In this study, a new nonlinear mathematical programming model of mixed integer was presented to formulate the problem of designing a sustainable closed loop supply chain, in which the three aspects of sustainability, i.e., social effect such as job creation, customer satisfaction, and distributors, environmental effects such as reducing air pollution, and economic effects such as reducing supply chain costs, increasing supply chain reliability, quality of returned products by customers, and product routing were considered. In order to solve the proposed model, a new hybrid metaheuristic algorithm based on the distinctive features of gray wolf algorithm and genetic algorithm was proposed in addition to MOPSO and NSGA-II algorithms. After tuning their parameters by the Taguchi method, their performance in problems with different dimensions was tested and evaluated by MID, DM, and SM criteria. The results of statistical analysis of indices indicated that no significant difference between the performance of the three algorithms at 5% error level. In general, GW-NS, NSGA-II and MOPSO algorithms had better performance in terms of MID index, respectively. In addition, GW-NS, NSGA-II, and MOPSO algorithms performed better in terms of DM index. NSGA-II, MOPSO, and GW-NS algorithms performed better in terms of SM index, respectively. In addition, the variability of DM index in all three algorithms was almost the same, but in MID index, GW-NS algorithm, and in SM index, MOPSO algorithm had the highest change and less sustainability.