Short-form Survey Research Articles

Impact of left atrial myopathy and post-ablation remodeling on quality of life: a DECAAF II sub-analysis.

Atrial fibrillation (AF) is associated with adverseremodeling of the left atrium (LA). The impact of the extent of atrial myopathy and post-ablation remodeling on quality-of-life (QoL) outcomes has notbeen studied. The aim of our study was to investigate the association between atrial myopathy and post-ablation remodeling on quality-of-life outcomes in patients with persistent AF. We conducted an analysis of DECAAF II participants who underwent late-gadolinium enhancement MRI (LGE-MRI) before and after AF ablation. We assessedatrial myopathy and post-ablation atrial remodeling, scar formation, and fibrosis coverage with ablation. QoL metrics were assessed using the Short Form Survey (SF-36) and Atrial Fibrillation Severity Scale (AFSS). Uni- and multivariable regression models were developed for this analysis. Six hundred thirteen patients with persistent AF were included in our analyses. At baseline, AFSS burden and total AFSS score were 18.94 ± 7.35 and 12.24 ± 8.17, respectively. Following ablation, all QoL and AFSS metrics improved in both the pulmonary vein isolation (PVI) and MRI-guided fibrosis ablation groups. On average, one unit of post-ablation reduction in left atrial volume index (LAVI) was associated with an improvement of 0.085 in total AFSS score (p = 0.001), 0.01 in shortness of breath with activity (p < 0.001), 0.15 in AF burden (p < 0.001), - 0.016 in global well-being (p = 0.018), 0.519 in health change (p < 0.001), 0.19 in vitality (vitality (p = 0.01), and 0.27 in physical functioning (p = 0.001). Baseline fibrosis and residual fibrosis post-ablation were associated with improved vitality and general health. Atrial myopathy and post-ablation atrial remodeling significantly impact QoL in patients with persistent AF undergoing ablation.

Physical Health Views Among Individuals Experiencing Mental Illness: A Mixed-Methods Study of Self-Reported Health and Contributing Factors.

Severe mental illness is linked to poor physical health and shorter life expectancy, yet research on how individuals experiencing mental illness view and on improve their physical health is limited. This study investigates the perceptions of individuals experiencing mental illness regarding their physical health, utilising a mixed-methods approach. Phase I involved quantitative and qualitative data from an online Qualtrics survey, which included the 12-item Short Form (SF-12) survey to measure participants' quality of life and assess self-reported physical and mental health. Key findings from Phase I revealed significant relationships between lower Physical Component Summary (PCS) scores and factors such as the frequency of GP visits. Additionally, exercise preferences were found to significantly impact Mental Component Summary (MCS) scores, with individuals who preferred a mix of exercise settings reporting higher MCS scores compared to those who exercised alone or with a training partner. Phase II explored these findings further through semi-structured interviews, where participants discussed themes including physical health perceptions, the role of medication and the importance of the general practitioner relationship. Thematic analysis revealed five main barriers to improving physical health: accessibility and availability of services, motivation, staff attitudes, medication side effects and the experience of diagnostic overshadowing. Participants reported viewing physical and mental health as interconnected and expressed a desire for more collaborative care. The results suggest that strengthening the relationship with GPs and increasing awareness of medication side effects may improve physical health outcomes for individuals experiencing mental illness. Mental health nurses can play a pivotal role in enhancing physical health outcomes by monitoring, supporting health-improving strategies and facilitating access to primary care services.

Clinical value analysis of integrated care model in reducing bleeding and complications during Da Vinci robot-assisted urology.

