Suspended System Research Articles

Activity enhancement and the anammox mechanism under low temperature via PVA-SA and nano Fe2O3-PVA-SA entrapped beads

Anaerobic ammonia-oxidizing bacteria (AAOB) have a long growth time and low activity at low temperatures. In suspended systems, sludge is easily lost, which limits the mainstream application of anaerobic ammonia oxidation (anammox).Entrapment provides effective ideas for solving these problems. In this study, polyvinyl‑sodium alginate (PVA-SA) and nano Fe2O3-PVA-SA entrapment beads were prepared to discuss the effectiveness of entrapment enhanced anammox sludge at low temperatures. The differences in the entrapped beads and granules were compared to analyze the strengthening mechanism. The results show that the nitrogen removal performance of granules, PVA-SA and nano Fe2O3-PVA-SA entrapped beads, first decreased and then increased during the cooling and low-temperature operation. Nano Fe2O3-PVA-SA entrapped beads showed the smallest decline and the highest degree of recovery. Reaction metering ratio (△NO2−-N/△NH4+-N and △NO3−-N/△NH4+-N) showed that entrapment could realize Nitrite oxidizing bacteria (NOB) inhibition and improve the activity of denitrifying bacteria (DNB) to promote the removal of total nitrogen by providing a strict anaerobic environment. The results demonstrate that entrapment is beneficial for maintaining the content of heme c, specifically, nano Fe2O3 can stimulate its production, and is beneficial for alleviating the reduction of hydrazine dehydrogenase (HDH) enzyme activity. The extracellular polymeric substances (EPS) content and analysis showed that entrapment does not change the composition of EPS, and can maintain the EPS content. Nano Fe2O3 can stimulate AAOB to secrete more EPS to maintain sludge stability. From a molecular perspective, entrapment can maintain the expression of functional genes, promote the enrichment of AAOB, thus improving the nitrogen removal performance from the dual perspectives of “quality” and “quantity”.

Acute Toxicity Assay Based on Electrochemical Method for Detection of Antibiotic Residues in Water

AbstractIn this work, the bacteria suspended in solution or immobilized in the biofilm were employed to study whether bacterial electrochemistry can reflect the impacts of the antibiotic residues in water on microorganisms. In the sensing system with immobilized bacteria, the tested antibiotics of 10∼40 mg/L showed an opportunity to inhibit respiration over a short time and the combined effect of these antibiotics exhibited a complex dose‐dependence. The resistance was induced for the immobilized bacteria in the repeated measurement over a long‐term period, which was fortunately solved by refreshing the biofilm via a nutrient supplementation. In the solution system, bacterial respirations were promoted by the tested antibiotics even at concentrations up to 160 mg/L, but β‐glucosidase activity was inhibited by only 0.05 mg/L antibiotic. Cu2+ and Zn2+ were further inducted in the suspended system, and the combination of metals and antibiotics showed an obvious antagonistic effect. Real water detection indicated that the bacterial electrochemical method was expected to warn the water qualities with a sudden change by an appropriate testing condition.

Effect of the combined centre of gravity height on the ride comfort of suspended monorail train under crosswinds

The combined centre of gravity (CCOG) height of a suspended monorail train may have a certain influence on the centrifugal forces acting on the train under crosswinds, and changes in centrifugal forces will further affect the dynamic interactions among the crosswind, the vehicle and the bridge subsystem. To investigate the effect of CCOG height on the dynamic behaviour of the train, this paper proposes an improved wind-vehicle-bridge coupling dynamics model considering the CCOG height for the suspended monorail system, in which the uneven passenger weight distribution is simulated with various vehicle parameters, and the aerodynamic wind forces acting on the running vehicles and bridge are simulated considering the effect of resultant wind yaw angle. The influences of passenger number, wind velocity, and vehicle speed on the dynamic behaviours of suspended monorail trains are also explored. The results indicate that the suspended monorail train has a certain self-balancing ability due to its unique structure type, which causes the lateral responses of the car body to attenuate with the increasing car weight. In addition, it is conservative to not consider the effect of CCOG height in the lateral ride comfort evaluation of the suspended monorail train subject to crosswinds.

