Ficus Sycomorus Research Articles

Isolation, characterization and antimicrobial study of lupeol acetate from the root bark of Fig-Mulberry Sycamore (<i>Ficus sycomorus</i> LINN)

The phytochemical investigation of n-butanolic extract from the root bark of Ficus sycomorus using microwave-assisted extraction revealed the presence of steroids, triterpenes, flavonoids, alkaloids, and tannins. Detailed chromatographic techniques on the extract led to the isolation of a triterpenoid compound for the first time from the part of the plant, which was identified as lupeol acetate by chemical and spectroscopic studies. Antimicrobial activity study of the isolated compound on some selected microorganisms showed that the compound is a potential source of antibiotic agents.Keywords: Antimicrobial, Ficus sycomorus, lupeol acetate, root bark

Acute and subacute toxicity study of ethanol extract of <i>Ficus sycomorus</i> L. (Moraceae) leaf and Faidherbia albida (Fabaceae) stem bark

Traditionally in northern Nigeria, different parts of Ficus sycomorus (FS) and Faidherbia albida (FA) plants are commonly used to manage diverse medical ailments including diabetes and epilepsy. This study was undertaken to ascertain the acute and sub-acute toxicity of ethanol extracts of FS leaves and FA stem bark in Wistar albino rats. The fresh leaves of FS and the stem bark of FA were collected, prepared and extracted using 95% ethanol. The subacute toxicity test was carried out using ten groups of five rats each: control group, four doses of ethanol leaf extract of FS, four doses of ethanol stem bark extract of FA and combination of FS and FA extract. The extracts were administered orally on daily basis for 28 days. At the end of the study, all animals were sacrificed at which the blood samples were collected for biochemical and haematological analysis respectively. The results of acute toxicity study showed the extracts were relatively less toxic. Sub-acute administration of the combined extract of FS and FA did not significantly affect haematological, renal and hepatic functions. However, there was a dose dependent decrease in the renal function. Bark extract of FA significantly increased the levels of ASAT, ALAT, TB and CB (p<0.05) at the doses of 250 and 500mg/kg. The combined extract of FS and FA was found to be relatively safe on hematological parameters and did not alter the hepatic and renal functions. Thus, justifies the traditional use of these plants combination for managing diseases in northern Nigeria.Keywords: Ficus sycomorus; Faidherbia albida; Ethanol extract; Acute toxicity; Sub-acute toxicity

TLC separation and antioxidant activity of flavonoids from Carissa bispinosa, Ficus sycomorus, and Grewia bicolar fruits

BackgroundCarissa bispinosa, Ficus sycomorus, and Grewia bicolar are edible fruit plants that grow in the wild. The plants produce yellow-, red-, and purple-colored fruits and thus can be good sources of flavonoids for fighting oxidative reactions in humans, food, and the pharmaceutical industry. The present study aimed at isolating flavonoids from C. bispinosa, F. sycomorus, and G. bicolar fruits and determining their antioxidant activity using the 2, 2-diphenyl-1- picrylhydrazyl (DPPH) and 2, 2-azino-bis 3-ethylbenz-thiaz-oline-6-sulfonic acid (ABTS) model radical assays.MethodsAnalytical and preparative thin-layer chromatography was used to isolate flavonoids from the fruits using methanol/chloroform/hexane (7:2:1, v/v/v) as a mobile phase system. The ABTS and DPPH radical scavenging methods were used to test for the antioxidant activity of the samples, using quercetin and catechin as reference standards.ResultsThin-layer chromatographic profiling revealed two different types of flavonoids from each plant. C. bispinosa yielded two flavonoid bands, Rf values 0.11 and 0.38; G. bicolar yielded two flavonoid bands, Rf values 0.63 and 0.81; and F. sycomorus also yielded two types of flavonoids, Rf values 0.094 and 0.81. All the extracted flavonoids exhibited significant antioxidant activity of over 80% at a concentration of 200 mg/L. The order of radical scavenging activity for the 200-mg/L samples is G. bicolar Rf (0.81) > C. bispinosa Rf (0.113) > F. sycomorus Rf (0.094) > F. sycomorus Rf (0.047) > C. bispinosa Rf (0.38) > G. bicolar Rf (0.63). G. bicolar (Rf = 0.81) exhibited antioxidant activity that was superior to that of catechin.ConclusionThe present study results show that C. bispinosa, F. sycomorus, and G. bicolar contain different flavonoid types with significant antioxidant activity of over 80% at a concentration of 200 mg/L. Therefore, the fruits can be used as a source of natural antioxidants which can be used as nutraceuticals to promote health, as preservatives to delay peroxidation of foods, and as flavoring for packed foods.