This study aims to explore the effect of integrated care mode on patients in Da Vinci robot-assisted urology surgery and provide a new nursing scheme for clinic. A total of 93 patients from August 2022 to March 2024 were selected and divided into intervention group (43 cases) and control group (50 cases). The operation time, blood loss, first postoperative exhaust time, time to get out of bed, pain score (visual analog scale), psychological status (self-rating anxiety scale and self-rating depression scale), quality of life score (36-Item Short Form Survey), catheter retention time, patient satisfaction, incision healing, incidence of urinary system infection, nutritional status, and complication rate were compared between the 2 groups. There were no significant differences in baseline data and operative time between the 2 groups (P > .05), but the amount of intraoperative blood loss in the intervention group (250.32 ± 50.23) mL was less than that in the control group (320.56 ± 65.34) mL (P < .05). The first postoperative exhaust time and getting out of bed time in the intervention group were shorter than those in the control group (P < .05), and the pain visual analog scale score was lower than that in the control group (P < .05). The scores of self-rating anxiety scale and self-rating depression scale of mental state were better than those of the control group (P < .05), and the scores of quality of life were higher (P < .05). The retention time of catheter was shorter than that of the control group (P < .05), the patient satisfaction was 93.02% higher than that of the control group 78.00% (P < .05), and the grade A incision healing rate was 90.70% higher than that of the control group 76.00% (P < .05). The incidence of urinary system infection (4.65%) was lower than that of the control group (16.00%) (P < .05), the changes of serum albumin level and body weight were lower than that of the control group (P < .05), and the complication rate of 6.98% was lower than that of the control group (22.00%) (P < .05). Although the integrated medical care model did not significantly shorten the operation time, it was beneficial to the postoperative recovery of patients in many aspects.

P-1325. Quality of Life and Severity of Symptoms in 1-year Follow Up of Patients Presenting with Acute Babesiosis: A Prospective Cohort Study with Validated Questionnaire

Abstract Background Tick-borne diseases are a growing public health concern in the US, particularly in New York. Babesia microti, a parasitic blood-borne piroplasm, causes the disease Babesiosis in humans. The aim of this prospective cohort study is to examine the frequency and severity of symptoms as well as the Quality of Life (QOL) after treatment in patients with Babesiosis (immunocompetent vs. immunocompromised) at up to 1-year of follow up.Table 1:Estimated ratio of VAS total score across time points within each immune group based on linear mixed effect model Methods Acute babesiosis adult patients with peripheral blood smear positive for Babesia (confirmed B. microti by PCR) were enrolled into a 1-year follow up cohort study. Twelve symptoms were evaluated by a Visual Analogue Scale (VAS) scoring system on presentation, and at 1, 6 and 12 months; higher scores represented worse status. QOL was assessed through a 36-Item Short Form Survey (SF-36) which taps eight health concepts; higher scores represented better status. Linear mixed-effects models were constructed to examine the change in VAS and SF-36 scores.Table 2:Estimated ratio of SF-36 concept score between immune groups at each time point based on linear mixed effect models Results Out of a total of 38 enrolled, 33 patients (mean age 60 ± 19 years; female 30.3%) completed their initial VAS. At baseline, fatigue had the highest frequency among all symptoms, 96.15% and 100%, in the immunocompetent and immunocompromised cohorts, respectively. Median VAS scores at baseline were 35.5 (immunocompetent, n=26) and 22.0 (immunocompromised, n=7). Compared to baseline, VAS total symptom scores significantly decreased at 1 month for the immunocompetent (n=20, p &amp;lt; .0001) and immunocompromised groups (n=5, p=0.04). For SF-36 concepts, 29 patients completed the initial survey (immunocompromised, n=6). Within QOL, concept scores for physical functioning and general health were significantly increased at 6 months follow up in both cohorts. Nonetheless, in comparison to the immunocompetent group, the immunocompromised group had significantly lower scores, or worsened QOL, in general health concept at months 1 (p=0.04) and 6 (p=0.0004). Conclusion VAS scores significantly decreased for both groups, but more prominently for the immunocompetent group, and a difference in quality of life was identified. Immunocompromised patients had more prolonged symptoms and worsened quality of life during the 1-year follow up compared to healthy individuals. Disclosures All Authors: No reported disclosures

Abstract B033: Long-Term quality of life and hearing preservation after stereotactic radiosurgery for vestibular schwannoma