Investigation of the structural reliability of technological solutions of suspended ceilings

The object of research is fasteners for suspended ceiling systems. The purpose of the study was to test the strength of non-standard solutions for fixing suspended ceilings. The relevance of this study is confirmed by the large number of accidents involving the collapse of suspended ceilings. Non-standard fasteners for creating a suspended ceiling frame were studied and tested. Technical solutions from KNAUF catalogues were chosen as standard fasteners. The actual strength characteristics of the applied products for fasteners were determined. The measured characteristics were compared with official data from the manufacturers. The destructive loads and conditions of application of non-standard methods of fixing suspended ceilings and the possibility of their safe operation were evaluated. The costs of installing ceilings with non-standard fasteners were estimated. Recommendations were developed on eliminating defects in fasteners and on the use of non-standard fasteners for suspended ceilings.

Experimental and analytical study on performance of seismic sway braces for suspended piping systems

The severe damages to nonstructural components (NSCs) are frequently reported following earthquakes. Suspended piping systems are among the most common NSCs, since they are widely installed in modern buildings. As demonstrated by the failures reported after earthquakes, piping systems are often subjected to piping connection damage, or damage resulted from inadequate braces. Therefore, there is an increasing need to understand the seismic performance of widely used seismic sway braces for suspended piping systems. In the current study, a series of component-level tests were conducted to estimate the performance of seismic sway braces. The tested specimens were constructed from C-shaped square steel channel struts, vertical threaded rod, screw fastener, top connection, bottom connection, and pre-tightening bolt. The variables considered in these tests including installation distance from the floor slab to the bottom connection, the diagonal channel inclined angle, and the number of diagonal channels. The tested specimens were subjected to cyclic loading based on loading protocol suggested by FM1950. The experimental data were then utilized to develop fragility curves for seismic sway braces. In addition to the experimental tests, analytical models for seismic sway braces were developed and calibrated using the experimental data.

Evaluation of Different Capture Solutions for Ammonia Recovery in Suspended Gas Permeable Membrane Systems.

Gas permeable membranes (GPM) are a promising technology for the capture and recovery of ammonia (NH3). The work presented herein assessed the impact of the capture solution and temperature on NH3 recovery for suspended GPM systems, evaluating at a laboratory scale the performance of eight different trapping solutions (water and sulfuric, phosphoric, nitric, carbonic, carbonic, acetic, citric, and maleic acids) at 25 and 2 °C. At 25 °C, the highest NH3 capture efficiency was achieved using strong acids (87% and 77% for sulfuric and nitric acid, respectively), followed by citric and phosphoric acid (65%) and water (62%). However, a remarkable improvement was observed for phosphoric acid (+15%), citric acid (+16%), maleic acid (+22%), and water (+12%) when the capture solution was at 2 °C. The economic analysis showed that water would be the cheapest option at any working temperature, with costs of 2.13 and 2.52 €/g N (vs. 3.33 and 3.43 €/g N for sulfuric acid) in the winter and summer scenarios, respectively. As for phosphoric and citric acid, they could be promising NH3 trapping solutions in the winter months, with associated costs of 3.20 and 3.96 €/g N, respectively. Based on capture performance and economic and environmental considerations, the reported findings support that water, phosphoric acid, and citric acid can be viable alternatives to the strong acids commonly used as NH3 adsorbents in these systems.

Revealing the effect of biofilm formation in partial nitritation-anammox systems: Start-up, performance stability, and recovery

Successful application of partial nitritation-anammox (PNA) processes is currently and primarily associated with biofilm systems. Biofilm characteristics significantly influence start-up, performance stability, and recovery. Here, two PNA systems with and without carriers were implemented simultaneously for treating wastewater containing 50 mg-NH4/L. The performance characteristics of these two PNA systems were compared. Stable nitrogen removal efficiencies of 76.3 ± 2.8% and 72.9 ± 1.6% were obtained for suspended sludge and biofilm systems, respectively. The slow process of biofilm colonization resulted in a long start-up time in the biofilm system. Biofilm enrichment and protection conferred stable performance when exposed to aeration shock. The suspended sludge system displayed good elasticity during performance recovery after shock compared to the slow recovery in the biofilm system. Moreover, suitable control of dissolved oxygen could improve the activity and abundance of the functional microbes. This study provides new insights into the operation and control of PNA systems for treating mainstream wastewater.

