Given the need for inclusivity in a bid to curtail multidimensional poverty, hunger, and inequality (as reflected in the Sustainable Development Goals (SDG) 1, 2, and 10 respectively) and in the face of struggles to achieve decent work and economic growth (SDG 8) as well as responsible consumption and production (SDG 12), the main objective of our paper was to determine how microfinance institutions (MFIs) contributed to entrepreneurial successes of physically-challenged persons residing in Awka South Local Government Area (LGA), Anambra, Nigeria. A sample was drawn from the physically challenged community operating business shops and enterprises in Awka South LGA, and descriptive survey research was employed. Copies of a structured questionnaire were distributed and collected on the spot based on the exponential discriminative snowball sampling. Responses were analyzed using pie charts, frequency distributions, and percentages, while the chi-square distribution test was used to test the hypotheses. Our major findings are that, apart from access to loans, the respondents were not aware of other services rendered by microfinance institutions and that they encountered difficulties in accessing credit facilities from MFIs sequel to protocols enshrined in their banking operations. This led to the conclusion that the contributions of microfinance institutions towards the growth of enterprises owned by physically-challenged entrepreneurs in Awka South LGA was suboptimal, although some respondents had successful business startups and scale ups as a result of interventions from MFIs. Our paper, therefore recommends that, in order to build a resilient society, MFIs operating in Awka South LGA should intensify and sustain media awareness on entrepreneurship programmes they offer to physically-challenged persons as well make their services more accessible. Again, the government of Anambra State should adequately sustain entrepreneurial programmes mapped out for physically-challenged persons so that they can become entrepreneurs rather than depend on others for their survival. Keywords: Entrepreneurship, Microfinancing, Physically-challenged, Self-employment JEL Codes: M13, G21, J71, J23, D63