Fiber Surface Plasmon Resonance Sensor Research Articles

High sensitivity fiber optic SPR sensor for selenium ion concentration detection

Balance of selenium content is of great significance to human health, and there is a need for rapid and sensitive detection of selenium ion concentrations in the human body and food. This article proposes a highly sensitive fiber surface plasmon resonance (SPR) sensor for selenium ion concentration detection. By fabricating a fiber U-shaped ring composite structure and modifying Cu3VSe4 material, the sensitivity of the fiber SPR sensor is improved to 6826.82 nm/RIU. Using 2,4-diamino-6phenyl-1,3,5-triazine to modify the surface of the sensor to achieve specific detection of selenium ion concentration. The experiment results indicate that the detection sensitivity of the sensor is 1.858 nm/(lg(pg/ml)) with range of 100 pg/ml to 1 μg/ml, and the LOD is 124.06 pg/ml. The highly sensitive SPR sensor proposed in this article, without labeling, can achieve high sensitivity and rapid detection of selenium ions, providing a new approach for trace element content detection.

[formula omitted] modified U-shaped fiber surface plasmon resonance sensor with high sensitivity

Design of optical fiber structure and sensitive material coating are two effective performance improvement approaches for fiber optic surface plasmon resonance (SPR) sensors. Here, a tungsten diselenide (WSe2) modified U-shaped fiber optic SPR sensor is proposed. It is found that the sensing performances of the proposed U-shaped probe can be controlled with the thickness of gold film, WSe2 layers, and bending radius of the U-shaped fiber. A sensitivity of 27520 nm/RIU (RIU: refractive index unit) is obtained with the optimized U-shaped probe, which is about 11.56-fold and 12.29-fold improvements over the traditional in-line transmission fiber optic SPR sensors without WSe2 coating and with monolayer WSe2, respectively. These results demonstrate a promising approach for sensitivity improvement of fiber optic SPR sensors, and the proposed WSe2 modified U-shaped fiber optic SPR sensor may have prospective potential applications in biological sensing, chemical sensing, and environmental monitoring.

Gratings for enhanced sensitivity: advancing D-shaped optical fiber surface plasmon resonance sensors with Ag-Fe2O3 structures

This research delves into enhancing biosensing sensitivity by optimizing D-shaped optical fiber surface plasmon resonance (SPR) sensors employing Ag-Fe2O3 structures. By investigating the influence of different grating structures—rectangular, triangular, and elliptical—on sensor performance, a comprehensive analysis was conducted to ascertain the impact of these structural variations on sensitivity and detection precision. The study revealed that while the rectangular structure exhibited a sensitivity of 6.4 µm/RIU, the triangular structure outperformed with an impressive sensitivity of 7.2 µm/RIU. Moreover, the detection accuracy, quantified by the detection angle (DA), reached 15.7(µm)−1 for the triangular grating, surpassing the rectangular grating’s detection angle of 14.8(µm)−1. These results underscore the crucial role of structural design in enhancing sensor performance, with the triangular grating demonstrating superior sensitivity and detection precision in the context of plasmonic resonance. The extended detection range of refractive indices around 1.39 further expands the sensor’s applicability in diverse chemical and biomedical analyses. Notably, the sensor’s capability to detect various chemical solutions and diseases—including plasma, tuberculosis, white blood cells, and breast cancer cells—underscores its versatility and efficacy in dual-parameter detection. Through meticulous simulations and analysis, this study provides valuable insights into optimizing sensor sensitivity, detection accuracy, and application versatility, paving the way for advanced developments in biosensing technology with far-reaching implications for chemical and biomedical research.