Ethnobotanical Survey and Biological Activities of Two Lactogenic Plants in the Cascades Region of Burkina Faso

An ethnobotanical survey for a better knowledge of lactogenic plants has been conducted in Cascades region of Burkina Faso. Biological activities of the two most used plants were evaluated. The survey concerned 25 species classified into 22 genera and 19 families. The most represented families were Moraceae, Apocynaceae, Fabaceae-Caesalpinioideae and Malvaceae. The most used species were Euphorbia hirta, Calotropis procera and Ficus sycomorus with respectively 16.98%, 13.21% and 13.21% followed by Ficus platyphylla (9.43%) and Carica papaya, Holarrhena floribunda, Scoparia dulcis, Sorghum bicolor, each with 3.77% of frequency use. Plants organs mostly used for medicinal preparation were leaves, whole plant for herbaceous species, fruits and seeds. The main mode of medicinal preparation was decoction with 60.42% of frequency use. The most route of administration was oral (68.75%). Biological activities evaluation concerned Euphorbia hirta and Calotropis procera which were the most used plants. The acute toxicity of aqueous extracts of Calotropis procera (AECP) and Euphorbia hirta (AEEH) showed a LD50 of 2063 and 603 mg/kg body weight (b.w), respectively. These LD50 values permitted to classify these plants as slightly toxic herbal drugs. The uterotrophic test showed that the AECP and AEEH exhibited estrogenic activity. In conclusion, important medicinal plants in the Cascades region of Burkina Faso were used to stimulate or ameliorate lactation. However further studies must be conducted to confirm the traditional use of these plants.

Ficus sycomorus extract reversed behavioral impairment and brain oxidative stress induced by unpredictable chronic mild stress in rats

BackgroundStress, regardless of its nature is nowadays recognized as one of the major risk factors for neuropsychiatric diseases, such as mood and anxiety disorders. The brain compared with other organs is more vulnerable to oxidative damage mainly due to its high rate of oxygen consumption, abundant lipid content, and relative insufficiency of antioxidant enzymes. Thus, the identification of neural mechanisms underlying resistance and vulnerability to stress is of crucial importance in understanding the pathophysiology of neuropsychiatric disorders and in developing new treatments, since the existing ones are for several reasons subject to increasing limitations. This study was aimed to assess the effects of hydromethanolic extract of Ficus sycomorus stem bark on depression, anxiety and memory impairment induced by unpredictable chronic mild stress (UCMS) in rats.MethodsThese effects were studied using anxiety-related behavior, depression-related behavior, anhedonia-like behavior and the Y maze task. Sucrose test was performed twice (before and after UCMS) to assess anhedonia in rats. Liquid chromatography-mass spectrometry analysis of the extract were performed. The antioxidant activities of the extract were assessed using total glutathione (GSH) content and malondialdehyde (MDA) level (lipid peroxidation) in the rat temporal lobe homogenates.ResultsThe extract of F. sycomorus in a dose of 100 mg/kg significantly increased the sucrose consumption and the swimming time which had been reduced by the unpredictable chronic mild stress (p < 0.001). The extract also significantly reduced (p < 0.01) the latency time in the novelty-suppressed feeding test. In the elevated plus-maze, the extract (100 and 200 mg/kg) significantly reduced (p < 0.01) the time and the number of entries into the closed arms. The treatment with the extracts also significantly increased alternation in the Y-maze (p < 0.01 for 100 mg/kg). The extract significantly increased the total GSH content and reduced MDA level in rat temporal lobe. For the LC–MS analysis, the major compound in the extract was a flavonoid with formula C22H28O14.ConclusionsF. sycomorus reversed the harmful effects of UCMS on mood and behaviors in rats and it possesses an antidepressant property that is at least in part mediated through the oxidative pathway.

Investigation of the acaricidal activity of the acetone and ethanol extracts of 12 South African plants against the adult ticks of Rhipicephalus turanicus.

