Blood clam or blood cockle (Anadara granosa) is a clam species with high calcium carbonate (CaCO3) and chitin content; these compounds are commonly used in coagulation water treatment. This study examined the capacity of blood cockle shells (BCS) as an innovative natural coagulant in the form of unmodified powder (BCSP) and chitosan extracted from the shells (BCSC) to reduce TSS and turbidity of well-water. SEM and FTIR analysis were conducted to analyse the characteristics of the media. The coagulant dose, pH of the water sample, and settling time were investigated using a jar test experiment to determine the optimum condition for each experimental system. Rapid mixing (1 min at 120 rpm) was followed by slow mixing (10 min at 60 rpm), followed by settling times ranging from 10 to 30 min. The optimum settling time was 30 min, after which 76% TSS and 76% turbidity were removed using 75 mg/l of BCSP at pH 4. The tests with BCSC resulted in 80% TSS and 81% turbidity removal with 200 mg/l of BCSC at pH 5 and a settling time of 30 min. The results were compared to the performance of alum (Al2(SO4)3·18H2O), a commercial chemical coagulant. Under similar dosage (200 mg/L) and pH (= 6) conditions, alum reduced turbidity and TSS by 95% and 97%, respectively. These results indicate that blood cockle shell-based coagulant is a promising environmental-friendly material that can compete and possibly replace conventional chemical coagulants in water treatment systems.