Symbiotic Research Articles

The commercialisation of NTFPs and conservation of forest: a systematic review for forestry policy

PurposeThis current review examines the scientific literature report on non-timber forest products (NTFPs) commercialisation and forest conservation in different jurisdictions.Design/methodology/approachA systematic review using Scopus-indexed articles on NTFP commercialisation and forest conservation was done using the PRISMA framework.FindingsThe review categorised the factors influencing the commercialisation of NTFPs and forest conservation into five broad factors and sub-factors: socioeconomic, market-based, ecosystem, cultural and institutional factors. The scholarly publications on NTFP commercialisation and forest conservation have been undulating, with two years recording no publication on the subject matter under review. Besides, China and India in Asia are leading in the number of publications on NTFPs’ commercialisation. The review revealed ambivalence and symbiotic relationship among the factors influencing the commercialisation of NTFPs and forest conservation. Specifically, tenure arrangement, strict regulations to forest entry, market information asymmetry, bureaucracy in certification acquisition, seasonality and distance were identified as barriers to NTFPs’ commercialisation. While market demands for NTFPs increased, NTFPs’ prices and unsustainable harvesting activities were threats to forest conservation. Policymakers should focus on safeguarding customary property rights and indigenous knowledge in forest conservation, designing workable capacity-building schemes for NTFP entrepreneurs and reducing the cost and processes in certification acquisition.Originality/valueThere are reviews on NTFPs’ commercialisation and livelihoods, but a synergy between NTFPs’ commercialisation and forest conservation for forest policy direction is yet to be done in the literature. Also, while earlier studies systematically reviewed literature on NTFPs’ commercialisation, they did not relate the studies to forest conservation.

Oral Microbiota and the Risk of Gastrointestinal Cancers-A Narrative Literature Review.

The human body is colonized by trillions of microorganisms in a symbiotic relationship. The oral cavity represents one of the most abundant microbial habitats in our body. Advances in sequencing techniques provide a more detailed understanding of the oral microbiota and how imbalances between bacteria, the phenomenon of dysbiosis, can affect not only the development of dental caries or inflammation within the oral cavity but also systemic diseases and cancers in distant locations. This narrative review evaluates the relationship between oral microbiota and its impact on gastrointestinal cancers. Using the keywords "oral microbiota 'AND' gastrointestinal cancers", the PubMed Web of Science and Scopus databases were searched for articles published between 2014 and 2024. Based on the review, the relationship between oral microbiota and oral, esophageal, gastric, colorectal, hepatocellular, and pancreatic cancers was described. Potential oncogenic mechanisms exploited by the microbiota such as the production of pro-inflammatory cytokines, induction of abnormal immune responses, and disruption of cell metabolic pathways were assessed. Further research and a thorough understanding of the impact of the oral microbiota on the development of cancers of the gastrointestinal tract may play a key role in their prevention, diagnosis, and treatment in the future.

How does interprofessional education affect attitudes towards interprofessional collaboration? A rapid realist synthesis.

Interprofessional collaboration (IPC) in healthcare is regarded as important by professionals, as it increases the quality of care while decreasing costs. Interprofessional education (IPE) is a prerequisite for IPC and influences learners' attitudes, knowledge, and collaboration skills. Since attitudes shape behavior, understanding how they are formed is crucial for influencing IPC in learners' professional practice. We investigated what kind of IPE works, for which students, how, and in what circumstances to develop positive attitudes towards IPC. Using realist synthesis, we extracted causal mechanisms that produce positive attitude outcomes and the conducive contexts that trigger them. Our analysis resulted in six plausible context-mechanism-outcome configurations that explain positive attitude development. Positive IPC attitudes are more likely to arise in contexts where IPE provides time and facilities for formal and informal interactions, as this allows learners to get to know each other both professionally and personally, fostering trust, respect, and mutual liking. Additionally, positive attitudes are more likely in contexts where the IPE curriculum is perceived as career-relevant and boosts confidence. Key mechanisms of positive attitude development include getting to know the other learners professionally and personally, experiencing positive affect during IPE, and learners experiencing mutual dependence. Sustained positive attitudes are more likely to develop when there is organizational support for IPC and professionals attend IPE on an ongoing basis, allowing the attitudes and values expected in IPC to be positively reinforced and eventually integrated into the learners' personal value system.