Abstract Purpose/Objective(s): The aim of this study is to evaluate the long-term quality of life (QOL) and hearing preservation outcomes following definitive single-fraction Gamma Knife stereotactic radiosurgery (GKSRS) for vestibular schwannoma (VS). Materials/Methods: Baseline and follow-up QOL and audiogram data were collected from our prospectively maintained institutional database of VS patients treated with single-fraction GKSRS from 2006 to 2023. QOL metrics included the Hearing Handicap Inventory (HHI), Dizziness Handicap Inventory (DHI), Tinnitus Handicap Inventory (THI), and the 36-Item Short-Form Survey (SF-36). Serviceable hearing preservation was classified according to the Gardner-Robertson scale using pure-tone average (PTA) and speech discrimination (SD). Linear mixed-effects models were constructed for each QOL metric over time. Results: A total of 388 patients (median age 61 years) were included with a median follow-up of 48 months. Median tumor size was 1.6 cm (interquartile range [IQR] 1.1-2.1 cm), with a median tumor volume of 0.6 cc (IQR 0.2-1.6 cc). Most patients received a prescription marginal dose of 12.5 Gy with a median cochlear mean dose of 2.7 Gy (IQR 1.9-3.8 Gy). Baseline median HHI, DHI, THI, and SF-36 scores were 28, 12, 12, and 73 respectively. Linear mixed-effects analyses indicated no statistically significant decline in any of these QOL metrics up to 7 years after GKSRS. Of patients with serviceable hearing at baseline, hearing preservation was maintained in 79% at 12 months, 67% at 2 years, and 68% at 3 years. Conclusion: GKSRS preserves long-term patient quality of life and serviceable hearing in the definitive management of VS. Citation Format: Shayzal Siddiqui, Joseph S. Lee, Julia Abbo, Jessica Cummings, Avi Desai, Inga S. Grills, Peter Y. Chen, Jeffrey Jacob, Kuei C. Lee. Long-Term quality of life and hearing preservation after stereotactic radiosurgery for vestibular schwannoma. [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Translating Targeted Therapies in Combination with Radiotherapy; 2025 Jan 26-29; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(2_Suppl):Abstract nr B033.

Qualitative analysis of pain impact in adult patients with X-linked hypophosphatemia

Abstract We previously reported pain as a predominant finding in adult patients with XLH. This study explored health-related quality-of-life using the 36-item Short Form survey instrument (SF-36v1) and pain experiences of adults with X-linked hypophosphatemia (XLH) through qualitative analysis of interviews with 15 patients (11 females, 4 males). Age-adjusted differences using SF-36 were lower than the general population in all domains of health-related quality of life, with significant differences notably related to physical function and pain. Ten themes emerged from semi-structured interviews: 1) Chronic and Variable Pain: Patients reported persistent pain of varying intensity and location; 2) Impact on Mobility and Daily Life: Pain severely restricted daily activities, affecting lifestyle, employment, and independence; 3) Pain Management: Patients used medications, physical therapy, lifestyle changes, alternative therapies, and assistive devices; 4) Healthcare and Accessibility Challenges: Access to appropriate care and treatments was limited by insurance issues and healthcare providers’ lack of XLH knowledge; 5) Emotional and Psychological Impact: Chronic pain and limitations led to social isolation, depression, and emotional burden; 6) Desire for Improved Information and Support: Patients sought better information, treatment, and community support; 7) Challenges with Physical Inactivity: Staying active was essential but difficult, as inactivity worsened pain; 8) Navigating Healthcare Services: Accessing therapy and insurance was often challenging; 9) Long-term Outlook and Concerns: Patients worried about disease progression and future health; and 10) Advocacy and Awareness: Increased public and medical awareness was needed to improve care. Although pain is not a universal experience within this population, it is a significant issue for many individuals with XLH. These data illustrate the profound impact of XLH on multiple life aspects underscoring the need for effective pain management strategies, better healthcare accessibility, supportive tools, and a more knowledgeable medical community to improve quality of life. Insights from this study will guide the development of a digital pain self-management intervention tailored to XLH patients to address these needs.

P0719 The SAPHIR study: Assessment of Fresenius Kabi adalimumab biosimilar persistence in patients with inflammatory chronic diseases: Descriptive analysis of patients baseline characteristics