Cascaded dual-parameter SPR fiber sensor for RI and pH simultaneous detection based on Ag film and an Ag/self-assembled nanofilm structure

To achieve more accurate analysis and detection of changes in liquid parameters, we propose a dual-parameter surface plasmon resonance (SPR) sensor that can measure refractive index (RI) and pH simultaneously. In this paper, we compare and analyze the transmission spectrum when the SPR effect is excited by the cladding mode of a photonic crystal fiber (PCF) and the core mode of the no-core fiber. The results show that the SPR effect excited using the cladding mode is stronger and the sensor has better loss peaks, which is more conducive to realizing the detection of the external environment. Therefore, the sensor uses PCF as the substrate and utilizes a cascade composite film structure, and the area where a silver film is deposited on the surface of the PCF is selected as the RI sensing area. Another part of the PCF, after the silver film is deposited, uses a high-sensitivity polyacrylic acid/chitosan self-assembled nanofilm as the pH-sensitive film. Experimental results show that the maximum sensitivity is 4122.44 nm/RIU and -57.82 nm/pH when the RI range is between 1.333 and 1.385 and the pH range is between 3.11 and 8.63, respectively. In addition, we experimentally verified that the sensor had good stability and repeatability. The design of the sensor provides new possibilities for real-time monitoring and precise control, helping to advance scientific research and the development of industry.

Surface electric field enhanced biosensor based on symmetrical U-tapered HCF structure for gastric carcinoma biomarker trace detection

In this article, a novel U-tapered hollow-core fiber (HCF) surface plasmon resonance (SPR) biosensor coated with PtS2 for early-stage gastric carcinoma (GC) diagnosis was demonstrated. The article proposed the first investigation to detect Interleukin-10 (IL10) and Interleukin-1β (IL1β) which were associated with the risk of developing gastric carcinoma, using optical fiber SPR technology. Herein, the sensitivity of sensor was effectively improved through a combination of tapered and U-shaped structures. Additionally, to further enhance the detection capability, two-dimensional material PtS2 was utilized to increase the surface electric field intensity of the sensor. Simultaneously, optimization of structural parameters such as taper ratio, bending diameters, and Au film thickness was conducted. Ultimately, the designed sensor achieved a remarkable sensitivity of 13210 nm/RIU within the refractive index (RI) range of 1.33–1.37. The sensor demonstrated exceptional performance, achieving sensitivities of 3.64 nm/(ng/ml) and 7.46 nm/(ng/ml) for the detection of IL10 and IL1β biomarkers, respectively, along with limit of detection (LOD) of 2.74 pg/ml and 1.33 pg/ml, and successfully detecting the presence of these biomarkers in the serum of gastric cancer patients. Overall, the proposed sensor exhibits significant potential in early gastric cancer detection and advances the application of optical fiber SPR sensors in trace biodetection.

Simulation analysis of a photonic crystal fiber refractive index sensor based on a double-layer film structure and surface plasmon resonance technology

A photonic crystal fiber surface plasmon resonance sensor based on a double-layer membrane structure is designed and analyzed. In the simple sensing structure with only one air hole size, TiO2 and Au layers with specific thicknesses are sequentially coated on the optical fiber to form a double-layer structure. The sensing characteristics of the double-layer membrane structure are studied by the finite element method. Compared to the single-layer membrane structure, the double-layer membrane sensor has significant sensing properties such as a better wavelength sensitivity and a smaller full width at half maximum in the loss spectrum. In the refractive index range between 1.37 and 1.43, the maximum wavelength sensitivity and average wavelength sensitivity of the sensor are 19,900 nm/RIU and 7417 nm/RIU, respectively, and the resolution can be up to 5.03×10−6RIU. The proposed photonic crystal fiber optic sensor achieves high performance with a simpler sensing structure than previous photonic crystal fiber optic sensors, and eliminates the step of polishing, which will greatly reduce the difficulty of actual fabrication and the error due to uneven polishing. The results show that the photonic crystal fiber optic sensor with a double-layer membrane structure has excellent performance. Due to its high sensitivity and resolution, it has great potential for applications in environmental monitoring, biosensing and chemical sensing.