Strategic sourcing decisions: A Swiss bank responding to the dynamics of the core banking system market

This case examines strategic challenges encountered by Berner Kantonalbank (BEKB), a prominent regional Swiss bank. The bank adapts its sourcing decisions related to its core banking system amidst the evolving landscape of the core banking software market. The narrative unfolds against unfulfilled strategic goals in a changing IT industry, revealing the complexities and decisions that shape BEKB’s approach to core banking system sourcing. In 2010, BEKB outsourced its core banking solution to Hewlett Packard (HP). This encompassed the transfer of all employees of its former subsidiary, RTC. RTC had formerly developed and operated BEKB’s core banking solution. The strategic move to outsource aimed to leverage HP’s capabilities for cost-effective core banking system operations. BEKB anticipated enhanced core banking system capabilities at a reduced cost, while HP sought to establish itself in the core banking software market. However, instead of expanding BEKB’s core banking system customer base, clients increasingly migrated to other providers. The evolving circumstances placed BEKB and HP in a mutual dependency, reaching a critical juncture when the bank decided to terminate the contract, which yielded a spectrum of strategic options. The decision taken endured for a few years. Subsequently, another strategic reevaluation was necessary. This case delves into the intricate interplay between sourcing decision and IT software product dynamics, offering perspectives from client and vendor. It sheds fresh light on strategic sourcing decision-making within the evolving landscape of an increasingly complex IT services environment.

Harmonizing Urban Futures: Integrating Smart and Sustainable City Principles

In an era marked by rapid urbanization and evolving urban challenges, understanding the intricate relationship between sustainable and smart city principles is paramount for shaping resilient and future- ready cities. This study delves into the integration of sustainable and smart city principles, aiming to illuminate their interconnectedness in contemporary urban contexts. By analyzing the latest academic understanding of this integration, the research contributes to the development of comprehensive frameworks guiding urban development strategies. Through bibliometric analysis using VOSviewer, key factors such as air quality, intelligent transportation systems, internet connectivity, urban growth, solar energy, and learning processes emerge as central to understanding the interplay between smart and sustainable cities. This analysis informs efforts towards integrated urban development and resilience. The study hypothesizes that smart city principles build upon sustainable city foundations, as evidenced by interrelated indicators across urban domains. Recognizing the significance of this integration, urban planners and policymakers can craft strategies that prioritize sustainability, innovation, and inclusivity, thus shaping resilient and future-ready cities. By elucidating the symbiotic relationship between smart and sustainable city concepts, this research offers insights crucial for addressing contemporary urban challenges and fostering sustainable urban development globally.

Root exudates facilitate the regulation of soil microbial community function in the genus Haloxylon.

Root exudates act as the "language" of plant-soil communication, facilitating crucial interactions, information exchange, and energy transfer between plants and soil. The interactions facilitated by root exudates between plants and microorganisms in the rhizosphere are crucial for nutrient uptake and stress resilience in plants. However, the mechanism underlying the interaction between root exudates and rhizosphere microorganisms in desert plants under drought conditions remains unclear, especially among closely related species. To reveal the ecological strategies employed by the genus Haloxylon in different habitats. Using DNA extraction and sequencing and UPLC-Q-Tof/MS methods, we studied root exudates and soil microorganisms from two closely related species, Haloxylon ammodendron (HA) and Haloxylon persicum (HP), to assess differences in their root exudates, soil microbial composition, and interactions. Significant differences were found in soil properties and root traits between the two species, among which soil water content (SWC) and soil organic carbon (SOC) in rhizosphere and bulk soils (P < 0.05). While the metabolite classification of root exudates was similar, their components varied, with terpenoids being the main differential metabolites. Soil microbial structure and diversity also exhibited significant differences, with distinct key species in the network and differential functional processes mainly related to nitrogen and carbon cycles. Strong correlations were observed between root exudate-mediated root traits, soil microorganisms, and soil properties, although the complex interactions differed between the two closely relative species. The primary metabolites found in the network of HA include sugars and fatty acids, while HP relies on secondary metabolites, steroids and terpenoids. These findings suggest that root exudates are key in shaping rhizosphere microbial communities, increasing microbial functionality, fostering symbiotic relationships with hosts, and bolstering the resilience of plants to environmental stress.