Numerical seismic fragility analysis for suspended ceilings with various geometries

Damage to suspended ceiling systems have impeded the functionality of buildings after the recent seismic events. Several experimentally validated numerical models have been developed for these systems, but because of the limitations of the current modelling techniques our understanding of their seismic vulnerabilities has remained insufficient. This is mainly because these models have been developed based on a specific experimental setup and certain ceiling geometries. In addition, the lack of a numerical model that captures the seismic failure progression of ceiling systems has prevented performing reliable fragility analyses. Even if we assume that such a numerical model is available, the effort needed to model such a complicated system prohibits investigation of diverse design and geometric variations. In a novel approach, this study has advanced an automated approach for generating the analytical models. This paper introduces an automated workflow for generating the ceiling models of different geometries and design in the OpenSees platform. The seismic behavior of unbraced suspended ceiling systems with various aspect ratios is investigated, and their unique fragility curves are developed. The fragility curves are compared against those presented in the FEMA-P58, which showed close agreement. In addition, new sets of fragility curves were developed for the ceiling geometries other than those presented in FEMA-P58.

Residual palm kernel expeller as the support material and alimentation provider in enhancing attached microalgal growth for quality biodiesel production

Albeit the biodiesel production from suspended microalgal system has gained immense interests in recent years, the domineering limitation of being economically infeasible has hindered this technology from partaking into a large-scale operation. To curtail this issue, attached growth system had been introduced by various studies; however, those were still unable to alleviate the socio-economic challenges faced in commercializing the microalgal biomass production. Thus, this study had developed a novel approach in cultivating-cum-harvesting attached Chlorella vulgaris sp. microalgae, whilst using solid organic waste of palm kernel expeller (PKE) as the supporting and alimentation material for microalgal biofilm formation. The effects of three variables, namely, PKE dosage, light intensity, and photoperiod, were initially modelled and later optimized using Response Surface Methodology tool. The derived statistical models could predict the growth performances of attached microalgal biomass and lipid productivity. The optimum growing condition was attained at PKE dosage of 5.67 g/L, light intensity of 197 μmol/m2 s and photoperiod of 8 light and 16 dark hours/cycle, achieving the microalgal density and lipid content of 9.87 ± 0.05 g/g and 3.39 ± 0.28 g/g, respectively, with lipid productivity of 29.6 mg/L day. This optimum condition had led to the intensification of biodiesel quality with a high percentage of monounsaturated fatty acid, i.e., oleic acid (C18:1), encompassing 81.86% of total fatty acid methyl ester components. Given that the positive acquisition of PKE as an excellent supporting material in enhancing the microalgal density and lipid productivity that had resulted in the commercially viable biodiesel quality, this study served as a novel revolution in augmenting the microalgae and solid waste utilities for sustainable energy generation.

Microfabrication Bonding Process Optimization for a 3D Multi-Layer PDMS Suspended Microfluidics

Microfluidic systems have received increased attention due to their wide variety of applications, from chemical sensing to biological detection to medical analysis. Microfluidics used to be fabricated by using etching techniques that required cleanroom and aggressive chemicals. However, another microfluidic fabrication technique, namely, soft lithography, is less expensive and safer compared to former techniques. Polydimethylsiloxane (PDMS) has been widely employed as a fabrication material in microfluidics by using soft lithography as it is transparent, soft, bio-compatible, and inexpensive. In this study, a 3D multi-layer PDMS suspended microfluidics fabrication process using soft lithography is presented, along with its manufacturing issues that may deteriorate or compromise the microsystem’s test results. The main issues considered here are bonding strength and trapped air-bubbles, specifically in multi-layer PDMS microfluidics. In this paper, these two issues have been considered and resolved by optimizing curing temperature and air-vent channel integration to a microfluidic platform. Finally, the suspended microfluidic system has been tested in various experiments to prove its sensitivity to different fluids and flow rates.

Comparison of two advanced hybrid closed loop in a pediatric population with type 1 diabetes: a real-life observational study.

The Advanced Hybrid Closed Loop (AHCL) systems have provided the potential to ameliorate glucose control in children with Type 1 Diabetes. The aim of the present work was to compare metabolic control obtained with 2 AHCL systems (Medtronic 780G system and Tandem Control IQ system) in a pediatric real-life clinical context. It is an observational, real-life, monocentric study; thirty one children and adolescents (M:F = 15:16, age range 7.6-18years, mean age 13.05 ± 2.4years, Diabetes duration > 1year) with T1D, previously treated with Predictive Low Glucose Suspend (PLGS) systems and then upgraded to AHCL have been enrolled. CGM data of the last four weeks of "PLGS system" (PRE period) with the first four weeks of AHCL system (POST period) have been compared. For both AHCL systems, Medtronic 780G and Tandem Control IQ, respectively TIR at 4weeks significantly increased, from 65.7 to 70.5% (p < 0.01) and from 64.8 to 70.1% (p < 0.01). (p < 0.01). The comparison between CGM metrics of the 2 evaluated systems doesn't show difference at baseline (last four weeks of PLGS system) and after four weeks of AHCL use. To our knowledge, this study is the first real-life one comparing 2 AHCL systems in a pediatric population with T1D. It shows an improvement in glucose control when upgrading to AHCL. The comparison between the two AHCL systems did not show significant differences in the analyzed CGM metrics, meaning that the algorithms currently available are equally effective in promoting glucose control.