Highly sensitive near-field leakage-enhanced optical fiber SPR sensor based on gold nanoarrays modulation

A novel near-field leakage-enhanced optical fiber surface plasmon resonance (NLF-SPR) sensor based on the synergistic sensitization of cuboid gold nanoarrays and WSe2 film is proposed for the first time to our knowledge. The sensor is composed of a side-polished multimode fiber, a continuous gold film, a continuous tungsten selenide (WSe2) film, and well-arranged cuboid gold nanoarrays. The sensor leverages the high carrier mobility characteristic of the WSe2 film, the near-field leakage enhancement arising from the nanoarrays structure, and the localized electric field enhancement property introduced by nanotips to enhance the refractive index sensitivity. In order to optimize the spectral characteristic, the modulation of electric field distribution and spectral characteristic by the structural parameters of gold nanoarrays is investigated through three-dimensional (3D) finite element simulation. Results show that in the refractive index range of 1.3332–1.3432 refractive index unit (RIU), the average sensitivity of the NLF-SPR sensor can reach up to 10108 nm/RIU, and the highest sensitivity can reach up to 14692.46 nm/RIU. The average sensitivity and the highest sensitivity are 1.87 times and 2.56 times higher, respectively, than those of the side-polished fiber SPR sensor with a monolayer gold film. Furthermore, the experimental results demonstrate that the near-field leakage enhancement introduced by gold nanoarrays improves the performance of the fiber SPR sensor, resulting in a 49.3 % increment in sensitivity. The experimental results are in agreement with the trend of the simulation results. Even better performance improvements have been achieved compared to existing methods and a more flexible approach to performance tuning is provided. With the maturity and development of various nanoarray processing techniques such as focused ion beam, electron beam lithography, and nanoimprint lithography, the proposed NLF-SPR sensor has the potential to be fabricated on a large scale and is expected to be widely employed in biomedical, clinical applications, and other fields.

Optical fiber sensor based on magneto-optical surface plasmon resonance with ultra-high figure of merit

Compared to surface plasmon resonance (SPR), the sensors based on the magneto-optical SPR (MOSPR) technique have much higher figure-of-merit (FOM). However, there are no reports about applying MOSPR in the optical fiber structure now. In this work, a novel D-shaped optical fiber sensor based on the MOSPR technique is proposed. The D-shaped optical fiber is coated with a thin silver film and a magneto-optical (MO) material film of Cerium-doped Yttrium-Iron garnet (CeYIG). By applying a magnetic field on the sensing region, the magneto-optical Kerr effect (MOKE) of the CeYIG layer and the related MOSPR phenomenon could be excited when appropriate light is transmitted in the proposed optical fiber sensor. The influence of the structural parameters including the residual cladding thickness, silver and MO material film thicknesses are analyzed theoretically by the finite element method (FEM). With the optimal parameters, the sensor achieves the sensitivity of 5304 nm RIU−1. Since the peak width of MOSPR spectra is much narrower than that of the SPR spectra, the FOM of the sensor is largely enhanced to 3864 RIU−1 on average and 13260 RIU−1 in maximum, which surpasses the optical fiber SPR sensors vastly. The miniaturized and simple design of the D-shaped optical fiber MOSPR sensor, coupled with the ultra-high FOM, offers itself great potential in biochemical sensing applications.

Triple-Channel Optical Fiber Surface Plasmon Resonance Sensor for Simultaneous Detection of Relative Humidity, Magnetic Field, and Temperature

Triple-Channel Optical Fiber Surface Plasmon Resonance Sensor for Simultaneous Detection of Relative Humidity, Magnetic Field, and Temperature

Surface plasmon resonance sensor of hollow microstructure fiber based on ZIF-8 thin film

An annular hollow microstructured fiber surface plasmon resonance (SPR) sensor based on ZIF-8 film is proposed for the measurement of CO2 concentration in air. Internal detection is adopted to enhance the spectral response to CO2 gas, and nano-gold pillars are embedded on both sides of the channel. The geometric parameters of the sensor are optimized to achieve an average sensitivity of 1.01 nm/% over the range of CO2 concentration from 0% to 100%. The results indicate that the sensor is a promising SPR gas sensor with great potential in CO2 detection applications.