Phytobiomes: Harnessing the Power of Microbial Communities for Plant Health

Phytobiomes encompass the dynamic ecosystems surrounding plants, which include a diverse range of microbial communities such as fungi, bacteria, algae, viruses, and nematodes. These microorganisms interact intricately with plants, influencing their health, growth, and resilience. Beneficial fungi form symbiotic relationships with plant roots, enhancing nutrient absorption, while bacteria play a role in nitrogen fixation and disease suppression. Algae contribute to soil health and organic matter decomposition, and viruses, though often seen as harmful, can provide resistance to certain pathogens. Nematodes, both beneficial and parasitic, regulate soil nutrient cycles and influence plant growth. Harnessing the potential of these microbial communities offers promising solutions for sustainable agriculture. By promoting beneficial interactions within the phytobiome, it is possible to improve plant productivity, enhance nutrient use efficiency, and increase tolerance to environmental stresses such as drought, salinity, and pathogens. Phytobiome research aims to uncover the complex relationships within these microbial networks to develop novel agricultural practices that reduce reliance on chemical inputs. This holistic approach not only promotes plant health but also ensures ecological balance, contributing to the long-term sustainability of agroecosystems in the face of environmental challenges. Understanding the power of microbial communities within phytobiomes is key to advancing future agricultural innovations.

Flags, Verdicts and Texts: Dissident Narratives and Literary Mandates for Re-Writing Empire

Researchers theorising the intersection and intertextuality between literature and law have explored and analysed democracy, governance, and trust from diverse analytical approaches. Political and legal structures are undergoing polycrises and governance is assailed by wicked policy problems, while democratic norms and legitimacy are eroded. Trust—in all its elasticity—is increasingly polarised among groups and linked to ethnic, cultural, and place-based identities and resentments. Past and present experiences in the lace of memory show that racial categories have persisted into the postcolonial chronos, and we need to question what this means for the rhizome of democracy. New ideas and identities challenge how democracy can represent diverse groups and interests, emphasising the nourishing and symbiotic relationships between literature and law within the context of decolonising notions of global-glocal knowledge economies. Governance and legal architecture are held hostage by powerful interest groups, and axiomatic aspirations to kairos and trust in the fair distribution of wealth and resources for the institutionalisation of democracy have been enfeebled. New forms of democratic participation are emerging which challenge the concepts and premises of choice and plurality. Repeated pressures to understand major crises such as criminal and gendered violence where geopolitical instabilities weaken trust in the capacity of democratic processes have not provided acceptable and socially just verdicts. If external pressures on democratic institutions are growing, criticisms against forms of poor governance (e.g., corruption, presidential personalisation of the state, short-termism, polarisation) are also increasingly made against legal and political institutions. New expressions of distrust in flags and resistance against legal, cultural, and economic powers are immanent in literary texts. This article uses Native Son, Mating Birds, and The Trial of Dedan Kimathi to address the following question: What are the pre-requisites and co-requisites for democracy and socially just governance to flourish in legal and literary situations of heightened economic marginalisation, extreme cultural oppressions, and diminishing political legitimacy? The nexus and intersectionality between legal and literary textual structures allow for an analysis of the role and impact of social, cultural, political, and juridical reformulations in the three selected texts. I argue that the (counter)story, as interdisciplinary method, is thus tasked (and suffused) with immense possibilities.

How preferences enslave attention: calling into question the endogenous/exogenous dichotomy from an active inference perspective