Experimental testing on nonstructural continuous plasterboard suspended ceiling systems under shake table-generated motions

Three different continuous plasterboard suspended ceiling systems were experimentally investigated through shake table-generated motions: (1) vertical strut ceiling system with all edges fixed, (2) vertical strut and lateral brace ceiling system with all edges free, and (3) vertical strut ceiling system with all edges free. Dynamic behavior and performance of these ceiling systems were evaluated to understand the effect of various boundary conditions and lateral force-resisting mechanisms at increasing intensity levels of input motion. All the ceiling systems performed well up to floor accelerations ranging from 1.4 to 1.6 g without any visible damage. However, under sinusoidal excitation at the natural frequency of the ceiling systems, the strut system with free boundaries proved vulnerable as it slipped from the perimeter channel leading to major damage. This suggests that the vertical strut system with free edges is vulnerable for multistory buildings located in any seismic zone due to its poor performance observed under large acceleration demands.

Hybrid Close-Loop Systems Versus Predictive Low-Glucose Suspend and Sensor-Augmented Pump Therapy in Patients With Type 1 Diabetes: A Single-Center Cohort Study.

IntroductionPredictive low-glucose suspend (PLGS) and hybrid closed-loop (HCL) systems may improve glucose control and quality of life in type 1 diabetic individuals. This is a cross-sectional, single-center study to compare the effect on metabolic control and glucose variability of PLGS and HCL systems as compared to standard sensor-augmented pump (SAP) therapy.MethodsWe retrospectively analyzed 136 adults (men/women 69/67, mean age 47.3 ± 13.9 years) with T1D on insulin pump therapy, divided accordingly to type of insulin pump system (group 1: SAP, 24 subjects; group 2: PLGS, 49 subjects; group 3: HCL, 63 subjects). The groups were matched for age, gender, years of disease, years of CSII use, and CGM wear time.ResultsThe analysis of CGM metrics, in the three groups, showed a statistically significant different percentage of time within the target range, defined as 70–180 mg/dl, with a higher percentage in group 3 and significantly less time spent in the hypoglycemic range in groups 2 and 3. The three groups were statistically different also for the glucose management indicator and coefficient of variation percentage, which were progressively lower moving from group 1 to group 3. In the HCL group, 52.4% of subjects reached a percentage of time passed in the euglycemic range above 70%, as compared to 32.7% in those with PLGS and 20.2% in those with SAP. A positive correlation between the higher percentage of TIR and the use of auto-mode was evident in the HCL group. Finally, the three groups did not show any statistical differences regarding the quality-of-life questionnaire, but there was a significant negative correlation between CV and perceived CSII-use convenience (r = -0.207, p = 0.043).ConclusionHCL systems were more effective in improving glucose control and in reducing the risk of hypoglycemia in patients with type 1 diabetes, thereby mitigating risk for acute and chronic complications and positively affecting diabetes technologies’ acceptance.

Predation of the crab Acanthocyclus albatrossis on seeds of the bivalve Mytilus chilensis under different environmental conditions: Importance of prey and predator size

Predation is one of the most important interactions in biology, playing a fundamental role in the ecology of populations and communities. In southern Chile, the mussel Mytilus chilensis supports a large aquaculture industry. This species cohabits with one of its predators, the crab Acanthocyclus albatrossis, both in wild bivalve beds and in suspended culture systems. In this investigation, we assessed the predator-prey interaction between these two species, addressing the following aspects: a) the vulnerability pattern of M. chilensis to predation by A. albatrossis; b) prey sizes that are free of predation (the refuge in size); c) the attack rate and d) the effects of temperature and salinity on predation by different-sized A. albatrossis crabs. The prey sizes most likely to be attacked were 7.5, 12 and 14 mm (valve length) respectively for the three predator size categories evaluated. The sizes of the mussels that are free of predation were > 12, > 18 and > 22 mm respectively for each predator size. The mean attack rate was affected by the size of M. chilensis, with the smallest prey (6–12 mm) exposed the highest predation pressure. Temperature exhibited a positive linear effect on the median attack rate only for crabs in the smallest size category; no pattern was observed for the effect of temperature on the other sizes of crabs. Salinity showed no evident effects on the median attack rate at any size category. Our results indicate that A. albatrossis could be an important predator of M. chilensis recruits in wild bivalve beds, and of seeds in suspended culture systems.

