The article provides an overview of various indices/indicators (Vogt, Parker, CIA, CIW, PIA, MIA, etc.) used in the study of weathering profiles/crusts and reconstruction of paleoclimatic environments of sedimentary sequence accumulation. Their possibilities are demonstrated by the example of Vendian-Lower Cambrian terrigenous deposits of Podolsk Transnistria (southwestern slope of the Ukrainian Shield). The distribution of the ba1 index values in this section indicates the presence of the material most transformed by the processes of chemical weathering in the mudstones of the Nagoryany Formation, the lower part of the Danylivka and the middle part of the Studenytsya formations. For mudstones of the Danylivka–Zbruch interval, the HM values are close to the HMPAAS. For rocks of the Yaryshiv–Nagoryany interval, the HM values are slightly higher, and for mudstones in the lower part of the Yaryshiv Formation, they are comparable to those inherent in continental clays of a hot tropical climate. The average SA index for mudstones of the entire section is 5.6 ± ± 0.7. Mudstones of the Hrushka–Nagoryany interval, where SA SAPAAS, are composed of more weathered material. The WIP values in the mudstones of the Mohyliv and Yaryshiv formations, as well as in the upper part of the Zbruch Formation, correspond to the interval of their values between PAAS and the average Archean granite. Clay rocks of other formations have WIP ≤ WIPPAAS values. The average CIA value for mudstones is 71 ± 4, which practically corresponds to the CIA value (70), which separates the sediments of cold/arid and warm/humid climates. Variations in the CIW index along the section are symbate with variations in the CIA. The vast majority of mudstones are characterized by PIA PIAPAAS values. The average CPA value is 91 ± 4, which is also typical for PAAS. The above and other data show that on the basis of a “direct” interpretation of the values of various indices of chemical weathering inherent in fine-grained clastic rocks, the paleoclimate that existed in the Vendian‒Early Cambrian on the territory of Podolsk Transnistria was rather moderate or warm humid. Comparison of the CIA values of mudstones with the values of this indicator for the particulate suspended matter of modern rivers suggests that the climate in the Vendian‒Early Cambrian resembled dry and humid subtropical or dry tropical with elements of humid.