For the past few decades, coronary artery bypass grafting (CABG) using cardiopulmonary bypass and cardioplegic arrest (ONCAB) has been considered the standard for surgical coronary revascularization. Since the mid-1990s, there has been increased interest in avoiding the use of extracorporeal circulation and the bypass circuit during construction of the distal anastomoses. This interest in off-pump coronary artery bypass grafting (OPCAB) has, in large part, been because of the detrimental effects of cardiopulmonary bypass; specifically the inflammation response, adverse neurological outcomes, and the multi-system organ injury that may occur. Importantly, OPCAB has been associated with reduced myocardial enzyme release, lower transfusion requirement, reduced pulmonary and renal complications, shorter length of stay, and lower cost.1,2 Article see p 2827 Currently, OPCAB accounts for approximately 20% to 25% of coronary artery bypass cases in the United States and has not changed significantly for ≈5 years. It is plausible that the lack of compelling evidence for a mortality benefit of OPCAB in randomized, controlled trials has been an impediment to broader adoption of this strategy in routine practice.3 Furthermore, many surgeons consider OPCAB more technically challenging, especially when grafting the lateral wall. For certain subgroups of patients, such as patients undergoing single- and double-vessel coronary bypass or high-risk candidates, it would appear intuitive that avoiding the systemic effects of cardiopulmonary bypass, as well as aortic manipulation, would reduce the incidence of specific complications.4 However, until definitive studies prove an advantage of one technique over the other, the preferred approach will ultimately be dictated by the surgeon's comfort level and expertise. Patient outcomes with the use of OPCAB techniques have been studied in numerous prospective randomized trials1–2,5–7 and in retrospective reviews of individual institutions and large society- and Veterans Affairs–based databases reporting that …
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