S-shaped tellurite optical fiber surface plasmon resonance sensor for temperature and refractive index measurement

In this paper, an all-fiber S-shaped structure optical fiber surface plasmon resonance (SPR) sensor is proposed for temperature and refractive index measurement. The sensor is made of a single-mode tellurite optical fiber (TOF), and the middle part of the single-mode TOF is heated by a ceramic heating rod to form an S-shaped sensing region, and a 50 nm gold film is deposited in the S-shape sensing area to excite SPR. Based on the excellent properties of tellurite optical fiber, the prepared optical fiber sensor can be used for high sensitivity temperature and refractive index detection. The highest refractive index sensitivity is up to 1068.59 nm/RIU in the range of 1.333–1.380, and the temperature sensitivity is up to −0.713 nm/°C in the range of 30–150 °C. The proposed sensor is simple to fabricate, low-cost, and compact, and can be widely used in biochemical analysis, complex environmental temperature monitoring and other fields.

Numerical analysis of a single channel exposed core elliptical shaped PCF based highly sensitive SPR sensor for wide RI sensing.

This study presents a numerical study of a highly sensitive photonic crystal fiber (PCF) surface plasmon resonance (SPR) sensor capable of detecting five types of cancer and bacterial contamination in water. By precisely arranging only two air holes in a single channel of an elliptical-shaped PCF, the sensor maximizes interaction between core-guided modes and surface plasmon polaritons (SPP) along the fiber. Evaluation using COMSOL Multiphysics simulation software, based on finite element method (FEM), demonstrates outstanding sensor performance across a wide refractive index (RI) range (1.33 to 1.43). With a maximum wavelength sensitivity (WS) of 188,000 nm/RIU and amplitude sensitivity (AS) of -22,377.99 RIU-1, the sensor achieveStructural Design and Methodologys a sensor resolution (SR) of 5.3191 × 10-7 RIU and figure of merit (FOM) of 854.55 RIU-1. Notably, it exhibits AS and WS values tailored for specific cancer cell types and water contamination. These results endorse the sensor's potential in diverse biological and molecular analyte RI detection applications within the visible to near-infrared (VNIR) range (0.55 to 4 µm), offering high sensitivity, affordability, wide sensing range, good linearity, low propagation loss, and simplicity in construction.

A PCF-SPR sensor for dual-polarization and wide refractive index detection range

In this paper, we design a novel H-shaped photonic crystal fiber (PCF) surface plasmon resonance (SPR) sensor, which is composed of a dual-sided U-shaped groove and an Ag–MoS2 coating. The proposed sensor exhibits an asymmetrical structure with birefringence, which provides a possible way to detect the refractive index (RI) of analytes with dual-polarization. Based on the finite element method (FEM) simulations, the influences of the structural parameters on the sensing performances are discussed. For y-polarization, the proposed sensor detects the changes of RI from 1.37 to 1.41 with a maximum wavelength sensitivity of 11,700 nm/RIU, while for x-polarization, RI changes from 1.29 to 1.35 with a maximum sensitivity of 7800 nm/RIU. Thus, a PCF-SPR sensor with dual-polarization and wide RI detection range is achieved, which holds significant promise for applications in biology, medicine, and food safety.

Temperature self-compensated fiber-optic Pb(II) sensor with improved selectivity by Resorcylaldehyde post-modified organic metal framework

Post-modification of metal-organic framework (MOF) materials is an effective means to enhance their efficient and selective adsorption for heavy metal ions. In this article, we presented a reflection-type optical fiber surface plasmon resonance (SPR) sensor based on dual core fiber (DCF) coated with UiO-66-RSA (UiO-66-NH2 post-modified with resorcinol aldehyde) film for the specific detection of Pb(II) in aqueous media. The composite material UiO-66-RSA exhibits stronger affinity and specificity for Pb(II) than UiO-66-NH2. The adsorption of Pb(II) can change the equivalent refractive index (RI) of UiO-66-RSA film, causing a regular shift in SPR spectra. Experiments have shown that the limit of detection (LOD) of the SPR Pb(II) sensor can reach 0.1 nM. Meanwhile, research has found that the SPR sensor is accompanied by temperature crosstalk of 0.356 nm/°C. Therefore, we constructed a Michelson temperature interferometer using polymer micro tips on the end face of the fiber core to achieve temperature compensation. Based on the above two sensing channels, dual parameter demodulation of Pb(II) concentration and temperature can be achieved with an error rate of less than 0.5 %. This article has potential research value in exploring the application of post modification techniques of MOF in fiber optic lead ion detection.

