The implementation of effective and sustainable Structural Health Monitoring (SHM) systems for the evaluation of infrastructure conditions is critical to address the deterioration and damage experienced by structures worldwide. Given the vast number of structures involved, resorting to traditional in-situ visual inspections and data gathering methods is becoming increasingly unfeasible. Multi-Temporal Interferometric Synthetic Aperture Radar (MT-InSAR) has recently gained attention as a viable solution for long-term SHM. This remote sensing technique combines multiple satellite radar images to measure changes in the Earth’s surface over time. Unlike conventional techniques, MT-InSAR does not require in-situ installations and offers extensive coverage, enabling observations across diverse location and structures. However, the applicability of MT-InSAR monitoring depends on the relatively unpredictable distribution and location of permanent scatterers (PSs), which are influenced by surface characteristics and vegetation changes. Evaluating the reliability and capacity of MT-InSAR is therefore crucial to enhance its effectiveness in assessing the location and extent of structural damage. In this study, we present an effective approach to determine the optimal number and position of PSs for detecting different structural damage mechanisms. The approach is exemplified through a case study of a quay wall in Amsterdam, with data inputs simulated using the Finite Element Method. The proposed method has the potential to evaluate the feasibility of MT-InSAR for a broader range of scenarios, enabling to detect specific structural conditions.