Abstract Background Biosimilar treatment initiation is based on a shared decision-making process, in which the patient’s acceptability to the treatment plays a major role. Indeed, negative perception of the biosimilar by the patient can generate a nocebo effect, which interferes with treatment results, leading to subjective worsening of the disease or poor tolerability. The SAPHIR study aimed to evaluate baseline patients’ characteristics predictive of biosimilar treatment persistence. Methods The SAPHIR study is a prospective, multicentre, observational cohort study. All patients with inflammatory rheumatic diseases and inflammatory bowel diseases were included after initiating treatment with Idacio® (adalimumab biosimilar) and were to be followed over a period of one year with assessments at 1, 6 and 12 months. We present here the patients baseline characteristics and their acceptability to treatment. Results Of the 582 patients enrolled, 18 presented a protocol deviation and were not analysed. The 564 patients analysed were divided into two groups based on the circumstances of the Adalimumab biosimilar prescription: the "initiation" group (n=318) not previously treated with biotherapy and the "switch" group (n=246) previously treated with originator adalimumab. Disease severity was assessed globally on a Likert scale. According to this evaluation, 61% (n=185) of patients in the "initiation" group versus 10% (n=25) in the "switch" group were considered markedly or severely ill. Baseline data from these patients are summarised in Table 1. Patients were questioned about chronic treatment in general: 38% (n=61) of patients in the "initiation" group and 13.5% (n=25) in the "switch" group do not know if their medications are effective or even doubt their benefit. The perception of the biosimilar was assessed by a serie of affirmations (self-completion questionnaire on the acceptability of switching to a biosimilar), summarised in Table 2. Conclusion Biosimilars still meet with reluctance from patients. This situation seems linked to a lack of information on the concept of biosimilarity. Numerous guidelines have been published to promote and facilitate the transition from biotherapy to its biosimilar. These preliminary results show that difficulties with treatment acceptability also exist and seem more pronounced in patients initiating biological treatment with a biosimilar. Table 1: Baseline data: BMI, Body Mass Index; SF-12, 12-Items Short Form Survey; HAD Scale, Hospital Anxiety and Depression Scale. Table 2: Perception of the biosimilar by the patient

P0321 Early improvement of mental health is associated with long-term disease remission in Ulcerative Colitis

Abstract Background Emerging evidence underscore the critical role of mental health in managing ulcerative colitis. However, the potential impact of early mental health improvement on long-term therapeutic outcomes remains poorly understood. This study aimed to explore the association between early mental health improvements and long-term disease remission. Methods This was a post hoc analysis using data from the SELECTION trial (NCT02914522) involving 381 patients treated with filgotinib. Mental health was assessed using the mental health subscale of the 36-item Short-Form Survey. Endoscopic, clinical, and histologic outcomes were assessed at week 58. Multivariable logistic regression was used to calculate adjusted odds ratios (aOR) with 95% confidence intervals (95% CI). Receiver operating characteristic curves, combined with bootstrap resampling, were employed to determine the mental health response threshold. Results Early mental health improvements at week 10 were significantly associated with disease remission at week 58. After adjusting for potential confounders, the aOR of mental health improvements was 1.03 (95% CI: 1.00–1.06) for endoscopic remission, 1.03 (95% CI: 1.01–1.05) for clinical remission, 1.03 (95% CI: 1.01–1.05) for histologic remission, and 1.04 (95% CI: 1.01–1.07) for disease clearance at week 58. Patients who exhibited a mental health response at week 10 (defined as an increase in the mental health subscale score of ≥7.85) were more likely to achieve long-term endoscopic remission (aOR 2.67, 95% CI: 1.43–5.25), clinical remission (aOR 1.91, 95% CI: 1.22–2.99), histologic remission (aOR 1.98, 95% CI: 1.27–3.12), and disease clearance (aOR 3.48, 95% CI: 1.74–7.50). Additionally, incorporating mental health response assessment along with clinical remission significantly enhanced outcome predictions. Specifically, patients with only clinical remission at week 10 were approximately half as likely to achieve week-58 endoscopic remission (aOR 0.45, 95% CI: 0.21–0.91) compared to those who attained both mental health response and clinical remission. Conclusion Early mental health improvements independently predicted long-term disease remission in ulcerative colitis. Integrating mental health assessments into the management strategies may provide valuable insights beyond physical symptoms.

Firearm injury survivors report extreme high risk for poor physical and mental health outcomes early after hospital discharge necessitating multidisciplinary care

BackgroundUp to 20–40% of survivors of any traumatic injury develop post-traumatic stress disorder (PTSD) or depression after injury. Firearm injury survivors may be at even higher risk for adverse outcomes....

Mid- to Long-Term Outcomes of Two-Stage Revision Arthroplasty for Periprosthetic Joint Infection of the Shoulder.

