Sweet potato is the second most important root crop after cassava in Nigeria. Due to decline in Nigeria‘s economy in recent years, the production of sweet potato has significantly increased from 2.4 million metric tonnes in 2000 to 4.1 million metric tons in 2017 to meet up with its demand for local consumption. However, the profitable production of the crop is being threatened by virus diseases such as Sweet potato feathery mottle virus (SPFMV), Sweet potato mild mottle virus (SPMMV), Sweet potato chlorotic stunt virus (SPCSV), Sweet potato leaf curl virus (SPLCV), and Cucumber mosaic virus (CMV). Useful information about these viruses is instrumental in the effective management of the crop in Nigeria. This paper reviewed the major viruses that affect sweet potato production in Nigeria.