A new space era begins with the Artemis Accords. These will allow the return of humans to the Moon. The starting point of this historic period was marked by the signing of this international agreement on October 13, 2020. Eight States are at the origin of these accords: the United States of America, Australia, Canada, Italy, Japan, Luxembourg, the United Arab Emirates, and the United Kingdom. Since then, thirteen other governments – including France – have joined this international space program led by NASA. Artemis will require the implementation of a new communication architecture called “LunaNet”, encompassing the search and rescue service known as “LunaSAR”. Therefore, like on Earth, on the Moon, search and rescue of people in distress will require the interoperability of international communications. From a legal point of view, the Artemis Accords are based on existing space law, particularly the 1967 Outer Space Treaty. According to this, Lunar missions shall be conducted for peaceful purposes. Transparency in the implementation of international partnerships is another key principle of this space program. From this, at the operational level, interoperability of the systems based on existing or future standards naturally follows. Beyond the technical or commercial aspects, what takes precedence over all other considerations is the safety of the astronauts working for the completion of the Artemis program. Thus, generally, the possible assistance brought to the astronauts in distress is foreseen in the United Nations treaties and principles on outer space. Regarding the implementation of the Artemis program, personnel will operate on board a spacecraft, a space station, or from the surface of the Moon. This is why NASA plans to implement the Astronaut's Lunar Lifeline, known as Lunar Search and Rescue or LunaSAR. Integrated with the LunaNet system, this system will assist workers in distress. In this study, therefore, we will focus on standards for communications interoperability, in the context of search and rescue of persons in distress. To do so, we will examine the Artemis program through the lens of satellite-assisted Earth search and rescue principles and techniques. In particular, we will focus on the COSPAS-SARSAT alerting service and the International Aeronautical and Maritime Search and Rescue (IAMSAR) Manual. In this context, issues such as, for example, the implementation of the Treaty on Principles Governing the Activities of States in the Exploration and Use of Outer Space, including the Moon and Other Celestial Bodies of 1967, the Agreement on the Rescue of Astronauts, the Return of Astronauts and the Return of Objects Launched into Outer Space of 1968 and the Agreement Governing the Activities of States on the Moon and Other Celestial Bodies of 1979 as well as the protection of SAR frequencies and potential harmful interference will be addressed.