Roughness is one of the most significant parameters in the evaluation of pavement performance. Surface distresses are among the main factors leading to roughness. The collection and evaluation of roughness data require the application of modern equipment such as road surface profilers. In the absence of such equipment, roughness prediction models that are based on surface distresses might provide a desirable assessment of pavement conditions. This research employs the laser crack measurement system (LCMS) to detect and measure surface distresses and roughness along 268 km of primary roads in Iran. Compared with manual survey, LCMS provides maximum detection and measurement accuracy. Based on the LCMS output, distresses with a higher correlation with the International Roughness Index (IRI) were selected as predictors in linear regression models and artificial neural networks (ANN). The models were developed for 10 m and 100 m length sections of the roads under different climate and traffic conditions. The results indicate that the performance of ANN for the 100 m sections with coefficient of determination ( R2) of 0.82 is superior to other models. The best case was that of using ANN in 100 m sections for regions with moderate climate and medium traffic levels, with a 0.94 correlation. Satisfactory results in field validation of the models demonstrated that agencies can use other methods of data collection (e.g., manual, right of way [ROW]) to assess the surface distresses and roughness condition of their roads from the developed models with minimum spending and without expensive equipment. Such estimates can be employed to make informed decisions in pavement maintenance programs at the network level.