Sustained Activation Research Articles

Mechanisms underlying age-associated exacerbation of pulmonary veno-occlusive disease.

Pulmonary veno-occlusive disease (PVOD) is a rare but severe form of pulmonary hypertension characterized by the obstruction of pulmonary arteries and veins, causing increased pulmonary artery pressure and leading to right ventricular (RV) heart failure. PVOD is often resistant to conventional pulmonary arterial hypertension (PAH) treatments and has a poor prognosis, with a median survival time of 2-3 years after diagnosis. We previously showed that the administration of a chemotherapy agent mitomycin C (MMC) in rats mediates PVOD through the activation of the eukaryotic initiation factor 2 (eIF2) kinase protein kinase R (PKR) and the integrated stress response (ISR), resulting in the impairment of vascular endothelial junctional structure and barrier function. Here, we demonstrate that aged rats over 1 year exhibit more severe vascular remodeling and RV hypertrophy than young adult rats following MMC treatment. This is attributed to an age-associated elevation of basal ISR activity and depletion of protein phosphatase 1, leading to prolonged eIF2 phosphorylation and sustained ISR activation. Pharmacological blockade of PKR or ISR mitigates PVOD phenotypes in both age groups, suggesting that targeting the PKR/ISR axis could be a potential therapeutic strategy for PVOD.

Economic growth versus the environment: government spending, trust, and citizen support for environmental protection

ABSTRACT Support for sustainability activities among citizens will also increase the probability of more sustainable choices being made by governments. In this study, we investigate the relationship between prioritization of environmental protection over economic growth and government spending on environmental protection in 27 OECD countries and more than 65 000 respondents. Drawing on the perspectives of the thermostatic model, complex belief systems and cognitive dissonance theory, we hypothesize that government spending and attitudes towards environmental protection are related. We further argue that this relationship will be moderated by trust in government. To investigate our hypotheses, we employ OECD statistics on government spending in combination with survey data from WVS and EVS from the years 1995 to 2019. Our findings show that increasing government spending on environmental protection is related to attitudes in favor of economic growth at the expense of environmental concerns, a relationship which is significantly strengthened by having low trust in government.

HOTAIR Promotes the Hyperactivation of PI3K/Akt and Wnt/β-Catenin Signaling Pathways via PTEN Hypermethylation in Cervical Cancer.

The mechanisms underlying the sustained activation of the PI3K/AKT and Wnt/β-catenin pathways mediated by HOTAIR in cervical cancer (CC) have not been extensively described. To address this knowledge gap in the literature, we explored the interactions between these pathways by driving HOTAIR expression levels in HeLa cells. Our findings reveal that HOTAIR is a key regulator in sustaining the activation of both signaling pathways. Specifically, altering HOTAIR expression-either by knockdown or overexpression-significantly influenced the transcriptional activity of the PI3K/AKT and Wnt/β-catenin pathways. Additionally, we discovered that HIF1α directly induces HOTAIR transcription, which in turn leads to the epigenetic silencing of the PTEN promoter via DNMT1. This process leads to the sustained activation of both pathways, highlighting a novel regulatory axis involving HOTAIR and HIF1α in cervical cancer. Our results suggest a new model in which HOTAIR sustains reciprocal activation of the PI3K/AKT and Wnt/β-catenin pathways through the HOTAIR/HIF1α axis, thereby contributing to the oncogenic phenotype of cervical cancer.

Emerging occupational risks in green jobs: a review.

Green jobs are to be understood as those jobs directly associated with specific sustainability issues and activities related to the efficiency, quality and innovation of goods and services offered, from an eco-sustainability perspective. The objective of the research was to fill knowledge gaps of new and emerging environmental and occupational risks related to sustainable activities and to understand the impact these might have on workers' psychological and physical well-being. A selection of several scientific articles and a critical analysis of the selected articles was carried out from the perspective of defining the concept of "emerging occupational risks in green jobs," using different keywords in the title or abstract as search criteria. Emerging occupational risks, most prevalent in the green sector are those determined by the rapid introduction of new technologies, new materials, new processes and work organizations. In order to be able to improve prevention and protection at work, it is necessary to act on a more careful and adequate risk assessment, the definition of new professional figures expert in green issues, the expansion of research and development of scientific knowledge, and the improvement of ergonomic aspects. Int J Occup Med Environ Health. 2024;37(3):244-56.

