Survival In Cervical Carcinoma Research Articles

Cytologic Screening for Gynecologic Cancer

In the past 30 years there has been no improvement in the five-year survival rate for endometrial carcinoma. Any change comparable to improved survival in cervical carcinoma will be accomplished only by similar detection of the early asymptomatic and precursor lesions of endometrial carcinoma. Reasons why the conventional Pap smear taken today has only a 25% to 50% screening accuracy for endometrial carcinoma are explained along with methods to improve these percentages. With our technic, endometrial aspiration cytology has the capabilities of screening for varying stages of endometrial hyperplasia that are considered precursors of endometrial carcinoma, as well as an 85% accuracy rate for screening detection of established endometrial carcinoma. These technics and methods, along with accompanying photographs and photomicrographs of representative cytologic and histologic specimens of varying representative lesions are shown.

Microscopic grading, clinical staging, and survival in cervical carcinoma

The cervical biopsies of 131 patients with squamous cell carcinoma of the uterine cervix were reviewed, graded microscopically, compared with the clinical staging, and both correlated with five year survival and no five year survival.Slightly fewer subjects with low microscopic grades of malignancy survived five years than did not survive. Considerably fewer individuals with higher grades of malignancy survived than did not survive. Almost equal numbers of patients with early clinical stages of disease survived as did not survive. Many more patients with late clinical staging did not survive than did. There appeared to be a better correlation with survival and no survival with higher grades of malignancy and later clinical staging than with either lower grades or early clinical staging.A better prognostic index combines both clinical staging and microscopic grading.