The selection of the surgical treatment method for glaucoma, as a means of controlling intraocular pressure and stabilizing the glaucomatous process, remains a major challenge in ophthalmology. Laser cyclodestructive interventions offer the possibility of regulating the power and duration of exposure, thus expanding the range of tasks the method can address. This study aimed to compare the degree of postoperative inflammatory response in the anterior chamber of the eye between cyclodestructive interventions with and without the realization of the vaporization biological effect. In the first experimental group of rabbit eyes, the intervention was performed before visual coagulation of the processes, with power ranging from 0.3 to 0.5 W. In the second group, the intervention was performed before the visual realization of the biological vaporization effect, with power ranging from 0.9 to 1.2 W. Clinical observations were retrospectively conducted within the studied group of patients who underwent combined (phacoemulsification + endoscopic laser cyclophotocoagulation) intervention. Throughout the comparison of experimental groups, no statistically significant differences were found. However, a significantly higher inflammatory reaction was observed almost three times more frequently (p = 0.008) in patients where the vaporization biological effect was not fixed. Therefore, despite the results of the experimental study suggesting that excessive damage to the ciliary processes due to the realization of the vaporization effect does not lead to a significant increase in the intensity of the inflammatory response, the clinical observations suggest avoiding such damages whenever possible. Keywords: postoperative iridocyclitis, endoscopic laser cyclodestruction, optical coherence tomography.