To compare surgical site infection (SSI) rates prior to and after implementation of a SSI bundle and checklist for scheduled hysterectomies at Prentice Women’s Hospital. Components are based on prior SSI bundles described in the literature and include patient use of chlorhexidine gluconate (CHG) at home prior to the surgery, surgical site hair clipping in the preoperative area, CHG vaginal prep, use of a plastic retractor when appropriate, and the changing of personal protective equipment (PPE) prior to skin closure. Eligibility criteria included any open, laparoscopic and robotic hysterectomies performed at Prentice Women’s Hospital from February 1 to July 31, 2017. Patients were 18 years of age or older. Exclusion criteria included non-scheduled, emergency hysterectomies or hysterectomy done at the time of cesarean section. The Healthcare Epidemiology and Infection Prevention department data was used to measure the surgical site infection rates both before and after implementation of the SSI bundle. Compliance with the individual components of the checklist was gathered through nursing-completed forms (“Checklists”) for all patients undergoing scheduled hysterectomies. These forms were completed both in the pre-operative holding area and in the operating room. The study was submitted to the Institutional Review Board and deemed to not require review. Compared to surgical site infections before implementation of the bundle and checklist, infections dropped from 2/209 to 0/281, representing a significant decrease (P = 0.01). Checklists were completed in 65% of cases overall, with an increase from 60% at the beginning of the intervention to 70% currently. Of the cases with a completed checklist, 29% of patients used CHG at home prior to the surgery, and of those who did not, 96% were given a CHG wipe in the preoperative area prior to the surgery. Compliance with surgical site hair clipping and CHG vaginal prep were 60% and 97%, respectively. The compliance rates for hair clipping increased from 41% to 75% through the implementation period. Prior to skin closure, gloves were changed in 63% of cases while gowns were changed in 23% of cases. Of non-oncologic abdominal hysterectomies during this time, 55% recorded use of metal retractors while 9% recorded use of plastic retractors. After implementation of the SSI bundle for scheduled hysterectomies, surgical site infection rates significantly decreased from historical values. Over the course of a 6-month data gathering period, we found that patients tend to not complete the requested CHG wipe at home. However, for those patients who have not performed the prerequisite wipe, nursing staff nearly always performed the wipe prior to surgery. Of the interventions implemented, the highest compliance items were nursing-led activities including preoperative CHG wipe and hair clipping, and intraoperative vaginal CHG prep. On the other hand, surgeon-directed items including PPE change and retractor use had low compliance throughout the intervention period. Overall, we have shown that implementation of a few simple, cost-efficient techniques can significantly affect an institution’s SSI rates.