Background/Objectives: Periprosthetic joint infection (PJI) after shoulder arthroplasty is often treated with a two-stage approach, but the data on the mid- to long-term outcomes remain scarce. This study aimed to evaluate the clinical outcomes of two-stage revision arthroplasty for shoulder PJI with a minimum follow-up of five years. Methods: This retrospective study identified 59 shoulders in 58 patients who underwent the first stage of a two-stage revision arthroplasty for shoulder PJI at our institution between 2007 and 2018. Of these, 29 shoulders in 29 patients (49.2%) did not undergo reimplantation or the patient passed away before reaching five years of follow-up. The remaining 30 shoulders in 29 patients were included in the study. The clinical assessments included the active range of motion, the visual analogue scale (VAS) for pain, the Subjective Shoulder Value (SSV), the Constant Score (CS), and the 12-Item Short Form Survey (SF-12), supplemented by detailed clinical and radiological evaluations. Results: The mean age of the 29 patients was 75.9 ± 10.4 years. The average follow-up duration was 8.3 ± 2.8 years. The most common indications for primary shoulder arthroplasty were primary osteoarthritis (n = 12, 40%) and fractures (n = 12, 40%). At the first stage, nine cases (30%) showed negative cultures, while C. acnes and S. epidermidis were each identified in eight cases (26.7%). Four shoulders (13.3%) experienced recurrent infections. At the follow-up, the mean abduction was 86 ± 48.1°, the mean forward flexion was 97.8 ± 50.1°, the mean external rotation was 20.5 ± 19.9°, and the internal rotation reached the lumbosacral region. The mean VAS pain score was 1.5 ± 2.1, the mean SSV was 51.8 ± 28.4%, the mean CS was 54.6 ± 21.0, and the mean SF-12 was 81.0 ± 16.0. Conclusions: Two-stage revision arthroplasty for shoulder PJI results in satisfactory subjective and objective outcomes, with a low overall reinfection rate. However, the high rates of mortality and failure to reimplant must be carefully considered when managing expectations in this challenging cohort.

Assessment of Quality of Life and Psychological Well-Being in Italian Adult Subjects with Prader-Willi Syndrome Using the Health Survey Short Form and the Psychological General Well-Being Index Questionnaires.

Background/Objectives: Prader-Willi syndrome (PWS) is a rare, genetically determined neurodevelopmental disorder. Individuals with PWS face numerous challenges that significantly impact their psychological well-being and quality of life, ultimately limiting their personal and social functioning. This study aimed to evaluate the quality of life and psychological well-being in a sample of Italian adult patients with PWS compared to an age-matched control group of normal-weight Italian individuals. Methods: Thirty patients with PWS (11 men and 19 women; mean age ± SD: 36.4 ± 10.31 years; mean Body Mass Index (BMI: 35.7 ± 8.92 kg/m2) and thirty Italian adult individuals from the general population (5 men and 25 women; mean age ± SD: 32.1 ± 6.86 years; mean Body Mass Index (BMI: 21.8 ± 2.90 kg/m2) were studied. Quality of life and well-being were assessed using the Italian versions of the 36-item Health Survey Short Form and the Psychological General Well-Being Index. Results: Normal-weight subjects scored significantly higher than PWS patients on the physical health (p < 0.001) and social functioning (p = 0.047) subscales of the SF-36. Conversely, PWS patients scored higher on the vitality subscale (p < 0.001). Similarly, the vitality subscale of the PGWBI was significantly higher in PWS patients than in controls (p = 0.010), whereas the Self-Control subscale of the PGWBI was higher in controls compared to PWS patients, albeit not statistically significant (p = 0.057). Discussion: Patients with PWS exhibited impairments in various aspects of quality of life and psychological well-being, including physical, behavioral, and social domains. However, the higher vitality scores observed in PWS patients suggest a preserved dimension of their psychological well-being. Conclusions: These findings enhance the understanding of the psychological condition of patients with PWS and provide valuable insights for improving multidisciplinary psychological treatment approaches for these individuals.

Work-related Musculoskeletal Disorders (WMSDs) and Quality of Life (QoL) among the construction workers in the United Arab Emirates.