AbstractIt is easy to think of attention as a purely sensorimotor, exogenous mechanism divorced from the influence of an agent’s preferences and needs. However, according to the active inference framework, such a strict reduction cannot be straightforwardly invoked, since all cognitive and behavioural processes can at least be described as maximising the evidence for a generative model entailed by the ongoing existence of that agent; that is, the minimisation of variational free energy. As such, active inference models could cast an (embodied) cognitive mechanism like attention, described in this paper as a relevance filter, as constrained (or enslaved) by these prior preferences for which an agent must seek evidence, whether or not such priors are having direct, real-time neurocognitive effects on the sensorimotor loops that couple the attending agent and her surrounding environment. This duality with respect to the role of priors corresponds to a wider, ongoing debate in the active inference community regarding the framework’s explanatory power. More specifically, the debate centres on whether the notion of a generative model and the priors embedded ubiqitously therein act as a purely useful instrumental tool for scientists aiming to model the behaviours of self-organising entities, or, rather, the brain (and body) is genuinely constituted by a predictive hierarchy within which higher-order dynamics constrain and contextualise activity unfolding at lower levels. With a focus on the second (ontologically realist) construal of active inference presented here, this paper argues that in cognitive systems endowed with attentional schema, higher-order preferences do, indeed, impose a demonstrable and powerful modulating effect on the way attention unfolds. Furthermore, these preferences in question transcend the contingent, task-relevant goals that have already been shown to bias attention. Rather, attention is powerfully tuned by the most-deep rooted priors the agent possesses, such that, when sensory evidence against these priors is observed and free energy spikes, the agent attentionally prioritises the homeostatic restoration of these preferred states over their shorter-term desires. This suggests that, at its core, attention is a goal-driven process, which calls into question the putative dichotomy that exists between endogenous (goal-directed) attention and exogenous (stimulus-driven) attention. What emerges in its place is a symbiotic relationship between attention and preferences, whereby the fulfilment of the latter rests on successful application of the former, and the former derives its function from the organismic need to find evidence for the latter.

Probiotics as a potential tool for gynecological cancers prevention and therapy suport

The human body is host to a variety of microbial species that are essential for maintaining general health. About nine percent of these microbial species inhabit the urogenital tract. It is therefore important to establish a symbiotic relationship between the host’s immune system and the microbiota in this region. Disruptions of this symbiosis can contribute to the development of pelvic inflammatory disease (PID), bacterial vaginosis (BV), vaginal candidiasis and/or even gynaecological cancers by promoting the proliferation of infectious agents. The chemotherapeutic agents currently used in cancer treatment are associated with undesirable side effects. Therefore, there is an urgent need for antitumor agents that have minimal toxicity compared to conventional treatments. Furthermore, the use of drugs to prevent or alleviate the side effects of cervical cancer treatment could significantly improve the quality of life of patients undergoing such therapy. In this review, we focus our attention on the potential efficacy of probiotics in both the prevention and therapeutic intervention of neoplasms affecting the genital tract.

Lipid-Laden Macrophages Recycle Myelin to Feed Glioblastoma.

Tumor-associated microglia and macrophages (TAM) make up the largest immune cell population in the glioblastoma (GBM) tumor microenvironment. Given the heterogeneity and plasticity of TAMs in the GBM tumor microenvironment, understanding the context-dependent cancer cell-TAM symbiotic interaction is crucial for understanding GBM biology and developing effective therapies. In a recent issue of Cell, Kloosterman and colleagues identified a subpopulation of glycoprotein nonmetastatic melanoma protein Bhigh lipid-laden microglia and macrophages (LLM) in GBM. Mesenchymal-like GBM cells help generate the LLM phenotype. Reciprocally, LLMs are epigenetically rewired to recycle myelin and transfer the lipid from myelin to cancer cells, fueling mesenchymal-like GBM progression in a liver X receptor/ABCA1-dependent manner. Together, leveraging LLMs opens new therapeutic possibilities for rewiring the metabolism-mediated tumor-TAM interaction during GBM progression.

Frequent and asymmetric cell division in endosymbiotic bacteria of cockroaches.

Many insects are obligatorily associated with and dependent on specific microbial species as essential mutualistic partners. In the host insects, such microbial mutualists are usually maintained in specialized cells or organs, called bacteriocytes or symbiotic organs. Hence, potentially exponential microbial growth cannot be realized but must be strongly constrained by spatial and resource limitations within the host cells or tissues. How such endosymbiotic bacteria grow, divide, and proliferate is important for understanding the interactions and dynamics underpinning intimate host-microbe symbiotic associations. Here we report that Blattabacterium, the ancient and essential endosymbiont of cockroaches, exhibits unexpectedly high rates of cell division (20%-58%) and, in addition, the cell division is asymmetric (average asymmetry index >1.5) when isolated from the German cockroach Blattella germanica. The asymmetric division of endosymbiont cells at high frequencies was observed irrespective of host tissues (fat bodies vs ovaries) or developmental stages (adults vs nymphs vs embryos) of B. germanica, and also observed in several different cockroach species. By contrast, such asymmetric and frequent cell division was observed neither in Buchnera, the obligatory bacterial endosymbiont of aphids, nor in Pantoea, the obligatory bacterial gut symbiont of stinkbugs. Comparative genomics of cell division-related genes uncovered that the Blattabacterium genome lacks the Min system genes that determine the cell division plane, which may be relevant to asymmetric cell division. These observations combined with comparative symbiont genomics provide insight into what processes and regulations may underpin the growth, division, and proliferation of such bacterial mutualists continuously constrained under within-host conditions.IMPORTANCEDiverse insects are dependent on specific bacterial mutualists for their survival and reproduction. Due to the long-lasting coevolutionary history, such symbiotic bacteria tend to exhibit degenerative genomes and suffer uncultivability. Because of their microbiological fastidiousness, the cell division patterns of such uncultivable symbiotic bacteria have been poorly described. Here, using fine microscopic and quantitative morphometric approaches, we report that, although bacterial cell division usually proceeds through symmetric binary fission, Blattabacterium, the ancient and essential endosymbiont of cockroaches, exhibits frequent and asymmetric cell division. Such peculiar cell division patterns were not observed with other uncultivable essential symbiotic bacteria of aphids and stinkbugs. Gene repertoire analysis revealed that the molecular machinery for regulating the bacterial cell division plane are lost in the Blattabacterium genome, suggesting the possibility that the general trend toward the reductive genome evolution of symbiotic bacteria may underpin their bizarre cytological/morphological traits.

