Objective: To describe the prevalence and incidence of suspected COVID-19 cases confirmed by PCR at Medical Center ISSEMyM Toluca from March 2019 to December 2022. Materials and Methods: 3226 PCR tests for suspected COVID-19 cases were analyzed to obtain epidemiological and demographic data of the population, descriptive and inferential statistics analyses were carried out to find differences between population parameters. Results: No differences between female and male respect to COVID-19 positivity were found (p-value = 0.9302). Age mean was 49 years old and the probability to get COVID-19 increase with age (p-value = 0.000). Hospitalization was the medical service with more frequency in patients with COVID-19 positive. Conclusion: Age but no gender is a risk factor hospitalization due COVID-19., nonetheless vaccination appear to an efficient method to prevent hospitalization. Moreover, the dynamic pandemic in Mexico is no homogeneous across the territory.