The acaricidal activity of acetone and ethanol extracts of 12 plant species was evaluated using the contact method on Rhipicephalus turanicus (Acari: Ixodidae) ticks at an initial concentration of 20% (200 mg/mL). Eight of the 12 plants had mortality greater than 50% and the acetone extracts had better acaricidal activity than the ethanol extracts. The acetone extract of Calpurnia aurea (leaves and flowers) had the highest corrected mortality (CM) of 92.2% followed by Schkuhria pinnata (whole plant) with a CM of 88.9%, Ficus sycomorus (bark and stems) 86.7% and Senna italica subsp. arachoides (roots, leaves and fruits) 83.3%. Selected extracts were tested at five different concentrations using the adult immersion test. From dose–response assays, EC50 values of 61.82 mg/mL, 115.21 mg/mL and 161.02 mg/mL were obtained for the acetone extracts of S. pinnata (whole plant), S. italica subsp. arachoides (roots, leaves and fruits) and C. aurea (leaves and flowers) respectively. The ethanol extract of Monsonia angustifolia (whole plant) had the highest CM of 97.8% followed by S. pinnata (whole plant) with a CM of 86.7%, C. aurea (leaves and flowers) 81.1% and Cleome gynandra (leaves) 77.8%. There is potential for the development of environmentally benign botanicals as natural acaricides against R. turanicus.

A critical evaluation of the degradation state of dry archaeological wood from Egypt by SEM, ATR-FTIR, wet chemical analysis and Py(HMDS)-GC-MS

An in-depth investigation was undertaken of the chemical changes to wood induced by degrading agents in dry burial environments. The degradation state of eleven wood samples from dry archaeological sites in Egypt was evaluated by combining the information obtained by scanning electron microscopy (SEM), wet chemical analysis (WCA), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and analytical pyrolysis gas chromatography mass spectrometry with in situ silylation (Py(HMDS)-GC-MS). The samples belonged to five different wood species (Faidherbia albida, Ficus sycomorus, Taxus baccata, Pinus sylvestris and Tamarix sp.) and came from three different archaeological sites corresponding to three different time periods (from ca. 1700 BC to ca. 1700 AD). The results were compared with sound reference wood of the same species.SEM enabled a fungal attack to be identified in some of the samples. WCA highlighted the preferential loss of lignin or carbohydrates in these samples, but also showed unusually high values of water-soluble substances in most of them. FTIR spectra acquired before and after the extraction of the samples revealed that this soluble fraction generally contained depolymerised carbohydrates and/or lignin units. Py(HMDS)-GC-MS was applied without any sample pre-treatment and was used to assess the alteration/depolymerisation of the individual wood components, thus complementing the picture regarding the chemical changes.The results showed that, unlike waterlogged archaeological wood, most of the degraded wood components – depolymerised carbohydrates and/or lignin – had not leached away from the dry wood matrix, and thus complicated the interpretation of data. The commonly used parameters, such as the H/L (holocellulose/lignin) ratio, failed to give a correct evaluation of the wood degradation when both carbohydrates and lignin were degraded. The preservation conditions of the samples were very variable, from very good to a high depletion of carbohydrates, to the preferential depletion of lignin, or comparable levels of carbohydrate and lignin degradation. This was sometimes observed within the same wood species and the same archaeological site.This highlighted how difficult the interpretation can be in order to correctly evaluate the multiple causes of degradation affecting dry archaeological wood. An analytical approach using complementary techniques appears to be essential.

Egyptian Sarcophagi and Mummies in the San Diego Museum of Man: Some Technical Studies

ABSTRACTNine ancient Egyptian sarcophagi of the twenty-fifth to twenty-sixth dynasty, one Ptolemaic Hawk Mummy, and one Amarna fresco were examined in the collections of the San Diego Museum of Man. Binding media, pigments, wood identification, deterioration and alteration products were identified. The pigment palette represents the basic suite of ancient Egyptian pigments: charcoal black, red ochre, yellow ochre, Egyptian blue, green earth, calcite, and gypsum. In the case of the Hawk mummy, oxammite was identified as a degradation product, together with magnesium phosphate, the first identification of oxammite in ancient artefacts. In a child’s coffin, realgar and orpiment were additionally identified. The binding media for practically all of the coffins studied was confirmed as gum Arabic with only one example of gum tragacanth found from a wall plaque from Amarna. Wood identification showed that Ficus sycomorus had been used, rather than the assumed cedar of Lebanon for coffin manufacture. One unidentified species of shrubby wood was also found. Some of the coffins had been restored, with one having a completely repainted face, in rutile, and the child’s coffin has an attached foot-box with modern screws. Possible indications of ancient reuse were found during the study.

