A zoonotic orthopoxvirus called human monkey pox has symptoms that resemble smallpox. It is challenging to clinically distinguish the condition from varicella and smallpox. The identification and surveillance of diseases rely heavily on laboratory diagnostics, and novel tests are required for a quicker and more accurate diagnosis. The bulk of human infections occur in Central Africa, where surveillance in underdeveloped rural regions can be challenging but is possible with the help of technologies that are evidence-based and materials that teach public health professionals about key concepts. Now that smallpox immunization is not a common practice, epidemiological studies are required. For the treatment and averting monkey pox, new medications and vaccines provide hope. They need more study before they can be used in an endemic environment, though. To better understand and prevent human infections, there is a need for additional research into the biology, ecology, and epidemiology of the virus in endemic areas. The research shows smallpox symptoms and signs are similar to those of human monkey pox. The virus that causes monkey pox can alter the genetic makeup of the virus, ecological changes, and host behaviour, raising concerns that it may evolve into a more dangerous illness in humans. Humans can contract the virus by being bitten by an infected animal, coming into contact with its blood, body fluids, or fur, or by petting infected animals. Meat that has been inadequately processed from a sick animal may be contagious. Humans can catch the virus by touching an infected person's skin blisters or scabs, coming into contact with cough droplets, or by using bedding, clothing, or towels that have been worn by someone who has a rash. Moreover, experts believe sexual contact can also spread the infection.