By combining the advantages of the multi-strut concept in cable dome structures with aluminum alloy material, a new type of prestressed spatial structure—the multi-strut aluminum alloy suspen-dome with a large opening—has been developed by integrating a lower prestressed support system into an aluminum alloy reticulated shell. The optimal structural configuration was determined by comparing the static, stability, and economic performance of three types of upper chord mesh topologies for this structure. Subsequently, an analysis of the static performance and large-scale parameters affecting the structural stability of the optimal grid topology was conducted. The study explored the influence of structural prestressing, overall shape, and support stiffness—encompassing three categories and seven parameters—on structural stability and material consumption. Additionally, the effects of initial imperfections and load distribution forms on structural stiffness and stability were further examined. Finally, the static properties, stability, and economic indicators of the structure were compared with two other structural systems: the steel suspen-dome and the cable dome. The results indicate that the pentagonal grid topology provides the best structural performance and that the structure is sensitive to cooling effects. Optimal values for key design parameters, such as the rise-span ratio and thickness-span ratio, were identified. Moreover, the economic advantages of the aluminum alloy suspen-dome compensate for its mechanical performance shortcomings compared to the steel suspen-dome. These findings offer innovative solutions and a scientific basis for the selection and stability design of aluminum alloy suspen-dome structures.