This exploration examines the effects of the Cattaneo–Christov double diffusion in the Ostwald-de-Waele nanofluid flow on a rotating disk with varying thicknesses. The incorporation of the impacts of the bioconvection microorganisms increases the stability of the nanofluids. The slip boundary constraint is taken at the disk. The flow system is based on the Buongiorno nanofluid model. The envisioned fluid flow model incorporates heat transmission properties that are affected by nanoparticle volume fraction, Brownian motion, and thermophoresis. The numerical software bvp4c method is affianced. The presented diagrams portray the correlation of the protuberant parameters with the associated profiles given with cogent arguments. It is heeded that higher estimates of the thermal and solutal relaxation parameters dwindled the thermal and mass profiles. Furthermore, the motile microorganism distribution is diminished for larger counts of the Peclet number. A comparison table is also included to justify the truthfulness of the proposed model.