The formation and evolution of micron-sized droplets of a Newtonian liquid generated on demand in an industrial inkjet printhead are studied experimentally and simulated numerically. The shapes and positions of droplets during droplet formation are observed using a high-speed camera and compared with their numerically obtained analogs. Both the experiments and the simulations use practical length scales for inkjet printing. The results show how fluid properties, specifically viscosity and surface tension, affect the drop formation, ligament length, and breakoff time. We identify the parameter space of fluid properties for producing single drops at a prescribed speed and show this is not simply a restriction on the Ohnesorge number, but that there is an additional restriction on the Reynolds number that is distinct from the Reynolds number limit associated with the prevention of splashing. This phase diagram provides more precise guidance on the space of fluid parameters for jetting single droplets in drop-on-demand inkjet printers.