The permeability of the coal seam is the main petrophysical property controlling the performance of the ECBM operation, since it affects both the CO2 injection and CH4 recovery. In the present paper, coal swelling of intact coal samples is studied both under unconstrained and constrained conditions. Unconstrained swelling experiments are performed in a view cell under a static high pressure gas atmosphere, whereas gas injection experiments are carried out in a flow cell, where the sample is subjected to a given hydrostatic confinement. Both experiments are performed by using different gases, namely He, CO2, CH4 and N2, and under typical coal seam conditions, i.e. at high pressure and at 45 ∘C. The results of the unconstrained coal sample showed that swelling increases monotonically with pressure up to a few percents for adsorbing gases, with CO2 swelling coal more than CH4 that swells more than N2, whereas for helium, a non-adsorbing gas, volume changes are negligible. The results of the flow experiments were successfully described using a mathematical model consisting of mass balances accounting for gas flow and adsorption, and mechanical constitutive equations for the description of porosity and permeability changes during injection. Results showed increase in permeability with decreasing effective pressure on the sample. Moreover, when CO2 is used a permeability reduction was observed compared to Helium, which can be explained by taking into account the effects of swelling on the flow dynamics.