Reflective optical fiber SPR sensor with DNA modification for high-sensitive Hg2+ concentration measurement

A reflective optical fiber surface plasmon resonance (SPR) sensor was proposed to measure the concentration of mercury ions (Hg2+). The specific single-stranded DNA was modified on the optical fiber sensing surface coated with Au film by the combination of covalent bond and charge adsorption. The Hg2+ can mismatch with T-T (thymine-thymine) base pairs in single-stranded DNA to form T-Hg2+-T structure, which led to the change of refractive index in sensing area and the wavelength shift of SPR spectrum. The measurement results showed that when the concentration of Hg2+ increased from 0 μM to 13 μM, the resonance spectrum shifted by 14.26 nm. In the linear range between 1–8 μM, the measurement sensitivity of the sensor could reach 1.51 nm/μM. The limit of detection (LOD) was found to be 0.28 μM. Besides, the sensor showed good stability, selectivity and reusability.

Highly-Sensitive Polymer Optical Fiber SPR Sensor for Fast Immunoassay

A new type of human immunoglobulin G (IgG) sensors based on the surface plasmon resonance (SPR) in the low refractive index (RI) plastic optical fiber (POF) and an antibody immobilization method is presented. A 50-nm-thick gold film was formed on the polished D-shaped fiber surface by magnetron sputtering. The RI response of the POF sensor is 30 049.61 nm/RIU, which is 26.5 times higher than that of single mode fiber (SMF) SPR sensors. The proposed SPR biosensor can be developed by simple and rapid modification of the gold film with 11-mercapto undecanoic acid (MUA). Upon immobilization of the goat anti-human IgG antibody, the resonance wavelength shifts by 11.2 nm. The sensor can be used to specifically detect and quantify the human IgG at concentrations down to 245.4 ng/mL with the sensitivity of 1.327 7 nm per µg/mL, which offers an enhancement of 12.5-fold compared to that of the conventional SMF based SPR sensors. The proposed device may find the potential applications in the case of use at the point of care.

Wave type fiber SPR sensor for rapid and highly sensitive detection of hyperoside.

The fiber surface plasmon resonance (SPR) sensor used for the detection of active ingredients in traditional Chinese medicine has the problems of low sensitivity and difficult specific recognition. This paper proposed a wave type fiber SPR sensor, which reduced the mode of transmitted light through a periodic wave structure and caused concentrated and total reflection of the transmitted beam at the interface between the bent peak cladding and the air. A 50 nm gold film was coated on the surface of the cladding in the wave structure area to form the SPR sensing area. By controlling the width and height of the wave structure to control the total reflection angle of the transmitted light, i.e., the SPR incidence angle, the sensitivity of the fiber SPR sensor was effectively improved to 4972 nm/RIU. Furthermore, HSP90AA protein was modified on the gold film of the sensor to achieve specific detection of hyperoside. The longest single detection time was only 3 minutes, and the detection sensitivity was 0.53 nm/(µg/ml), with a detection limit as low as 0.68µg/ml, which is comparable to liquid chromatography. The proposed wave type fiber SPR sensor is fast in production and has high structural mechanical strength, providing a new approach for the rapid, highly sensitive, and specific detection of active ingredients in traditional Chinese medicine.