Dynamic Analysis of A Subsea Suspended Manifold Going Through Splash Zone During Installation

The subsea suspended manifold designed to replace the traditional foundation structure with the buoys is a new generation subsea production system that can be suspended at a certain height from the seafloor and rapidly recycled by its own buoyancy. Due to complex environmental conditions, its hydrodynamic performance in the splash zone is extremely important for the safety of the whole installation process. In this paper, the mathematical model for the dynamic analysis of the seawater ingress process of the single-layer pre-set horizontal cabin is proposed based on the different center of gravity positions of the buoy. Meanwhile, the theoretical analysis of fiber cable is divided into infinite differential units by the discretization method, and the formulae of the horizontal displacement of the subsea suspended manifold are presented. In addition, the simulations are carried out to verify the rules of the dynamic responses on the subsea suspended manifold system with the consideration of the environmental conditions in the South China Sea. Comparing with the calculated value of the mathematical model of the cabin water ingress, the error of the simulation result by use of FLUENT is about 5.47%. Furthermore, the wave height is greater than the current impact on the lowering manifold system and the azimuth angle of the installation vessel is aligned with the direction of the environmental load.

Shaking table test on a novel mega-frame suspended structural system

This paper designed a 1/20 scaled two-segment 19-story mega-frame suspended structure. The seismic behaviors of the structure equipped with viscous dampers (named damping suspended structure, DSS) or rigid connecting rods (named normal suspended structure, NSS) were studied and evaluated by a series of shaking table tests, where three seismic ground motions with two intensities were selected as input motions. Both acceleration and displacement responses of the primary and suspended structures were recorded. The results revealed that the mega-frame suspended system showed good seismic behaviors and viscous dampers could effectively improve its energy dissipation capacities. For DSS, the maximal acceleration and displacement reduction of suspended structures were 75.4% and 39.8% while those of the primary structure were 29.4% and 35.3% respectively. White noise tests showed all models were at the elastic stage under all cases. Evident relative displacements between the primary and subordinate structures were observed for DSS, in this case, the suspended floors were considered as the additional mass of the primary structure and the energy could be dissipated by the swing of suspended floors. The energy dissipation mechanism of DSS was theoretically analyzed while the effect of connection forms on vibration reduction was discussed.

Substrate effect on growth and survival of the rock oyster Striostrea prismatica (Gray, 1825) cultured in suspended systems in two different ecosystems

The interest in developing a more diverse mollusk aquaculture in the tropical eastern Pacific has increased in recent years. In this region, the rock oyster Striostrea prismatica is being extracted and consumed massively. The species lives attached to large rocks, which offer firmness and stability in their high-energy environment. For aquacultural research purposes, we seek to simulate those natural conditions through artificial fixation of spat with an epoxy adhesive. Spat (initially metamorphosed on pieces of shell of 0.5 mm2) with a size of 14.00 ± 1.85 mm in dorso-ventral length were artificially fixed on substrates: shells, stones, and plastics. In addition, individual non substrate animals from de same cohort were also grown and used as a control. The performance of these spat in suspended culture at sea and estuarine area, together with the environmental variables of each growing site were registered. In the two culture sites and for all treatments, the animals were confined in black polypropylene culture systems. After 12 months, artificially fixed animals (regardless of substrate) had significantly higher lengths (≈80 mm) and dry tissue masses (≈3 g) compared to non-substrate animals (≈46 mm and ≈0.90 g, respectively). ANOVA did not show significant differences between the sites (blocks) for survival, shell and tissue increases, despite the different environmental conditions characteristic of both areas. Therefore, our study shows that the strategy of artificially fixing the spat is a necessary activity to ensure the good performance of S. prismatica for its cultivation in the sea or in estuarine areas.