Typification of the name of the Afrotropical sycomore fig Ficus sycomorus (Moraceae), and nomenclatural remarks on its synonyms

AbstractThe typification of the name of the Linnaean sycomore fig Ficus sycomorus subsp. sycomorus (Moraceae) is discussed. The name is lectotypified using an original illustration from Mattioli’s De plantis epitome utilissima, and an epitype is also selected. The types of the name F. sycomorus subsp. gnaphalocarpa and several synonyms are nomenclaturally revised.

Characterization of Ficus sycomorus tannin using ATR-FT MIR, MALDI-TOF MS and 13C NMR methods

The Ficus sycomorus bark tannin was extracted and characterized using Attenuated Total Reflectance Fourier Transform Middle Infrared (ATR-FT MIR) spectra in the 1800 and 600 cm−1 range, Matrix Assisted Laser Desorption Ionisation Time of Flight Mass Spectrometry (MALDI-TOF MS) and Carbon-13 Nuclear Magnetic Resonance (13C NMR) spectroscopy methods. Ficus sycomorus species have a very high percentage (46%) yield of tannin. These three characterization methods have shown that the Ficus sycomorus bark tannin is condensed and particularly a procyanidin type. It is composed of quercetin, apigenin, fisetinidin, catechin, gallocatechin, chalcone, radicinin, catechin gallate units with the presence of carbohydrates, quinone and gallic acid residues. The analysis results revealed that quercetin are the major constituents of Ficus sycomorus bark tannin. This procyanidin type tannin can give good wood adhesives.

Corrosion Inhibition of Mild Steel and Aluminium in 1 M Hydrochloric Acid by Leaves Extracts of Ficus sycomorus

Corrosion Inhibition of Mild Steel and Aluminium in 1 M Hydrochloric Acid by Leaves Extracts of Ficus sycomorus

Taxonomic revision and molecular phylogenetics of the Idarnes incertus species-group (Hymenoptera, Agaonidae, Sycophaginae).

Sycophaginae is a group of non-pollinating fig wasps considered closely related to the fig pollinators (Agaoninae, Tetrapusiinae, and Kradibiinae) in the most recent phylogenetic analyses. They occur in all tropical regions and are associated with Ficus subgenera Urostigma and Sycomorus. There are six described genera of Sycophaginae, and two are native and confined to the Neotropics, namely Idarnes Walker, 1843 and Anidarnes Bouček, 1993. Genus Idarnes is divided into three morphologically distinct groups that were proven to be monophyletic by recent molecular phylogenetic analyses. In this paper we reviewed the Idarnes incertus species-group and provide detailed morphological descriptions and illustrations for the species belonging to this group. Three previously described species were redescribed: I. brasiliensis (Mayr, 1906) comb. nov., I. hansoni Bouček, 1993, and I. incertus (Ashmead, 1900). Seventeen new species are described by Farache and Rasplus: I. amacayacuensis sp. n., I. amazonicus sp. n., I. americanae sp. n., I. badiovertex sp. n., I. brevis sp. n., I. brunneus sp. n., I. comptoni sp. n., I. cremersiae sp. n., I. dimorphicus sp. n., I. flavicrus sp. n., I. flaviventris sp. n., I. gibberosus sp. n., I. gordhi sp. n., I. maximus sp. n., I. nigriventris sp. n., I. pseudoflavus sp. n. and I. ramirezi sp. n. We provided keys for the identification of the species as well as for recognising the different species-groups of Idarnes and a closely related genus (Sycophaga Westwood, 1840). Additionally, phylogenetic relationships among 13 species of the I. incertus species-group were inferred using four molecular markers and discussed in the light of Ficus taxonomy and host specificity.

Anticonvulsant activity of the methanol root bark extract of Ficus sycomorus Linn. (Moraceae)