Sodium-based no-core fiber surface plasmon resonance sensor with high sensitivity and narrow FWHM

Since fiber-optic sensors using noble metal-excited surface plasmon resonance (SPR) effects have encountered bottlenecks in improving performance, we propose a fiber-optic sensor using sodium in combination with a no-core fiber (NCF) to measure both refractive index (RI) and temperature. We deposited sodium thin films on the surface of NCF optical fibers and protected them with polymethyl methacrylate (PMMA) or polydimethylsiloxane (PDMS) for RI sensing or temperature sensing. We performed computational simulations and performance analyses of the sensors using the finite element method, and the results show that the sodium-based SPR sensors have higher sensitivity, wider detection range, and narrower full width at half-maximum (FWHM) than the noble metal SPR sensors. SPR sensors with different sodium film thicknesses have different sensing characteristics, so we can get optical fiber sensors with more flexible transmission characteristics, which helps us arrange sensors more conveniently in practical applications. The simulation and numerical results show that when the sensor is used to measure RI, the average sensitivity of the sensor can reach 7977 nm RIU−1, the maximum sensitivity can reach 23100 nm RIU−1, the narrowest FWHM is 14.23 nm, and the maximum figure of merit (FOM) is 719.42 RIU−1 under different thicknesses of sodium film. The corresponding RI ranges from 1.32 to 1.41. When the temperature measurement range is 0 °C ∼ 100 °C, the average sensitivity can reach 7.86 nm °C−1, the maximum temperature sensitivity can reach 21.1 nm °C−1, and the narrowest FWHM is 17.84 nm. In summary, the proposed sodium-based SPR sensor has flexible and high-performance sensing characteristics, and our research work provides more powerful theoretical support for the application of sodium-based plasma devices.

High sensitive optical fiber SPR sensor for label-free detection of Staphylococcus aureus

Optical fiber bacterial sensors have attracted attention in many fields due to their unique advantages. However, it is still difficult to promote its practicality which is mainly subject to their low sensitivity, inferior stability, and reliability. This work reported here an optical fiber surface plasmon resonance (SPR) biosensor enhanced by gold nanoparticles (AuNPs)/Au film coupling for label-free detection the Staphylococcus aureus (S. aureus), while both the gold substrates were successfully biofunctionalized with goat anti-human immunoglobulin G (IgG) as the probe to capture and detect the bacteria. In the experiment, the refractive index（RI） sensitivity of the Multimode-Singlemode-Multimode optical fiber (MSMOF) coated with Au film was improved by 19 % after the AuNPs were homogeneously decorated on the Au film surface. To detect S. aureus by the sensor, the SPR wavelength variation in the transmission spectrum was recorded, and its limit of detection (LOD) was demonstrated experimentally to be about 50 CFU/mL and was obtained theoretically to be 1.18 CFU/mL during its concentration range of 50–108 CFU/mL. Also, it shows great linearity in the range of 102-108 CFU/mL and the sensor exhibits excellent specificity and stability. This kind of SPR-enhanced optical fiber biosensor is fully promising for its applications in biomedicine, food safety, pharmaceuticals, etc.

High sensitivity fiber SPR sensor based on InSe nanosheets and Au nanoparticles

Surface Plasmon Resonance (SPR) fiber sensors are widely used in the field of biosensing. However, there are still issues of low sensitivity and poor stability in practical detection processes. This paper proposes a highly sensitive fiber SPR sensor based on InSe nanosheets and Au nanoparticles. This paper investigates the enhancement effects of different thicknesses of InSe films inserted between the Au film and the fiber and the adsorption of Au nanoparticles on the Au film surface of the fiber-InSe-Au sensor. The sensitivity of the fiber-InSe-Au sensor reaches 5534.76 nm/RIU, which is 2.71 times higher than the fiber-Au sensor and a 22% improvement compared to the fiber-Au-InSe sensor. The sensitivity of the fiber-InSe-Au-AuNPs sensor further increases to 5853.75, and the FOM reaches 28.11, a 47% improvement compared to the fiber-InSe-Au sensor. Moreover, the enhancement substance is situated within the Au film, which enhances the sensor's stability. Additionally, due to the low biotoxicity and high biocompatibility of Au nanoparticles, the high-performance sensor designed in this study is exceptionally well-suited for biosensing applications.