A spectroelectrochemical method based on the enormous intensity enhancement for Raman scattering on an electrode surface is used in order to obtain high resolution vibrational spectra of nucleic acid components in rather dilute aqueous solutions.The laser Raman spectra of adenine, adenosine, and adenosine-5' -monophosphate (5'-AMP) adsorbed at a silver electrode surface have been recorded in the spectral range of loo to 3400 cm−1 . The vibrational bands are sensitive to the adsorption process and exhibit a significantly enhanced intensity.The purine ring-breathing mode at 730 cm−1 shows in all components an enormous enhancement in the intensity of the Raman scattering. A qualitatively similar high Hainan intensity shows the purine skeleton vibration at 1340 cm−1 . In 5'-AMP appears a very intensive band at 248 cm−1 , which is attributed to the Ag-PO32− vibration. The intensity of the Raman scattering will be strongly influenced by these ionic PO32− -group and in AMP a marked enhancement of Raman bands in observed.