developed to automate real-time parameter adjustments. Empirical analysis on the Ledong 10-1 block in the South China Sea demonstrated significant improvements: ROP increased from 54.18 m/hr to 122.17 m/hr, mechanical specific energy (MSE) decreased from 100.82 MPa to 97.78 MPa, and cost per foot reduced from 121.16 × 102 CNY/m to 51.31 × 102 CNY/m. Compared to traditional methods, the proposed framework showed clear advantages in enhancing ROP, reducing MSE, and controlling costs, further validating its superiority in complex drilling environments. This method not only significantly improves drilling efficiency and economic benefits but also adapts to complex and changing drilling conditions, showing broad application potential, particularly in challenging deep-water oil and gas drilling operations, where it can provide more efficient and reliable optimization solutions.