The Ecological Strategy Determines the Response of Fungi to Stress: A Study of the 2,4-diacetylphloroglucinol Activity Against Aspergillus and Fusarium Species.

Aspergillus and Fusarium are two economically important genera of fungi. They cause significant yield losses and contamination of crops with mycotoxins. In this study we aimed to evaluate the impact of 2,4-diacetylphloroglucinol (2,4-DAPG) on Aspergillus and Fusarium fungi. It is hypothesized that two fungal genera, which have different ecological strategies, react differently to stress caused by a secondary metabolite produced by rhizosphere Pseudomonas species. We found that 2,4-DAPG was able to reduce biofilm formation of Aspergillus and Fusarium, as reflected in biomass and its chemical composition. Furthermore, subinhibitory concentrations of 2,4-DAPG increased the levels of ergosterol and polysaccharides (α- and β-glucans, chitin) in the cell membrane and cell wall of Aspergillus, while decreasing them in Fusarium. 2,4-DAPG altered the production of secondary metabolites, especially mycotoxins and extracellular proteases. The production of ochratoxin A was decreased in A. ochraceus, and T-2 toxin and zearalenone, on the contrary, were increased in F. culmorum and F. sporotrichioides, respectively. Thus, using 2,4-DAPG we demonstrated that the ecological role of fungi determines their reaction to antibiotic substances produced by the plant microbiome. Our data contributes to understanding the molecular mechanisms behind symbiotic relationships in natural communities, which are mediated by the biosynthesis of antibiotics.

The Biology, Impact, and Management of Xyleborus Beetles: A Comprehensive Review.

Xyleborus beetles, a diverse group of ambrosia beetles, present challenges to forestry and agriculture due to their damaging burrowing behavior and symbiotic relationships with fungi. This review synthesizes current knowledge on the biology, ecology, and management of Xyleborus. We explore the beetles' life cycle, reproductive strategies, habitat preferences, and feeding habits, emphasizing their ecological and economic impacts. Control and management strategies, including preventive measures, chemical and biological control, and integrated pest management (IPM), are critically evaluated. Recent advances in molecular genetics and behavioral studies offer insights into genetic diversity, population structure, and host selection mechanisms. Despite progress, managing Xyleborus effectively remains challenging. This review identifies future research needs and highlights innovative control methods, such as biopesticides and pheromone-based trapping systems.

Histone deacetylase HDAC3 regulates ergosterol production for oxidative stress tolerance in the entomopathogenic and endophytic fungus Metarhizium robertsii.

