Time-dependent reliability (TDR) is the possibility that a structure or system under consideration can perform the intended function under specified service conditions over a given time instant under fuzzy uncertainty. This paper is mainly concerned to identify fuzzy variables, generate the membership function of the input variables and output quantities, analyze timedependent performance level, estimate the possibility safety index, and evaluate the TDR of the structures. To evaluate TDR by a possibilistic approach, the fuzzy uncertainty that is characterized by membership function is considered. The type of uncertainty defines the method of reliability analysis, i.e., aleatory uncertainty possesses a probabilistic approach, whereas epistemic uncertainty leads to a possibilistic approach. The TDR analysis of the structures subjected to sustained load and corrosion based on probability theory is well developed. On the contrary, the TDR of structures subjected to combined effects sustained load, corrosion, creep, and shrinkage based on possibility theory lack research. Thus, this paper is significant to evaluate the TDR of structures subjected to the aforementioned effects based on possibility theory. However, it requires a rigorous procedure, a single-loop optimization method (SLOM) is employed to evaluate the TDR of structures involving epistemic uncertainty. To enhance the validation of the proposed approach, several examples are thoroughly carried out.