Sustainability reporting in selected automotive companies

Abstract The benefits of sustainability reporting are indisputable. These include, first and foremost, building trust. Transparency on non-financial performance can help reduce reputational risk and open a dialogue with stakeholders. Transparent sustainability reporting is also a sign of openness and responsibility. Efforts to develop the economy sustainably include the development of reporting concepts in this sphere. Sustainability activities are becoming an increasingly important element of business reports. This article aims to present and verify the current sustainability reporting at the level of comparison of reported indicators of selected automotive companies in the context of the most widely used Global Reporting Initiative systematics and the upcoming requirements defined by the Corporate Sustainability Reporting Directive (CSRD). It focuses on study cases and identifies good practices and difficulties of sustainable reporting in the automotive industry. This study used the case study method on selected automotive industry companies. The case study analyses a defined problem consisting of a real situation and information as a methodological tool. The findings show that the world’s major automotive companies are broadly endeavouring to realise sustainability practices. The main conclusion of the analysis is that the Environmental, Social, and Governance (ESG) framework and the Global Reporting Initiative (GRI), in addition to being complementary, can be combined not only to improve the strategic management of an organisation but also, in a broader context, serve the well-being of the local community and society at large. The article organises and systematises knowledge about the ESG concept and the GRI standard, which currently play an important role in sustainability reporting.

Lessons Learned Implementing Syringe Services Programs at Rural Health Departments in Kentucky.

Until recently, most syringe services programs (SSPs) in the United States operated in metropolitan areas. This study explores how SSP implementers at rural health departments in Kentucky secured support for SSP operations. In late 2020, we conducted in-depth, semi-structured interviews with 18 people involved with rural SSP implementation in Kentucky. Participants were asked to reflect on their experiences building support for SSP operations among rural health department staff and community members. Participants reported that attitudes and beliefs about SSP implementation among rural health department staff shifted quickly following engagement in educational activities and interaction with SSP clients. Participants explained that successful SSP implementation at rural health departments required sustained educational activities among community members and authorizing authorities. Future work should explore how rural communities may advocate for low-threshold and evidence-based policies that support the provision of harm reduction services.

Qing-Luo-Yin Eased Adjuvant-Induced Arthritis by Inhibiting SIRT1-Controlled Visfatin Production in White Adipose Tissues.

Nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 regulates both metabolism and immune functions. This study investigated if SIRT1 inhibitory property of herbal formula Qing-Luo-Yin (QLY) contributed to its anti-rheumatic effects. Adjuvant-induced arthritis (AIA) rats were treated by QLY and nicotinamide mononucleotide (NMN, a biosynthesis precursor of NAD) for 38 days. After sacrifice, blood, paws, liver and white adipose tissues (WAT) were collected. Pre-adipocytes were cultured by the rats' serum. The medium was used for monocytes culture. Some pre-adipocytes were treated by QLY-derived SIRT1 inhibitors. SIRT1 was silenced or overexpressed beforehand. The samples were subjected to kits-based quantification, polymerase-chain reaction, western-blot, immunofluorescence, and histology experiments. AIA rats experienced significant fat loss in liver and WAT. Expression of many SIRT1-related signals like PPARγ, PGC-1α, HSL, ATGL and CPT-1A were altered. QLY attenuated all these abnormalities and joint injuries. By pan-acetylation up-regulation, visfatin was obviously reduced in QLY-treated AIA rats' blood (from 191.8 to 127.0 pg/mL). NMN sustained SIRT1 activation by replenishing NAD, and weakened these effects. QLY-containing serum and the related compounds showed similar impacts on pre-adipocytes, resembling the changes in QLY-treated AIA rats' WAT. These treatments suppressed AIA serum-induced visfatin secretion (from 49.3 to 36.1 and 30.7 pg/mL). This effect was impaired by SIRT1 overexpression. The medium from the compounds-treated pre-adipocytes impaired NF-κB activation in AIA serum-cultured monocytes. Besides fat depletion, SIRT1 up-regulation in rheumatic subjects' WAT promotes visfatin production, and exacerbates inflammation. SIRT1 inhibition in WAT is an anti-rheumatic way of QLY independent of immune regulation.

Localized and Long-Lasting Adaptation in Dragonfly Target-Detecting Neurons.