Background The United Arab Emirates (UAE) construction industry has rapidly expanded, but construction work, by its nature, poses a high risk of work-related musculoskeletal disorders (WMSDs). These disorders significantly impact quality of life (QoL) and productivity and lead to disability and absenteeism. Aims and Objectives The study aims to determine the prevalence of WMSDs among UAE construction workers using the Nordic Musculoskeletal Questionnaire (NMQ) and assess their QoL using the Short-Form (SF-36) survey. Additionally, it aims to explore factors associated with WMSDs and QoL among construction workers in the United Arab Emirates. Methods This study is a cross-sectional, survey-based design conducted from July 2023 to May 2024 in the United Arab Emirates. The study included male construction workers aged 18-50 with at least 1 year of experience. Participants were recruited using a combination of convenience and purposive sampling methods. The data were collected via paper-based forms using the SF-36 and NMQ questionnaires. The study instruments were chosen after reviewing relevant literature to ensure minimal measurement bias. Statistical methods included descriptive statistics, tests for normality, and Pearson’s correlation test with a significance level of p &lt;0.05. Results A total of 346 construction workers were accessed and the study found an 81.8% 12-month WMSD prevalence, most commonly affecting the lower back (44.8%), neck (45.1%), and shoulders (37.9%). Additionally, 70.5% reported pain-related limitations, and 63.6% experienced pain in the past week. SF-36 scores were lowest for role limitations due to physical health (30.33) and emotional problems (33.43), with an overall mean of 52.27 out of 100. Conclusion The study found a high prevalence of WMSD in construction workers and moderate quality of life scores. These findings highlight the urgent need to prioritize construction worker health through targeted interventions.

Effect of pharmaceutical pictograms on the textual comprehension of Prescription Medication Leaflets: A randomized controlled trial.

Clear patient instructions are essential in pharmaceutical care. However, literature reveals a consistent gap between the readability of medication messages and population skills. This study aimed to assess the comprehension of information in three Prescription Medication Leaflets, with and without supplementary US Pharmacopeia (USP) pictograms, among Spanish adolescents completing secondary education. We conducted a multicenter randomized controlled trial. From March to June 2022, 590 students were randomly assigned to read Prescription Medication Leaflets for ibuprofen, amoxicillin/clavulanic acid, and omeprazole, with or without USP pictograms. Comprehension was evaluated via questionnaire, alongside the European Health Literacy Survey short form, and sociodemographic data were collected. Mann-Whitney U and chi-square tests were used for analysis. Participant comprehension was significantly below the European standard, which requires at least 80% readability for Prescription Medication Leaflets, even with pictograms. Pictograms, however, significantly enhanced comprehension across all medication package inserts (p<0.001 for all comparisons), especially among students with higher health literacy. High health literacy was a statistically significant factor in comprehension only within the experimental group (p=0.005; p=0.039; p=0.004). The discouraging results highlight the imperative for innovation in medication labeling design, employing patient-centered approaches. USP pictograms have been shown to significantly enhance the reading comprehension of medication package inserts among the Spanish population.

Evaluation of health-related quality of life and performance in intestinal transplant and rehabilitation patients: a cross-sectional study.

We aimed to evaluate health-related quality of life (HRQoL) in intestinal failure (IF) patients after different modes of intestinal rehabilitation. HRQoL was assessed using the generic 36-item Short Form Survey (SF-36, ver. 2) and visual analogue scale (VAS) in 6 different areas: diet, sleep, gastrointestinal (GI) symptoms, diarrhea, musculoskeletal pain, and other symptoms. Twenty-two patients completed the questionnaires, of which 7 had received intestinal transplant (ITx), 9 were continuing home total parenteral nutrition (HPN), and 6 had tapered off total parenteral nutrition (TPN). SF-36 physical component summary scores were highest in the ITx group (median, 65.6; interquartile range [IQR], 31.6-80.3) compared to the HPN (median, 48.4; IQR, 44.7-66.3) or tapered group (median, 54.2; IQR, 45.2-61.6). Mental component summary scores were lowest in the ITx group (median, 48.8; IQR, 37.1-63.6), compared to the TPN (median, 60.2; IQR, 41.6-78.5) or tapered group (median, 51.0; IQR, 48.8-56.0). Differences were not significant in all items of the SF-36. VAS scores showed that patients in the ITx group showed the best results in diet (0.9), gastrointestinal (GI) symptoms (1.4), and musculoskeletal pain (2.4). There was a significant difference in sleep (P = 0.036), with the ITx (1.43) and HPN groups (1.33) showing better outcomes compared with the tapered group (4.67). Patients in the tapered group showed the least favorable results in all performance areas, except GI symptoms. SF-36 did not show a significant difference between the ITx, HPN, and tapered groups, but VAS showed a significant difference in sleep between groups. Further studies, including serial data, will allow a better understanding of the effects of different modes of intestinal rehabilitation.