Research on Vibration Characteristic Analysis of Magnetic Suspended Dual-Rotor System with Fixed-Point Rubbing

Due to the elimination of wear and lubrication system and effective solution to the vibration control issue, magnetic suspended dual-rotor system (MSDS) offers the possibility to significantly enhance the performance of aero-engines. However, research on MSDS vibration characteristics under fixed-point rubbing with the consideration of nonlinear support characteristics of active magnetic bearing (AMB) has rarely been addressed. In this research, an improved EF model of AMB is proposed by equivalent magnetic circuit method and verified by finite element model. Then, the Lankarani-Nikravesh model is employed to describe the impact force during rubbing process. On this basis, the rubbing dynamic model is established by finite element method and verified by comparing with the experimental results in literature. Finally, the MSDS vibration characteristics are explored, and some interesting phenomena are found. Fixed-point rubbing will cause abundant frequency components equally spaced around the combined frequency components of rotor rotational speeds at different frequency intervals. Due to the stimulation of the AMB nonlinear EF, the fractional frequency component of MSDS second-order critical speed emerges in a certain speed range and implies potential instability of the system, and the rotational speed corresponding to the initial appearance of this frequency component will decrease when fixed-point rubbing occurs. With the decrease of proportional coefficient and the increase of differential coefficient, the maximum normal impact force in the rubbing process decreases.

Development of Vibration Control Structure on Suspended Ceiling Using Pulley Mechanism

A suspended ceiling system (SCS) is one of the most fragile and non-structural elements during earthquakes. However, effective seismic protection technologies for enhancing the suspended ceiling system have not been developed other than the steel bracing system. An innovative passive vibration control system is proposed in this paper, which equipped a damper-employed pulley amplification mechanism into the indirect suspended ceiling system, named the pulley–damper ceiling system (PDCS). Theoretical formulation and the detailed information on the system were presented first. In addition, a new rotational damper composition consisting of a non-linear viscous damper was developed to follow the large wire-cable stroke. Six types of the full-scale ceiling specimens of a 15.6-square meter area with different configurations were constructed for the preliminary experiments to evaluate the seismic performance and feasibility of PDCS under simulated earthquake motions. The comparative results of the shake table test demonstrated that the application of PDCS is capable of controlling both displacement and acceleration of the ceiling panels. This study also presents the nonlinear time history analyses by modeling a wire-cable as an equivalent truss element to transmit the relative displacement of the ceiling system to the damper. The analytical model accurately simulated the dynamic behavior of PDCS.

Automated Insulin Delivery with SGLT2i Combination Therapy in Type 1 Diabetes

Background:Use of sodium-glucose cotransporter 2 inhibitors (SGLT2i) as adjunct therapy to insulin in type 1 diabetes (T1D) has been previously studied. In this study, we present data from the first free-living trial combining low-dose SGLT2i with commercial automated insulin delivery (AID) or predictive low glucose suspend (PLGS) systems.Methods:In an 8-week, randomized, controlled crossover trial, adults with T1D received 5 mg/day empagliflozin (EMPA) or no drug (NOEMPA) as adjunct to insulin therapy. Participants were also randomized to sequential orders of AID (Control-IQ) and PLGS (Basal-IQ) systems for 4 and 2 weeks, respectively. The primary endpoint was percent time-in-range (TIR) 70–180 mg/dL during daytime (7:00–23:00 h) while on AID (NCT04201496).Findings:A total of 39 subjects were enrolled, 35 were randomized, 34 (EMPA; n = 18 and NOEMPA n = 16) were analyzed according to the intention-to-treat principle, and 32 (EMPA; n = 16 and NOEMPA n = 16) completed the trial. On AID, EMPA versus NOEMPA had higher daytime TIR 81% versus 71% with a mean estimated difference of +9.9% (confidence interval [95% CI] 0.6–19.1); p = 0.04. On PLGS, the EMPA versus NOEMPA daytime TIR was 80% versus 63%, mean estimated difference of +16.5% (95% CI 7.3–25.7); p < 0.001. One subject on SGLT2i and AID had one episode of diabetic ketoacidosis with nonfunctioning insulin pump infusion site occlusion contributory.Interpretation:In an 8-week outpatient study, addition of 5 mg daily empagliflozin to commercially available AID or PLGS systems significantly improved daytime glucose control in individuals with T1D, without increased hypoglycemia risk. However, the risk of ketosis and ketoacidosis remains. Therefore, future studies with SGLT2i will need modifications to closed-loop control algorithms to enhance safety.