Some visual neurons in the dragonfly (Hemicordulia tau) optic lobe respond to small, moving targets, likely underlying their fast pursuit of prey and conspecifics. In response to repetitive targets presented at short intervals, the spiking activity of these "small target motion detector" (STMD) neurons diminishes over time. Previous experiments limited this adaptation by including intertrial rest periods of varying durations. However, the characteristics of this effect have never been quantified. Here, using extracellular recording techniques lasting for several hours, we quantified both the spatial and temporal properties of STMD adaptation. We found that the time course of adaptation was variable across STMD units. In any one STMD, a repeated series led to more rapid adaptation, a minor accumulative effect more akin to habituation. Following an adapting stimulus, responses recovered quickly, though the rate of recovery decreased nonlinearly over time. We found that the region of adaptation is highly localized, with targets displaced by ∼2.5° eliciting a naive response. Higher frequencies of target stimulation converged to lower levels of sustained response activity. We determined that adaptation itself is a target-tuned property, not elicited by moving bars or luminance flicker. As STMD adaptation is a localized phenomenon, dependent on recent history, it is likely to play an important role in closed-loop behavior where a target is foveated in a localized region for extended periods of the pursuit duration.

42 Motives and Barriers of Active Transportation as a Sustainable Physical Activity among Young Lithuanian Adults

42 Motives and Barriers of Active Transportation as a Sustainable Physical Activity among Young Lithuanian Adults

Expanding community-based participatory action research practices to clubhouses through sustainable research activities.

There is growing utilization and acknowledgement of the benefits of community-based participatory action research (CBPAR) in advancing health practices and equity. However, the sustainability and full impact of CBPAR in health care settings faces many obstacles and limitations. The present article examines the synergies between CBPAR and Clubhouse programs, presents the demonstration and ongoing implementation of sustainable CBPAR practices at Fountain House in New York City, and offers lessons learned for other Clubhouses and similar programs seeking to integrate CBPAR. Alignment in practice and principles between CBPAR and Clubhouse programs are presented. The innovation and ongoing sustainable CBPAR practices in the Fountain House Clubhouse program are examined with a contribution of practice guidance for other Clubhouse and similar programs in further adopting and learning CBPAR into participatory health practices. Clubhouse psychosocial rehabilitation programs present structurally conducive settings for the success and sustainability of CBPAR activities and projects. The Fountain House examination and demonstration of integrating CBPAR sustainably into core Clubhouse programming presents opportunities for further integration, research, and practice guidance in uniquely leveraging features of the Clubhouse model to advance health equity and rehabilitative outcomes through CBPAR. The opportunity for incorporating structural CBPAR activities within Clubhouse programs can be informed by the experience, processes, and lessons applied in the Fountain House example. Further research into the rehabilitation, program, and equity benefits of Clubhouse and CBPAR integration could uniquely contribute to the advancement of sustainable participatory research practices across the mental health field generally. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Spinal astrocyte-derived interleukin-17A promotes pain hypersensitivity in bone cancer mice

Spinal microglia and astrocytes are both involved in neuropathic and inflammatory pain, which may display sexual dimorphism. Here, we demonstrate that the sustained activation of spinal astrocytes and astrocyte-derived interleukin (IL)-17A promotes the progression of mouse bone cancer pain without sex difference. Chemogenetic or pharmacological inhibition of spinal astrocytes effectively ameliorates bone cancer-induced pain-like behaviors. In contrast, chemogenetic or optogenetic activation of spinal astrocytes triggers pain hypersensitivity, implying that bone cancer-induced astrocytic activation is involved in the development of bone cancer pain. IL-17A expression predominantly in spinal astrocytes, whereas its receptor IL-17 receptor A (IL-17RA) was mainly detected in neurons expressing VGLUT2 and PAX2, and a few in astrocytes expressing GFAP. Specific knockdown of IL-17A in spinal astrocytes blocked and delayed the development of bone cancer pain. IL-17A overexpression in spinal astrocytes directly induced thermal hyperalgesia and mechanical allodynia, which could be rescued by CaMKIIα inhibitor. Moreover, selective knockdown IL-17RA in spinal Vglut2+ or Vgat+ neurons, but not in astrocytes, significantly blocked the bone cancer-induced hyperalgesia. Together, our findings provide evidence for the crucial role of sex-independent astrocytic signaling in bone cancer pain. Targeting spinal astrocytes and IL-17A/IL-17RA-CaMKIIα signaling may offer new gender-inclusive therapeutic strategies for managing bone cancer pain.