Relation of Social Participation Restrictions with Worsening Quality of Life in Japanese Patients with Behçet's Disease: The 36-item Short Form Survey

Relation of Social Participation Restrictions with Worsening Quality of Life in Japanese Patients with Behçet's Disease: The 36-item Short Form Survey

A novel and alternative treatment method for moderate diabetic foot ulcer: tibial periosteal distraction

ObjectiveResearchers have proposed a novel surgical treatment for moderate diabetic foot ulcer: tibial periosteal distraction (TPD) which could improve affected limb microcirculation. We aimed to describe the method and therapeutic effects of this technique.MethodsWe provided a technical guide to perform TPD surgery for the treatment of moderate diabetic foot ulcer of who had been treated in our department. The demographic information had been collected at the time of their admission. The patients were followed up at 3, 6, and 12 months after the operation with the ulcer area, skin temperature of the medial malleolus, transcutaneous oxygen pressure of the medial malleolus, ankle brachial index, dorsalis pedis artery pulsation, 12 item short form survey quality of life scale score, and visual analogue scale.ResultsA total of 35 patients with type 2 diabetes were included in this study, including 19 males and 16 females, with an average age of 62.49 ± 10.34 years and a maximum age of 87 years. The ulcers of all patients were cured, and the average healing time of ulcers was 8.09 ± 2.28 weeks, with no associated complications. The microcirculation indexes of the affected foot were significantly improved (p < 0.05). Three cases showed new vessels regeneration in the affected limbs according to their computed tomography angiography (CTA) results.ConclusionTPD surgery technique is a simple procedure that significantly increases the efficacy and reduces the complications of moderate diabetic foot ulcer patients, which could accelerate the formation of collateral circulation.

Psychometric Validation of Nepali Version of Supportive Care Needs Survey Short-Form (SCNS-SF-34 -N) Among Nepali Cervical Cancer Patients

Background: Supportive Care Needs Survey Short Form (SCNS-SF-34) is commonly used tool for the assessment of supportive care needs among cancer patients. Cervical cancer is common cancer among women in Nepal and they are suffering from various types of problems compared with other cancer patients. It is necessary to assess the validity and reliability of the questionnaire after translating it in another language and going to be used. The study aimed to assess the validity and reliability of SCNS-SF-34 Nepali version among Nepali cervix cancer patients. Methods: 334 participants were recruited purposively from 5 cancers hospital. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA), structure validity, internal consistency convergent validity, and discriminant validity were calculated and confirmed. Results: Using EFA, a five-factor structure was developed considering higher loading factor for multiple loaded items which was similar with the dimensions of the original version of the SCNS-SF34 accounting for 65.48% of the total variance. CFA confirmed that the construct validity of SCNS-SF 34N was found at acceptable level. Cronbach's alpha coefficients was found from 0.789 to 0.929 for all five domains and 0.887 for the whole scale. Independent 't' test between known subgroups on age, marital status, stage of disease and treatment modalities confirmed discriminant validity. Conclusion: It was confirmed that the SCNS-SF 34 N is a valid and reliable instrument for the assessment of the supportive care needs among cervix cancer patients in Nepal.

Perception of health and illness and quality of life after total thyroidectomy for differentiated thyroid carcinoma: the PERSAM study.

Differentiated thyroid carcinoma is the most common endocrine neoplasm; several studies have shown that individuals perceive the disease as being more severe than it actually is, resulting in a reduced quality of life. The primary aim of this study is to assess the quality of life and perception of illness among patients admitted for radiometabolic therapy, post total thyroidectomy for differentiated thyroid carcinoma. The secondary aim is to identify which patient characteristics are associated with a lower quality of life in order to improve and personalize care. The study was conducted at the UOC of Radiotherapy Veneto Institute of Oncology IOV-IRCCS in Padua, Italy. Three questionnaires were administered: Psychological General Well-Being Index (PGWBI), the Illness Perception Questionnaire (IPQ-R) and the Short Form Survey (SF-12). A descriptive statistics analysis and multiple linear regression models were performed to explore the relationship between some of the variables. Significant associations emerged between the type of surgery and higher values on the PGWBI questionnaire (P = 0.022) and the score obtained in the 'emotional representations' dimension of the IPQ-R questionnaire (P = 0.028). Pathology staging was statistically significantly (P = 0.026) associated with the score obtained in the dimension 'identity'; age with the scores obtained in the dimensions 'emotional representations' (P = 0.035), 'personal control' (P = 0.004), 'consistency with pathology' (P < 0.001) and 'causes' (P = 0.004). There is evidence of moderate distress in psychological well-being and good perception of pathology. There is less understanding of the disease in individuals with stage 3 and 4 thyroid cancer, in those who have undergone total thyroidectomy without lymphadenectomy and who are aged over 60. Physical well-being: limitations in self-care and moderately physically demanding activities. Mental health: more information to patients decreases the degree of stress and promotes 'positive' emotions. Physical health status: a long-term activity program, characterized by aerobic exercises to be performed in groups or at home, is useful. This study allows to transpose the results into clinical practice, evaluating the possibility and methods of providing personalized care to patients.

