The water resource management of transboundary mountainous river basins under climate change is expected to be challenging. In order to contribute to the better understanding of climate change effects on the water resources of the mountainous and transboundary Prespa Lakes basin, a hydrological model of the Agios Germanos River, one of the main rivers discharging to Great Prespa Lake, was developed, and two water management plans under two different climate scenarios were examined. Based on the results, the impact of climate change on surface water resources was evident in all climate change scenarios examined, even under the most favorable water abstraction practices. Nevertheless, sensible water management can moderate the impact of climate change by up to 10% in an optimistic scenario in both the near- and long-term, and by up to 6% and 1% for the near- and long-term, respectively, in a pessimistic scenario. Integrated water management practices that moderate the impact of climate change on the water ecosystem services should be prioritized. Nature-based approaches could provide solutions regarding climate change adaptation and mitigation. Transboundary cooperation, data exchange mechanisms, common policy frameworks, and monitoring, reporting, and evaluation systems, could reduce human and ecosystems’ vulnerabilities and improve the water security of the area.
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