GREEN LOGISTICS: DEFINING THE FACTORS INFLUENCING EMPLOYEE’S ENGAGEMENT IN SUSTAINABILITY, AND LINKING IT TO THE CORPORATE IDENTITY AND ITS SOCIAL RESPONSIBILITY

This study investigates the degree of congruence between employees' perceptions of company sustainability and their use of sustainable activities outside of work. A total of 217 participants from logistics enterprises in Istanbul completed a detailed questionnaire that assessed demographics, corporate social responsibility (CSR), pro-environmental behavior (PEB), and organizational identification. The findings show a robust relationship between CSR perception and PEB, confirming the idea that employees who see their employer as socially responsible are more inclined to take pro-environmental measures. Furthermore, organizational identification predicts PEB, demonstrating the importance of employee commitment to the business in generating sustainable habits. The mediation analysis also demonstrates that OI mediates the link between CSR and PEB, emphasizing its significance in influencing workers' sustainable actions. The report emphasizes the need of organizations improving their CSR programs and promoting organizational identification in order to raise sustainability practices both within and outside of the workplace. Limitations include the study's narrow emphasis on a single city and industry, which suggests opportunities for larger geographical and sectoral replication.

Sustained Microglial Activation Promotes Synaptic Loss and Neuronal Dysfunction after Recovery from ZIKV Infection.

Zika virus (ZIKV), transmitted by Aedes mosquitoes, has been a global health concern since 2007. It primarily causes fetal microcephaly and neuronal defects through maternal transmission and induces neurological complications in adults. Recent studies report elevated proinflammatory cytokines and persistent neurological alterations post recovery, but the in vivo mechanisms remain unclear. In our study, viral RNA loads in the brains of mice infected with ZIKV peaked at 7 days post infection and returned to baseline by day 21, indicating recovery. RNA sequencing of the cerebral cortex at 7 and 21 days revealed upregulated genes related to neuroinflammation and microglial activation. Histological analyses indicated neuronal cell death and altered neurite morphology owing to severe neuroinflammation. Additionally, sustained microglial activation was associated with increased phospho-Tau levels, constituting a marker of neurodegeneration. These findings highlight how persistent microglial activation leads to neuronal dysfunction post ZIKV recovery, providing insights into the molecular pathogenesis of ZIKV-induced brain abnormalities.

Sustainability and financial performance in the banking industry of the United Arab Emirates

Today's banking industry achieving sustainable profitability necessitates by integrating economic, environmental, and social factors due to pressing environmental concerns. This study investigates the impact of sustainability on financial performance in the United Arab Emirates (UAE) banking sector, using the Autoregressive Distributed Lag (ARDL) and Bootstrapping ARDL approaches on data from 2002 to 2022. The analysis revealed that economic sustainability, environmental and social sustainability exhibit a significant impact on financial performance in the short run and the long run at a (p < 0.05). 1% of economic sustainability activities increases Return on Assets (ROA) by 0.73 and Return on Equity (ROE) by 0.64. 1% of environmental sustainability activities decreases ROA by −0.28 and increases ROE by 0.35. 1% of social sustainability activities increases ROA by 0.47 and ROE by 0.42. To improve long-term profitability, this study emphasizes how crucial it is for the banking industry in the UAE to strategically integrate sustainability principles. These findings highlight the need to promote sustainability in the banking sector for environmental improvement, offering insights for UAE regulators and stimulating additional research.

Emotion and birth control: Emotion regulation ERPs differ based on menstrual cycle phase and hormonal contraceptive use

