Introduction: Enhanced recovery after surgery protocols (ERAS) have gained wide acceptance in several sub-specialties, however, there is to date limited data on for their use in pancreatic surgery. The aim of this study was to present our experience implementing ERAS in patients undergoing pancreatoduodenectomy (PD). Materials & Methods: All patients undergoing PD between January 2014 and December 2017 were identified from institutional American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) data. The cohort was divided by year of procedure into Pre-ERAS (2014/2015) and ERAS (2016/2017) groups. Data collected includes patient baseline demographics, perioperative data, and outcome measures including 30-day readmissions. Results: A total of 294 patients underwent PD during the study period. There were 156 (53.1%) patients in the Pre-ERAS group and 138 (46.9%) in the ERAS cohort. The length of stay [LOS], calculated from the procedure day to discharge, was 7 (IQR=6-10) and 6 (IQR=5-9) for Pre-ERAS and ERAS groups (p=0.014), respectively. The re-intubation rate was lower (7.1 vs. 1.2%; 0.009) as were the rates for overall (35.9% vs. 14.7%; p<0.001) and clinically-relevant post-operative pancreatic fistula (19.9% vs. 3.6%; p<0.001). The organ-space surgical site infection (14.1% vs.9.8%; p=0.237), delayed gastric emptying (19.9% vs. 13.5%; p=0.126), and 30-day readmission (17.3% vs. 14.1%; p=0.528) rates were all lower in the ERAS group. The 30-day mortality was also lower in the ERAS group (1.9% vs. 0%; p=0.116). Conclusions: This study demonstrated that the institution of an ERAS protocol for patients undergoing PD resulted in a reduced length of stay and was safe, with no increase in reoperation rate, 30-day readmission rate or mortality. Indeed, the Introduction of ERAS led to standardization of care which is likely responsible for improvements in post-operative complications in particular POPF. Future studies should also focus on patient reported outcomes in addition to the above metrics.