Dichotic listening to verbal stimuli results in a right ear advantage (REA), indicating a left hemisphere processing superiority. The magnitude of the REA can be modulated by instructions to direct attention to the left or right ear stimulus. A previous study from our laboratory showed that presenting a prime syllable before the presentation of the dichotic syllables increases reports of the nonprimed syllable, apparently a negative priming effect that inhibits attention to the distracting prime representation. The present study combined attention instruction and priming, making up a 3 x 3 factorial design. The prime stimulus was a single consonant-vowel syllable presented binaurally just before onset of the dichotic consonant-vowel syllables. Results showed that both instructions and priming manipulations had an effect on which dichotic stimulus was selected. There was also a significant interaction between attention instruction and priming manipulation, indicating that the mechanism for instructed attention and the mechanism for negative priming work on the same level of processing.