Oxidative stress is encountered by fungi in almost all niches, resulting in fungal degeneration or even death. Fungal tolerance to oxidative stress has been extensively studied, but the current understanding of the mechanisms regulating oxidative stress tolerance in fungi remains limited. The entomopathogenic and endophytic fungus Metarhizium robertsii encounters oxidative stress when it infects insects and develops a symbiotic relationship with plants, and we found that host reactive oxygen species (ROSs) greatly limited fungal growth in both insects and plants. We identified a histone H3 deacetylase (HDAC3) that catalyzed the deacetylation of lysine 56 of histone H3. Deleting Hdac3 significantly reduced the tolerance of M. robertsii to oxidative stress from insects and plants, thereby decreasing fungal ability to colonize the insect hemocoel and plant roots. HDAC3 achieved this by regulating the expression of three genes in the ergosterol biosynthesis pathway, which includes the lanosterol synthase gene Las1. The deletion of Hdac3 or Las1 reduced the ergosterol content and impaired cell membrane integrity. This resulted in an increase in ROS accumulation in fungal cells that were thus more sensitive to oxidative stress. We further showed that HDAC3 regulated the expression of the three ergosterol biosynthesis genes in an indirect manner. Our work significantly advances insights into the epigenetic regulation of oxidative stress tolerance and the interactions between M. robertsii and its plant and insect hosts.IMPORTANCEOxidative stress is a common challenge encountered by fungi that have evolved sophisticated mechanisms underlying tolerance to this stress. Although fungal tolerance to oxidative stress has been extensively investigated, the current understanding of the mechanisms for fungi to regulate oxidative stress tolerance remains limited. In the model entomopathogenic and plant symbiotic fungus Metarhizium robertsii, we found that the histone H3 deacetylase HDAC3 regulates the production of ergosterol, an essential cell membrane component. This maintains the cell membrane integrity to resist the oxidative stress derived from the insect and plant hosts for successful infection of insects and development of symbiotic associates with plants. Our work provides significant insights into the regulation of oxidative stress tolerance in M. robertsii and its interactions with insects and plants.

Plant probiotic microbes – trending microbes for plant growth and value addition of compost- a review

New agricultural approaches, including natural and organic farming, have developed organic and microbiological goods. Beneficial microbes known as plant probiotic microorganisms (PPM) are primarily found in soil and have coevolved with plants in a symbiotic or free-living relationship. By encouraging plant growth and health, these bacteria lessen the need for artificial fertilizers, support environmentally friendly agricultural practices, and improve plant health. Agroecosystem vigour, biodiversity, biological cycles, and soil biological activity are all enhanced by using plant probiotic bacteria in biologically based agriculture. By using beneficial bacteria to support the health and function of the host organism, plant probiotics aim to lessen the demand for toxic pesticides and fertilizers. Using these probiotic microorganisms will have a synergistic and advantageous effect on crop production. Plant probiotic microorganisms improve the overall quality of compost throughout the composting process by accelerating the breakdown of organic materials and introducing helpful bacteria. This rich compost adds beneficial bacteria to the soil, creating a healthy and productive environment. This review looks at the common plant probiotic bacteria, how they work, how they complement each other to improve compost quality and plant growth, how they might be used in agriculture, and how they could change how composting is done.

Bird’s Eye View of Gut Microbiota: Role In Health And Disease

The human gut hosts several trillion organisms, forming a complex ecosystem. In a state of health, the good microbes contribute to the defense mechanisms and protect the host. Alterations in gut microbiota can lead to metabolic or immune disorders. A symbiotic relationship exists between the host and the gut microbiota. This review defines and details gut microbiota and related terminologies, explores its mechanisms of action, and examines its association with several commonly encountered autoimmune and metabolic disorders, as well as several autoimmune and metabolic disorders. Additionally, it summarizes methods for modulating gut microbiota to treat, reverse, or prevent certain diseases. Emerging technologies for fingerprinting gut microbiota and their potential to introduce new therapeutic modalities are also discussed.

Potential for artificial symbiosis between marine microalgae and invertebrates: I. survival of marine microalgae injected into the medusa of the moon jellyfish Aurelia aurita

