Retinoblastoma Survival Research Articles

Impact of socioeconomic disparities on cause-specific survival of retinoblastoma

Retinoblastoma (RB) is a rare disease of infancy and early childhood. This study investigated the effects of socioeconomic factors on the cause-specific survival of RB. Data from patients diagnosed with RB between 1973 and 2009 were obtained from the Surveillance, Epidemiology and End Results (SEER) database. The study included 1,456 patients with a the mean follow-up time (SD) of 128.75 (113.74) months and a mean age (SD) of 1.4 (2.6) years. This study analyzed socioeconomic, staging and treatment factors available in the SEER database for RB. Kaplan-Meier analysis was used to analyze time-to-failure data. The two-sample Kolmogorov-Smirnov test was used for univariate analysis and the Cox proportional hazards model was used for multivariate analysis. The area under the receiver operating characteristic (ROC) curve was computed for predictors. SEER stage was the most significant predictive pretreatment factor. The identified socioeconomic barriers included ethnicity and rural-urban residence status that led to a 3% decrease in RB cause-specific survival. Thus, eliminating barriers to treatment is crucial for reducing the outcome disparities.

Strategies to manage retinoblastoma in developing countries

Survival of retinoblastoma is >90% in developed countries but there are significant differences with developing countries in stage at presentation, available treatment options, family compliance, and survival. In low-income countries (LICs), children present with advanced disease, and the reasons are socioeconomic and cultural. In middle-income countries (MICs), survival rates are better (>70%), but there is a high prevalence of microscopically disseminated extraocular disease. Programs for eye preservation have been developed, but toxicity-related mortality is higher. Although effective treatment of microscopically extraocular disease improved the outcome, worldwide survival will be increased only by earlier diagnosis and better treatment adherence.

Survival of retinoblastoma in less-developed countries impact of socioeconomic and health-related indicators

BackgroundThe survival of retinoblastoma in less-developed countries (LDCs) and the impact of socioeconomic variables on survival are not widely available in the literature.MethodsA systematic review of publications from LDCs was...

Survival with retinoblastoma in the USA: 1975–2004

Background:The purpose of this study was to determine the survival of retinoblastoma in the USA over a 30-year period from 1975 to 2004 using a systematic review of existing databases.Methods:Nine...

Incidence and survival of retinoblastoma in the Netherlands: a register based study 1862–1995

AIMThe aim of this study was to determine the (time trends in) incidence and survival of hereditary (familial and sporadic) and non-hereditary retinoblastoma for male and female patients born in...