Dorsal Root Ganglion Stimulation for Chronic Pelvic Pain Secondary to Endometriosis.

Chronic pelvic pain (CPP) is a multifaceted condition that poses significant challenges in clinical management owing to its complex and varied pathophysiology, including neuropathic, somatic, visceral, and musculoskeletal components. Endometriosis is frequently associated with CPP, necessitating a comprehensive, multimodal treatment strategy. This approach typically includes physical and behavioral therapy, pharmacologic interventions, surgical management of endometriosis, and various pain-modulating procedures. Neuromodulation, particularly spinal cord stimulation (SCS), has been used in refractory cases; however, its use is often met with limited success and a notable rate of explants. This case series presents nine patients with intractable CPP secondary to endometriosis, unresponsive to conventional treatments, who were treated with dorsal root ganglion stimulation (DRG-S). Between 2022 and 2023, ten patients with severe CPP secondary to endometriosis, unresponsive to various multimodal treatments-including previous interventional pain procedures, gynecologic surgery, and in some cases, SCS-were recruited for this prospective study. Of these, nine patients underwent permanent DRG-S, with bilateral L1 and S2 DRG-S leads placed (four leads per patient). Patients were assessed for pain intensity using the visual analog scale (VAS), narcotic consumption, and quality of life (QoL) using the 12-item short-form (SF-12) survey, with a 12-month follow-up period. Nonparametric statistical analyses were conducted using SPSS. One patient was excluded from the study owing to a lack of pain relief during the DRG-S trial. The remaining nine patients underwent permanent bilateral L1 and S2 DRG-S placement. Significant improvement in pain scores was observed and sustained throughout the follow-up period (VAS 9± 1.5-2± 2.0; p= 0.003), along with a marked reduction in opioid consumption, with four patients becoming completely free of narcotics (p= 0.046). SF-12 physical scores improved by 60.2± 7.8 (p= 0.006), and SF-12 mental scores improved by 45.9± 2.76 (p= 0.01). Bilateral L1 and S2 DRG-S yielded robust and sustained outcomes, including significant improvements in pain scores, reduced narcotic consumption, and enhanced QoL over a 12-month follow-up period.

Effect of Thai Yoga Exercise for Reducing Pain and Improve Functional Disability in Patients with Text Neck Syndrome: A Randomized Controlled Trial

Text neck syndrome (TNS) is prevalent among mobile users, and exercise is a simple, non-invasive approach, for treating chronic neck pain. Research on Thai yoga (TY) exercise to relieve or reduce neck and shoulder pain in people with TNS is still limited. This study aimed to investigate the effects of TY exercise on health, physical function and quality of life in patients with TNS. A randomized clinical trial was conducted from April to July 2023 (TCTR20230920002, 10/2023). Seventy-eight volunteers with TNS participated in the study, performing TY exercises, while continuing their routine daily life (CON) for 6 weeks, with week 8 as a follow-up appointment. Clinical evaluation was conducted using a numerical pain-rating scale, functional disability scored by the neck disability index questionnaire (NDI), range of motion (ROM) and cervical vertebral angle, rounded shoulder angle by goniometry, and health-related quality of life (QoL) assessed by the 36-Item Short Form Survey. The results of the numerical pain-rating scale for TY group in the follow-up (6.71±0.52 weeks) were significantly different (p-value &lt; 0.001) from the baseline (4.18±0.95) while the CON group showed no change. The NDI also decreased from the baseline (5.03±1.38) in the TY group, while the CON group remained at 12.03±1.98. The data of craniovertebral angle of TY group show an increase from baseline (62.44±2.32) while CON group was 39.37±4.73. The results showed that the rounded shoulder angle of TY group decreased to the normal range. The TY group shows an increased degree from baseline. The results for the TY group demonstrated a significant increase in QoL. These findings suggest that TY exercise is effective for relieving TNS when compared with the CON group. These positive outcomes provide strong support for the use of TY as an effective intervention for treating TNS symptoms.