Context: Ficus sycomorus Linn. (Moraceae) is used in Northern Nigeria for the management of grand mal epilepsy without any scientific validation. Aims: To evaluate the phytochemical constituents, acute toxicity study and anticonvulsant properties of the methanol root bark extract of F. sycomorus. Methods: The basic phytochemical screening, Lorke’s method and three models of epilepsy were employed, which include the maximal electroshock test in chicks, and pentylenetetrazole- and 4-aminopyridine-induced seizures in mice. Results: The extract revealed the presence of tannins, saponins, carbohydrate, alkaloids, flavonoids, steroids, terpenoids and cardiac glycosides. The intraperitoneal LD50 in mice was estimated to be 565.69 mg/kg body weight. The extract afforded a slight protection, 30% (highest dose used) to the laboratory animals against the maximal electroshock test. The duration of convulsion decreased, which was not statistically significant (p&gt;0.05) when compared to the untreated group. Also, the extract did not protect the animals against the chemically induced seizures by pentylenetetrazole and 4-aminopyridine. Conclusions: The data suggest that the methanol root bark extract of F. sycomorus, at the doses tested and under the experimental conditions reported, may not contain psychoactive principles that are relevant to the management of grand mal epilepsy as claimed by the traditional medicine practitioners.

Assessing composition and diversity of woody vegetation in mined arid and semi arid lands of Kerio valley, Kenya

The woody vegetation in semi-arid area is important in providing ecosystem services and goods. However, it faces threats manifested in land-use changes such as mining. This study aimed at assessing the composition and diversity of woody vegetation as well as inherent soil physico-chemical parameters in a previously mined area and comparing it with a semi-pristine adjacent area. Six transects containing five plots each were established within two blocks separated by a river. In each plot, data was collected on woody tree growth characteristics and soil parameters. Thirteen woody species were recorded in the rehabilitated mined and twenty two in semi-pristine sites with Ficus sycomorus L Moraceae being the dominant species at the two sites. Woody vegetation diversity was higher in semi-pristine site than in the rehabilitated mined site. However, this was not significant (t-test, =D.F=1 P=0.767). Mean soil nutrients (F2, 7. = P=0.821), pH (F2, 7. =109.88, P=xxx), was higher in rehabilitated mined sites while mean soil temperature (F2, 7. =9.08, P=0.011) was higher in mined areas. Rehabilitating mined sites can bring back species diversity, composition, however what is not clear is whether ecosystem functions are restored.Â

Hooded Vulture Necrosyrtes monachus and African White-backed Vulture Gyps africanus nesting at the Olifants River Private Nature Reserve, Limpopo province, South Africa

Basic ecological information is still lacking for many species of African vultures. The Hooded Vulture Necrosyrtes monachus is known as a rare breeding resident in north-eastern South Africa. This study set out to monitor the nests of Hooded Vultures and, secondarily, White-backed Vultures Gyps africanus in the Olifants River Private Nature Reserve over two breeding seasons in 2013 and 2014. A total of 12 Hooded Vulture nests, placed mostly in the tree Diospyros mespiliformis, were found along the Olifants River, with an average inter- nest distance of 0.76 km. Nest success was estimated to be between 0.44–0.89 offspring pair−1 y−1 in 2013 and 0.50–0.67 offspring pair−1 y−1 in 2014, which are the first estimates for Hooded Vultures in South Africa. It is thought that nests of this species have been under-reported due to the fact that they are placed within or below the canopy of densely leafed trees and hence difficult to view from aerial surveys. African White-backed Vultures also bred along the Olifants River, with nests placed in clusters of up to six. Nesting density of this species ranged from about 1.0 to 1.2 nests km−1 and nests were predominantly placed in Ficus sycomorus trees.

Designs upon death in ancient Egypt

Much is known about ancient Egyptian medicine from papyri in various museums, which describe treatments consisting of a combination of magical spells, rituals, and practical prescriptions. But although physicians were clearly important members of a pharaoh's entourage, very few of their names survive. One exception is that of Wepwawetemhat. His name and function is written in coloured hieroglyphs alongside painted natural creatures on a fragment of his coffin made of sycamore fig wood dating from about 1975–1790 BC, kept at the Fitzwilliam Museum in Cambridge, UK. It forms part of the museum's engaging exhibition, Death on the Nile (video).

Phytochemical Screening and Antimicrobial Activity of Ficus sycomorus Extracts of the Stem Bark and Leaves on Some Pathogenic Microorganisms

Phytochemical Screening and Antimicrobial Activity of Ficus sycomorus Extracts of the Stem Bark and Leaves on Some Pathogenic Microorganisms

Ethnobotanical Study of Plants Used in the Management of HIV/AIDS-Related Diseases in Livingstone, Southern Province, Zambia.