While hormonal contraceptives (HCs) like oral contraceptive pills (OCs) and intrauterine devices (IUDs) can reportedly influence mood, the evidence is mixed, and the mechanisms remain unclear. Emotion reactivity and regulation processes may be hormone-sensitive and underlie these mood changes. This study sought to investigate the role of the menstrual cycle and HC use in emotion regulation using ERP measures during an emotion regulation paradigm. Participants with a natural cycle (NC) were measured in the mid-follicular and mid-luteal phase (within-subject design, n = 26), and compared with OC (n = 36) and IUD (n = 25) users. The centroparietal late positive potential (LPP) reflected negative emotion reactivity and its modulation by cognitive reappraisal served as a marker for emotion regulation processing. NC participants had a lower LPP amplitude in the mid-luteal compared to the mid-follicular phase. Reactivity to negative emotional stimuli decreased over time in the mid-luteal phase, whereas the HC groups showed sustained LPP activation. Reappraisal led only to significant LPP changes in the mid-follicular phase, and not in the mid-luteal phase or HC groups. Our results showed a specific left frontal activity (FR-LPP) in the contrast that reflected emotion regulation processing. This activity was highest in the mid-follicular phase, and was significantly different from the OC users but not from the IUD group. Higher self-reported PMS symptoms were associated with stronger effects on the reduced mid-luteal LPP activity and with lower FR-LPP amplitude in the mid-follicular phase. No effect of OC phase (active pill use versus pill pause) was found. These findings add insights into the neurophysiological underpinnings of hormone-related mood changes and demonstrate the importance of considering hormonal status and PMS symptoms in emotion research.

Sport in Times of Crisis: Impacts of the COVID-19 Pandemic on the Sport and Physical Exercise Habits of College Students at SEC Member Institutions

With the COVID-19 pandemic in the rear window, the sport industry ramped up efforts to evaluate the financial and cultural detriment of the global public health crisis. Therefore, this study aimed to assess how the altered sport and physical exercise habits of college students at Southeastern Conference (SEC) member institutions impacted their physical and mental well-being. Drawing from social ecology theory, data were collected through a qualitative online survey consisting of open-ended questions, disseminated via email to SEC college students. Study findings indicate the critical role of access to physical exercise and sports in the overall well-being of society and may prove invaluable for addressing future public health emergencies and crises. Theoretical and practical recommendations include the development of sustainable outdoor recreation activities as well as coping strategies and alternatives to traditional sports and physical exercise (e.g., immersive virtual reality options).

Achieving the United Nations sustainable development goals – innovation diffusion and business model innovations

Purpose The study aims to analyse the race towards green development and United Nations sustainable development goals (SDGs) in the cases of Huawei and Shell. Both companies are the leaders in their respective industries. Huawei is an example case study representing the information and communications technology (ICT) industry whereas Shell is an example case study representing the oil and gas industry. The research analyses of the races in achieving UN SDGs were undertaken based on the innovation diffusion framework with the use of machine learning algorithms trained to extract data on sustainability activities and initiatives. Design/methodology/approach The research analyses the two case studies of Huawei and Shell. The research was undertaken through the steps of training machine learning algorithms, industry benchmarking and evaluating the performance of the race. The analyses regarding the activities and initiatives of Huawei and Shell in contributing towards SDGs are based on the data in the past 10 years (Years 2010–2019) using machine learning to extract data on sustainability activities and initiatives. In the case of Huawei, 313 sustainability reports were fed to the unsupervised machine learning algorithms revealing 15,101 sustainability actions and initiatives related to UN SDGs in the ICT industry. In the case of Shell, 2,015 sustainability reports were fed to the unsupervised machine learning algorithms revealing 47,365 sustainability actions and initiatives related to UN SDGs in the oil and gas industry. Findings The analyses of findings revealed that Huawei and Shell performed very well in progressing towards the UN SDGs. Huawei had strong performance in the ICT industry with regard to SDGs No. 3, 4, 7, 8, 11, 12 and 16 while Shell had strong performance in the oil and gas industry with regard to SDGs No. 3, 4, 6, 7, 8, 12 and 16. Both companies had placed a focus on achieving SDG 12 responsible consumption and production, SDG 7 affordable and clean energy and SDG 4 quality education. The synthesised business model innovations of Huawei and Shell had shown their environmental, social and governance strategies – Huawei’s 2030 vision for green development and Shell’s 2050 vision for net zero emissions. Practical implications The five pillars of people, planet, prosperity, peace and partnership according to the UN 2030 agenda for sustainable development have shown the way a company operates to promote sustainable eco-systems. The extent to which both Huawei and Shell link corporate strategies to the UN SDGs has reflected their implementation progress. Furthermore, the business model innovations of Huawei and Shell provides a useful framework which can be applied to encourage other companies/organisations in various industries to undertake ESG activities in practice. Originality/value The main contribution of this research is the application of machine learning algorithms and the innovation diffusion model in analysing the SDGs performance. The study applies the innovation diffusion framework to explore strategic actions and initiatives of Huawei and Shell in transitioning towards sustainability. The use of machine learning algorithms has identified their sustainability approach in achieving the UN SDGs.

Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal

Hematopoietic stem cells surrender organelles during differentiation, leaving mature red blood cells (RBC) devoid of transcriptional machinery and mitochondria. The resultant absence of cellular repair capacity limits RBC circulatory longevity, and old cells are removed from circulation. The specific age-dependent alterations required for this apparently targeted removal of RBC, however, remain elusive. Here, we assessed the function of Piezo1, a stretch-activated transmembrane cation channel, within subpopulations of RBC isolated based on physical properties associated with aging. We subsequently investigated the potential role of Piezo1 in RBC removal, using pharmacological and mechanobiological approaches. Dense (old) RBC were separated from whole blood using differential density centrifugation. Tolerance of RBC to mechanical forces within the physiological range was assessed on single-cell and cell population levels. Expression and function of Piezo1 were investigated in separated RBC populations by monitoring accumulation of cytosolic Ca2+ and changes in cell morphology in response to pharmacological Piezo1 stimulation and in response to physical forces. Despite decreased Piezo1 activity with increasing cell age, tolerance to prolonged Piezo1 stimulation declined sharply in older RBC, precipitating lysis. Cell lysis was immediately preceded by an acute reversal of density. We propose a Piezo1-dependent mechanism by which RBC may be removed from circulation: Upon adherence of these RBC to other tissues, they are uniquely exposed to prolonged mechanical forces. The resultant sustained activation of Piezo1 leads to a net influx of Ca2+, overpowering the Ca2+-removal capacity of specifically old RBC, which leads to reversal of ion gradients, dysregulated cell hydration, and ultimately osmotic lysis.

Effect of Physical Activity on Students’ Social Skills :Research Factor Analysis at South Tangerang Elementary Schools

This study investigates the impact of physical activity on the social skills of elementary school students in South Tangerang. Utilizing a factor analysis approach, the research examines various dimensions of physical activity—including frequency, duration, and type—and their correlations with key social competencies such as communication, teamwork, empathy, and conflict resolution. A sample of 164 students from ten elementary schools in South Tangerang was selected through stratified random sampling to ensure representativeness. Data were collected using validated questionnaires and observational assessments conducted over six months. Statistical analysis revealed that regular participation in structured physical activities significantly enhances students' social skills, with team-based sports showing the most substantial positive effects. Additionally, the study identified specific factors within physical activity programs that contribute to developing social competencies, including cooperative gameplay, leadership opportunities, and inclusive participation strategies. These findings suggest that integrating comprehensive physical activity programs into the elementary school curriculum can foster essential social skills, thereby contributing to students' overall personal and academic development. The study recommends that educators and policymakers prioritize implementing and supporting diverse physical activity initiatives to promote a holistic educational environment. Future research should explore the long-term effects of sustained physical activity on social skills and investigate the potential moderating variables such as socioeconomic status and cultural background.

Editorial: Enhancing Regional Resilience

Welcome to this special issue where we explore the role of hospitality services in sustaining communities especially in terms of enhancing regional resilience. In this issue, a range of topic areas are covered including service learning, operational risk management, hotel subscription models, staycations, virtual reality, cultural resilience, luxury transportation and Vanaprastha Tourism. With each of the research papers in this issue, the focus is on the provision of hospitality services and in particular the unique relationship between hosts and guests. The studies show that various factors need to come together for quality hospitality services to be delivered and that it is the interplay between hosts and guests that has important implications for organisations and associated communities. The studies highlight that hospitality is about creating spaces where a range of services are experienced, e.g., food, drink, accommodation, transportation, and entertainment. In turn, hospitality spaces are at the intersections of a range of issues such as social interactions, physical spaces, symbolic places, loyalty, transformation, embodiment, inclusivity, and resilience. These papers present insights into the importance of hospitality services to not only travellers and their experiences and memories but also to sustained social and economic activities of communities and their respective regions. They contribute significantly to understanding and knowledge of regional resilience and augment past, present and emerging discourses on the nature and role of hospitality and provision of hospitality services for enhancing regional and community resilience and sustainability. They generate ideas for policies, practices and future research. Individually and collectively, the insights provided by these papers lend opportunities for establishing resilient and sustainable hospitality operations into the future.