Some marine microalgae and cyanobacteria form mutualistic symbioses with diverse invertebrates, particularly cnidarians. Among microalgae, dinoflagellates in the family Symbiodiniaceae are the most well-known symbiotic partners of jellyfish and corals. However, the symbioses involving other dinoflagellate families, nano- and micro-flagellates, diatoms, and cyanobacteria with cnidarians are not well understood. As an initial step, it is essential to explore the survival of these microorganisms inside cnidarians. We monitored the survival of eight microalgal species (nine strains) and one cyanobacterium species every day for seven days after injecting each into the medusa of the moon jellyfish &lt;i&gt;Aurelia aurita&lt;/i&gt;. The dinoflagellates &lt;i&gt;Effrenium voratum&lt;/i&gt; (free-living [FL] and living-in-coral strains), &lt;i&gt;Cladocopium infistulum&lt;/i&gt;, &lt;i&gt;Prorocentrum cordatum&lt;/i&gt;, &lt;i&gt;Prorocentrum koreanum&lt;/i&gt;, &lt;i&gt;Symbiodinium microadriaticum&lt;/i&gt;, the prasinophyte &lt;i&gt;Tetraselmis suecica&lt;/i&gt;, the chlorophyte &lt;i&gt;Dunaliella salina&lt;/i&gt;, and the raphidophyte &lt;i&gt;Heterosigma akashiwo&lt;/i&gt; survived inside the medusa, while the cyanobacterium &lt;i&gt;Synechococcus&lt;/i&gt; sp. was not detected. Additionally, &lt;i&gt;E. voratum&lt;/i&gt; (FL) survived within the medusa for 60 days and gradually spread to adjacent areas, indicating potential for artificially established symbiosis. The results of this study provide a basis for artificial symbiosis between microalgae and invertebrates.

ANALYSIS OF THE IMPACT OF DIGITALIZATION ON THE DEVELOPMENT OF OPPORTUNITIES FOR SMALL AND MEDIUM-SIZED ENTERPRISES

The article analyzes how the use of information and communication technologies and digital marketing tools contribute to increasing competitiveness, optimizing business processes, expanding sales markets, and improving customer relations. This article offers a comprehensive examination of the intricate dynamics between innovation, entrepreneurship, and economic growth, drawing from an extensive review of empirical studies, theoretical frameworks, and policy implications. Through a meticulous analysis of the symbiotic relationship between innovation and entrepreneurship, it elucidates their multifaceted contributions to driving sustained economic prosperity. By delving into the nuanced mechanisms and contextual factors that shape this relationship, the article provides insights for policymakers, researchers, and practitioners seeking to foster innovation-led growth in today's complex global economy. In the context of contemporary economic development, innovation and entrepreneurship have emerged as central pillars driving productivity growth, technological progress, and market dynamism. This paper embarks on a journey to unravel the complex interplay between these two phenomena and how their synergistic relationship shapes the trajectory of economic growth. By examining the underlying mechanisms, empirical evidence, and policy implications, we aim to shed light on the transformative potential of innovation and entrepreneurship in fostering sustainable development and competitiveness. Innovation and entrepreneurship are essential engines of economic growth. Innovation is characterized by the creation and adoption of novel ideas, technologies, and business models, and is a catalyst for entrepreneurial activity by providing opportunities for market differentiation and value creation

435 Use of plant bioactives to improve the efficiency of rumen function

Abstract Plant bioactives, also known as phytogenics or phytobiotics, are secondary metabolites of plant origin that are deployed as host-defense mechanisms against predators or to enable them to be more competitive in their environment. These metabolites also regulate growth and reproductive functions in the plant. They can be grouped into three major classes: terpenoids, phenolic compounds, and alkaloids. Various studies have shown their worth in improving livestock production and health via insectifugal, organoleptic and enhanced rumen functions. Ruminants are critical to food security because they are able to convert poor-quality feed materials into nutritious products like meat. The rumen provides temporary storage of feed but serves the main function of digesting those complex materials through symbiotic relationships among prokaryotic and eukaryotic organisms within the rumen vat. Antimicrobial resistance and other health or social license challenges have led researchers to find acceptable replacements that will not exacerbate the health and social issues in animals and humans. Plant bioactives appeal to producers because of the ‘natural’ brand and because they are usually certified as generally recognized as safe (GRAS). Anecdotal reports from input companies show an increased demand for mineral supplements infused with phytogenics. The complex chemical compositions of these products appear to make them less prone to developing resistance by microorganisms. Phytogenics research has been further catalyzed by government legislation that has banned the use of medically important antibiotics to prevent the spread of antibiotic resistance. Potential improvements in livestock productivity are associated with mechanisms such as enhanced nutrient utilization, increased digestibility, modified digestive secretions or altered microbial communities. These benefits contribute to the increasing use of these phytogenics by livestock producers to keep their animals healthy and productive while enhancing the profitability of their operations. We will examine the different bioactives and their applications in improving the efficiency of the rumen function. Some commercial products in the Canadian market will be presented. Other research trials showcasing their potential benefits to rumen health and general animal productivity will also be discussed.