Faced with critical shortages of staff, long queues, and stigma at public health facilities in Livingstone, Zambia, persons who suffer from HIV/AIDS-related diseases use medicinal plants to manage skin infections, diarrhoea, sexually transmitted infections, tuberculosis, cough, malaria, and oral infections. In all, 94 medicinal plant species were used to manage HIV/AIDS-related diseases. Most remedies are prepared from plants of various families such as Combretaceae, Euphorbiaceae, Fabaceae, and Lamiaceae. More than two-thirds of the plants (mostly leaves and roots) are utilized to treat two or more diseases related to HIV infection. Eighteen plants, namely, Achyranthes aspera L., Lannea discolor (Sond.) Engl., Hyphaene petersiana Klotzsch ex Mart., Asparagus racemosus Willd., Capparis tomentosa Lam., Cleome hirta Oliv., Garcinia livingstonei T. Anderson, Euclea divinorum Hiern, Bridelia cathartica G. Bertol., Acacia nilotica Delile, Piliostigma thonningii (Schumach.) Milne-Redh., Dichrostachys cinerea (L.) Wight and Arn., Abrus precatorius L., Hoslundia opposita Vahl., Clerodendrum capitatum (Willd.) Schumach., Ficus sycomorus L., Ximenia americana L., and Ziziphus mucronata Willd., were used to treat four or more disease conditions. About 31% of the plants in this study were administered as monotherapies. Multiuse medicinal plants may contain broad-spectrum antimicrobial agents. However, since widely used plants easily succumb to the threats of overharvesting, they need special protocols and guidelines for their genetic conservation. There is still need to confirm the antimicrobial efficacies, pharmacological parameters, cytotoxicity, and active chemical ingredients of the discovered plants.

In vitro evaluation of the total phenolic and flavonoid contents and the antimicrobial and cytotoxicity activities of crude fruit extracts with different polarities from Ficus sycomorus

Plants are a good source for discovering new drugs for human benefit. The objective of this study was to determine the total phenolic and flavonoid contents and to probe the antimicrobial and cytotoxic activities of fruit extracts of Ficus sycomorus (F. sycomorus), which is native to the Sultanate of Oman. A study was conducted to measure the total phenolic and flavonoid contents of the methanol extract of this fruit and its derived fractions [n-hexane, chloroform, ethyl acetate, butanol and residual aqueous fractions] by in vitro chemical analyses using the Folin-Ciocalteu reagent assay (FCR) and the aluminium chloride (AlCl3) method. The antimicrobial and cytotoxic activities were assessed using the slightly modified agar disc diffusion method and the brine shrimp lethality (BSL) method. The results of the analysis of the total phenolic content in different fruits extracts showed a significant amount of phenolic compounds, ranging from 1.48 to 213.79 mg of GAE/100 g of powder weight. However, the range of the total flavonoid content among the fruit extracts was found to be 0.100–0.527 mg QE/100 g of powder weight. The antimicrobial activity of the crude fruit extracts at different concentrations against four Gram-positive and Gram-negative bacterial strains, Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Haemophilus influenza (H. influenza), and Proteus spp (P. spp), showed strong activity in the range of 0–15 mm. The highest cytotoxic activity among the same extracts was that of the methanol extract, which had a LC50 value of 1.48 μg/mL, followed by hexane, chloroform, butanol, water and ethyl acetate, with LC50 values of 2.13, 3.16, 7.49, 133.04, and 213.79 μg/mL, respectively, in comparison to the control, DMSO. The findings of the present study suggest that the fruit extracts have significant amounts of total phenolic and flavonoid compounds with potential cytotoxic and antimicrobial activities.

Total flavonoids content and antimicrobial activity of crude extract from leaves of Ficus sycomorus native to Sultanate of Oman

The aim of this study was to prepare crude extracts from the leaves of Ficus sycomorus (F. sycomorus) native to Oman, and determine their total flavonoids content as well as their antimicrobial activity. Powdered leaf samples were extracted with methanol by using maceration method. The resulting crude extract was suspended in water and successively extracted with hexane, chloroform, ethyl acetate and butanol solvents, respectively. Total flavonoids of the above extracts were determined by the aluminum chloride method, and antimicrobial activity of the same extracts was assessed by a slightly modified disc diffusion method against different Gram (+ and −) bacterial strains. The highest flavonoids content was found in chloroform crude extract followed by that of hexane, butanol, ethyl acetate, and water extracts, respectively. Tested against four bacterial strains, the extracts showed activity in the range of 0–12 mm, using amoxicillin as standard. The present findings could establish this plant as a potential source of antibiotics.